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UVADEX
Leukemias, lymphomas, and other hematologic cancers
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Drug Name:

UVADEX Rx

Generic Name and Formulations:
Methoxsalen 20mcg/mL; sterile soln.

Company:
Therakos, Inc.

Therapeutic Use:

Indications for UVADEX:

Extracorporeal administration with the UVAR Photopheresis System in the palliative treatment of skin manifestations of cutaneous T-cell lymphoma that is unresponsive to other forms of treatment.

Adult:

Consult UVAR Photopheresis System Operator's Manual before administering. Give on two consecutive days every 4 weeks for minimum of 7 treatment cycles (6 months). 200mcg per photopheresis treatment. Accelerated treatment schedule: see literature.

Children:

Not recommended.

Contraindications:

Idiosyncratic reactions to psoralen compounds. History of light sensitive disease. Lupus erythematosus. Porphyria cutanea tarda. Erythropoietic protoporphyria. Variegate porphyria. Xeroderma pigmentosum. Albinism. Aphakia.

Warnings/Precautions:

Exposure to sun or UV light may cause actinic degeneration, skin burning, cataracts; wear UVA-absorbing, wrap-around sunglasses and cover exposed skin (or use sunblock: SPF ≥15) for 24hrs after treatment. Basal cell carcinomas (monitor and treat if occur). Pregnancy (Cat.D); nursing mothers: not recommended.

Interactions:

Increased photosensitivity with anthralin, coal tar, griseofulvin, phenothiazines, nalidixic acid, halogenated salicylanilides, sulfonamides, tetracyclines, thiazides, organic staining dyes.

Pharmacological Class:

Photoactive agent.

Adverse Reactions:

Hypotension secondary to changes in extracorporeal volume.

How Supplied:

Vials (10mL)—12

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