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ZANOSAR
Pancreatic, thyroid, and other endocrine cancers
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Drug Name:

ZANOSAR Rx

Generic Name and Formulations:
Streptozocin 1g/vial; pwd for IV inj or infusion after reconstitution/dilution; preservative-free.

Company:
Teva Pharmaceuticals

Therapeutic Use:

Indications for ZANOSAR:

Symptomatic or progressive metastatic pancreatic islet cell cancer.

Adult:

1g/m2 IV once weekly for 2 weeks; may repeat weekly; max 1.5g/m2 per dose. Or, 500mg/m2 IV daily for 5 days every 6 weeks until max benefit or toxicity.

Children:

Not recommended.

Warnings/Precautions:

Renal dysfunction or disease. Monitor renal function (eg, urinalysis, BUN, creatinine, electrolytes) before, weekly during, and for 4 weeks after therapy; discontinue or reduce dose if significant renal toxicity occurs (see literature). Obtain CBCs, liver function tests weekly. Avoid extravasation. Ensure adequate hydration. Elderly. Pregnancy (Cat.D). Nursing mothers: not recommended.

Interactions:

Avoid concomitant nephrotoxic agents. Additive toxicity with other cytotoxic drugs. Severe bone marrow toxicity with doxorubicin. Phenytoin may reduce cytotoxicity.

Pharmacological Class:

Nitrosurea.

Adverse Reactions:

GI upset (may be severe); hematological, hepatic and renal (cumulative and dose-related; may be fatal) toxicity; glucose intolerance, nephrogenic diabetes insipidus, inj site reactions, CNS effects (eg, confusion, lethargy, depression).

How Supplied:

Single-use vial—1

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