TEKTURNA HCT Rx
Generic Name and Formulations:
Aliskiren, hydrochlorothiazide; 150mg/12.5mg, 150mg/25mg, 300mg/12.5mg, 300mg/25mg; tabs.
Noden Pharma USA Inc.
Indications for TEKTURNA HCT:
Take consistently with regard to meals. ≥18yrs: 1 tab once daily. Add-on or initial therapy and not volume-depleted: initially 150mg/12.5mg; may increase after 2–4 weeks up to max 300mg/25mg. Replacement therapy: may be substituted for the titrated components. Maximum effect usually seen at 4 weeks.
<18yrs: not established.
Concomitant ARBs or ACEIs in diabetes. Anuria. Sulfonamide allergy.
Fetal toxicity may develop; discontinue if pregnancy is detected. Correct salt/volume depletion before starting therapy or start under close supervision. Discontinue if angioedema or laryngeal edema occurs (have SC epinephrine available). Moderate renal impairment (CrCl <60mL/min): avoid concomitant ARBs or ACEIs. Monitor BP, electrolytes, and renal function periodically. Consider withholding or discontinuing if significant renal dysfunction develops. Renal artery stenosis. Severe HF. Post-MI. Diabetes. Hepatic dysfunction. Asthma. SLE. Gout. Acute myopia. Secondary acute angle-closure glaucoma. Neonates. Pregnancy: avoid. Nursing mothers: not recommended.
Avoid concomitant cyclosporine, itraconazole. Caution with NSAIDs, K+ supplements, K+ sparing diuretics, K+ containing salt substitutes; may cause hyperkalemia. Potentiates antihypertensives, possibly non-depolarizing muscle relaxants. May be antagonized by, and renal toxicity potentiated by NSAIDs (including COX-2 inhibitors): monitor renal function in elderly and/or volume-depleted. Dual inhibition of the renin-angiotensin system with ARBs or ACEIs may increase risk of hypotension, hyperkalemia, renal function changes. Concomitant furosemide; monitor. Adjust antidiabetic drugs. Concomitant lithium (risk of toxicity): monitor. Orthostatic hypotension potentiated by alcohol, CNS depressants. Decreased absorption by cholestyramine, colestipol resins (separate dosing by at least 4hrs), high fat meals.
Direct renin inhibitor + diuretic (thiazide).
Dizziness, flu-like symptoms, diarrhea, cough, vertigo, asthenia, arthralgia, elevated BUN/creatinine, ALT, cholesterol, uric acid; rare: angioedema.
Sign Up for Free e-newsletters
Psychiatry Advisor Articles
- Adjunctive Therapies for Bipolar Disorder Show Promise, Need More Evidence
- Predicting Treatment-Emergent Mania to Tailor Pharmacotherapy in Bipolar Disorder
- Antidepressants Increase Seizure Risk in Youth and Severely Depressed
- Abnormalities of Cortical Thickness in Bipolar Disorder With Auditory Hallucinations
- Prevalence of Major Depressive Disorder Remains High In US Population
- The Way to the Head May Be Through the Gut: Probiotics for Depression
- Suicide-Screening Toolkit Can Help Identify Youths at High Risk for Suicide
- Agoraphobia: An Evolving Understanding of Definitions and Treatment
- Parental Pressure to Diet Linked With Long-term Harm in Adolescents
- Does Access to Medical Cannabis Reduce Risk for Opioid Abuse?
- Suicide Risk After Self-Harm Among Adolescents, Young Adults
- E-Cigarettes Associated With More Harms Than Benefits at Population Level
- Safety, Efficacy of Deep Brain Stimulation for Alzheimer's
- Many Teens Who Use Tobacco Don't Self-Identify as Users
- Evidence of Methylphenidate Abuse: Characterizing Patterns of Use in Pediatric and Adult Populations