Year in Review Schizophrenia

Psychiatric Care for Incarcerated Patients

Psychiatric Care for Incarcerated Patients

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According to one review, there are more individuals with serious mental illness in correctional institutions than in all US state hospitals.

Efficacy of Lurasidone Assessed in Adolescents With Schizophrenia

Efficacy of Lurasidone Assessed in Adolescents With Schizophrenia

Sunovion have announced positive results from a study evaluating Latuda (lurasidone HCI) for the treatment of schizophrenia in adolescents aged 13 to 17 years old.

Prediabetic Markers May Be Linked With First-Episode Psychosis

Prediabetic Markers May Be Linked With First-Episode Psychosis

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The findings might help to explain the increased prevalence of type 2 diabetes in patients with schizophrenia.

Significant Cognitive Impairment in Those At High Risk of Psychosis

Significant Cognitive Impairment in Those At High Risk of Psychosis

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Studying cognition deficits during the clinical high risk period allows researchers to observe cognitive defects before chronicity and long-term medication use obscure the core deficits.

Study Elucidates Role of DIXDC1 Gene in Psychiatric Pathogenesis

Study Elucidates Role of DIXDC1 Gene in Psychiatric Pathogenesis

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Dixdc1 knockout mice demonstrated behaviors suggestive of depression, anxiety, and impaired social behavior.

Gene Expression Patterns in Polygenic Schizophrenia Risk

Gene Expression Patterns in Polygenic Schizophrenia Risk

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Data indicate that 693 genes are differentially expressed between individuals diagnosed with schizophrenia and typical, healthy controls.

Neuroinflammation in Schizophrenia: New PET Brain Imaging Studies

Neuroinflammation in Schizophrenia: New PET Brain Imaging Studies

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TSPO expression is frequently used as a biomarker for brain inflammation during PET imaging.

A Potential Biomarker for the Onset of Psychosis in High-risk Individuals

A Potential Biomarker for the Onset of Psychosis in High-risk Individuals

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Researchers used the auditory mismatch negativity (MMN) paradigm to evaluate its potential as a neurophysiological biomarker for psychosis.

Poorly Organized Fiber Tracts in Patients With Schizophrenia

Poorly Organized Fiber Tracts in Patients With Schizophrenia

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Investigators examined the white matter tracts in patients diagnosed with the schizophrenia with predominantly negative symptoms.

How Reliable Are Patient-reported Outcomes in Schizophrenia?

How Reliable Are Patient-reported Outcomes in Schizophrenia?

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The primary outcome in this study was reliability of patient-ratings on subjective well-being.

Typical Brain Maturation Reveals Clues to Clinical Manifestation of Psychiatric Disorders in Adolescence

Typical Brain Maturation Reveals Clues to Clinical Manifestation of Psychiatric Disorders in Adolescence

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The authors examined measurements of cortical thickness and intracortical magnetization transfer (MT), a validated MRI marker for myelination, over time with regards to genomic patterning.

Can A Risk Calculator Predict Conversion to Psychosis?

Can A Risk Calculator Predict Conversion to Psychosis?

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The researchers referred to their risk calculator as "well-performing."

Cigarette Smoking During Pregnancy Associated With Schizophrenia in Offspring

Cigarette Smoking During Pregnancy Associated With Schizophrenia in Offspring

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Nicotine exposure during pregnancy through cigarette smoking is associated with schizophrenia in offspring.

Immune Activation and Cognitive Impairment in Schizophrenia

Immune Activation and Cognitive Impairment in Schizophrenia

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Study provides further evidence for the effects of inflammation on executive function in patients with schizophrenia.

Assessing Capacity for Decision Making in Schizophrenia: A Case Report

Assessing Capacity for Decision Making in Schizophrenia: A Case Report

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People with psychiatric impairment may be capable of making wise and thoughtful decisions about their lives.

FDA Warning: Antipsychotic Linked to Impulse-Control Problems

FDA Warning: Antipsychotic Linked to Impulse-Control Problems

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The FDA has mandated new warnings to include a list of compulsive behaviors.

Multiple Risk Factors May Predict Treatment-Resistant Schizophrenia

Multiple Risk Factors May Predict Treatment-Resistant Schizophrenia

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Poorly managed treatment-resistant schizophrenia has a significant personal and economic impact, with unfavorable long-term outcomes.

Current Status of Clinical Practice Guidelines in Schizophrenia

Current Status of Clinical Practice Guidelines in Schizophrenia

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The methodological quality of schizophrenia guidelines varies, while lack of consistency across guidelines and inadequate adherence in the clinical setting can impact the quality of care and outcome.

Frequency of Suicidal Ideation Predicts Suicide Attempts But Not Deaths

Frequency of Suicidal Ideation Predicts Suicide Attempts But Not Deaths

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Persistent suicidal ideation was identified in up to 40% of participants with first-episode psychosis.

Taking Psychosis Therapy Into the Digital Age

Taking Psychosis Therapy Into the Digital Age

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SlowMo, a new digital platform for patients to use outside therapy session, targets the psychological processes that play a role in paranoia.

Link Between Adolescent Bullying, Adult Psychosis Not Likely Causal

Link Between Adolescent Bullying, Adult Psychosis Not Likely Causal

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Researchers sought to overcome previous limitations on research exploring childhood bullying and adult psychosis.

Strong Link Found Between Postpartum Depression and Suicide Risk

Strong Link Found Between Postpartum Depression and Suicide Risk

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Study is the first to compare suicide risk of new mothers with postpartum disorder to other categories of women.

Genetic Variant Could Identify Cannabis Users at Risk for Psychosis

Genetic Variant Could Identify Cannabis Users at Risk for Psychosis

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Healthy participants with a variation in the AKT1 gene were at higher risk of acute psychotic response to cannabis.

No Link Between Schizophrenia Risk, Smaller Subcortical Brain Volumes

No Link Between Schizophrenia Risk, Smaller Subcortical Brain Volumes

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Researchers analyzed nearly 12 000 brain scans to investigate whether smaller brain volumes and schizophrenia share any genetic connection.

Subgroups of Schizophrenia Linked to Various Brain Anomalies

Subgroups of Schizophrenia Linked to Various Brain Anomalies

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Different anomalies in the corpus callosum were associated with different symptoms in the schizophrenic participants.

Research Uncovers Genetic Variant Underlying Schizophrenia

Research Uncovers Genetic Variant Underlying Schizophrenia

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In a study of 65 000 participants, researchers uncovered a link between elevated levels of C4A protein, excessive synaptic pruning, and the development of schizophrenia.

Quantitative Measurement in Psychiatry and Personalized Medicine

Quantitative Measurement in Psychiatry and Personalized Medicine

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Therapeutic drug monitoring is vastly underused in psychiatry but could better inform clinical decision-making.

Brain Cell Deficit May Contribute to Schizophrenia

Brain Cell Deficit May Contribute to Schizophrenia

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In a mouse model of schizophrenia, the rodents' brains showed a significant decrease in inhibitory CA2 neurons.

High Fat, Low Carb Diet May Effectively Treat Schizophrenia

High Fat, Low Carb Diet May Effectively Treat Schizophrenia

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The diet provides alternative energy sources from ketone bodies, products of fat breakdown, thereby helping to circumvent abnormally functioning cellular energy pathways in the brain.

Chickens Reveal Genetic Links to Anxiety

Chickens Reveal Genetic Links to Anxiety

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Chicken genes are grouped into much smaller linkage blocks than mammalian genomes are, allowing researchers to pinpoint genome regions associated with a trait, such as anxious behavior.

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