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VALTREX
Viral infections
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Drug Name:

VALTREX Rx

Generic Name and Formulations:
Valacyclovir (as HCl) (prodrug of acyclovir) 500mg, 1g+; caplets; +scored.

Company:
GlaxoSmithKline

Therapeutic Use:

Indications for VALTREX:

Treatment of herpes zoster or herpes labialis. Treatment or suppression of genital herpes in immunocompetent patients. To reduce risk of heterosexual transmission of genital herpes from immunocompetent patients to susceptible partner. Suppression of recurrent genital herpes in HIV-infected patients. Treatment of chickenpox in immunocompetent children.

Adult:

Begin at onset of signs/symptoms (within 48hrs for herpes zoster or initial episode of genital herpes). Coincide a dose for after hemodialysis. ≥18yrs: Herpes zoster: 1g every 8hrs; CrCl 30–49mL/min: 1g every 12hrs; CrCl 10–29mL/min: 1g every 24hrs; CrCl <10mL/min: 500mg every 24hrs; all for 7 days. Initial episode of genital herpes: 1g every 12hrs; CrCl 10–29mL/min: 1g every 24hrs; CrCl <10mL/min: 500mg every 24hrs; all for 10 days. Treatment of recurrent genital herpes: 500mg every 12hrs; CrCl ≤29mL/min: 500mg every 24hrs; both for 3 days. Suppression of recurrent genital herpes if immunocompetent (>9 episodes/yr; reevaluate annually): 1g every 24hrs; CrCl ≤29mL/min: 500mg every 24hrs; (≤9 episodes/yr): 500mg every 24hrs; CrCl ≤29mL/min: 500mg every 48hrs; Reduction of genital herpes transmission risk (≤9 episodes/yr): 500mg every 24hrs for source partner (and use safer sex practices); CrCl ≤29mL/min: 500mg every 48hrs; Suppression of recurrent genital herpes if HIV-infected: 500mg every 12hrs; CrCl ≤29mL/min: 500mg every 24hrs. ≥12yrs: Herpes labialis (treat for 1 day): 2g every 12hrs; CrCl 30–49mL/min: 1g every 12hrs; CrCl 10–29mL/min: 500mg every 12hrs; CrCl <10mL/min: 500mg once.

Children:

Herpes labialis: <12yrs: not recommended. Herpes zoster or genital herpes <18yrs: not recommended. Chickenpox: <2yrs or ≥18yrs: not recommended. Begin at onset of signs/symptoms. 2–18yrs: 20mg/kg three times daily for 5 days; max 1g three times daily. CrCl<50mL/min: not recommended.

Warnings/Precautions:

Renal impairment. Maintain adequate hydration. Elderly. Pregnancy (Cat.B). Nursing mothers.

Interactions:

Renal or CNS toxicity with nephrotoxic drugs.

Pharmacological Class:

Nucleoside analogue.

Adverse Reactions:

Headache, nausea, abdominal pain, dizziness, fatigue, rash, lab abnormalities (CBC, AST, serum creatinine), CNS disturbances (esp. elderly). Thrombotic thrombocytopenic purpura/hemolytic uremic syndrome (in advanced HIV or transplant recipients on 8g/day).

How Supplied:

Caplets—30, 90

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