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SYNVISC ONE
Arthritis/rheumatic disorders
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Drug Name:

SYNVISC ONE Rx

Generic Name and Formulations:
Hylan G-F 20 (hylan A and hylan B) 48mg; per 6mL; soln for intra-articular inj.

Company:
Sanofi Genzyme Company

Therapeutic Use:

Indications for SYNVISC ONE:

Treatment of pain in osteoarthritis of the knee in patients who have failed to respond adequately to conservative nonpharmacologic therapy and simple analgesics (eg, acetaminophen).

Adult:

Remove synovial fluid or effusion before inj. Give as a single intra-articular inj. 6mL in one knee only.

Children:

Not recommended.

Contraindications:

Knee joint infections. Skin diseases or infections in area of the inj site.

Warnings/Precautions:

Avian protein, feathers, or egg allergy. Severely inflamed knee joints. Lymphatic or venous stasis in leg. Advise patients to avoid strenuous activities for approx. 48 hrs following inj. Pregnancy, nursing mothers: not established.

Interactions:

Avoid use of disinfectants containing quaternary ammonium salts; hyaluronan can precipitate in their presence. Concomitant other intra-articular inj: not studied.

Pharmacological Class:

Hyaluronan derivative.

Adverse Reactions:

Arthralgia, arthritis, arthropathy, inj site pain, gait disturbance; joint effusion, stiffness, swelling, warmth, pain.

Generic Availability:

NO

How Supplied:

Single-use syringe—1

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