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VALCHLOR
Leukemias, lymphomas, and other hematologic cancers
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Drug Name:

VALCHLOR Rx

Generic Name and Formulations:
Mechlorethamine 0.016%; topical gel; contains propylene glycol, isopropyl alcohol.

Company:
Actelion Pharmaceuticals

Therapeutic Use:

Indications for VALCHLOR:

Treatment of Stage IA and IB mycosis fungoides-type cutaneous T-cell lymphoma in patients who have received prior skin-directed therapy.

Adult:

Apply a thin film once daily to affected areas of the skin. Apply to completely dry skin ≥4 hours before or 30 minutes after showering or washing. Allow treated areas to completely dry for 5–10 minutes after applying. Wash hands thoroughly after application. Discontinue if any grade of skin ulceration, blistering, or moderately-to-severe, or severe dermatitis occur; restart at reduced frequency of once every 3 days upon improvement; if reintroduction is tolerated for at least 1 week, can increase to every other day for 1 week and then once daily if tolerated.

Children:

Not established.

Warnings/Precautions:

Mucosal (oral, nasal) or eye exposure; blindness and severe irreversible anterior eye injury may occur; immediately irrigate for ≥15 minutes with copious amounts of water. Secondary exposure; avoid direct skin contact with patient. Risk of dermatitis (eg, face, genitalia, anus, and intertriginous skin); monitor for redness, swelling, inflammation, itchiness, blisters, ulceration, and secondary skin infections. Monitor for nonmelanoma skin cancer during and after treatment. Flammable (avoid fire and flame until gel has dried). Pregnancy (Cat.D); may cause fetal harm. Nursing mothers: not recommended.

Pharmacological Class:

Alkylating agent.

Adverse Reactions:

Dermatitis, pruritus, bacterial skin infection, skin ulceration or blistering, hyperpigmentation.

How Supplied:

Gel—60g

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