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SINGULAIR CHEWABLE
Allergies
Asthma/COPD
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Drug Name:

SINGULAIR CHEWABLE Rx

Generic Name and Formulations:
Montelukast (as sodium) 4mg, 5mg; tabs; cherry flavor; contains phenylalanine.

Company:
Merck & Co., Inc.

Therapeutic Use:

Indications for SINGULAIR CHEWABLE:

Seasonal allergic rhinitis (for patients ≥2yrs old). Perennial allergic rhinitis (for patients ≥6 months old).

Adults and Children:

Take granules by mouth within 15 mins of opening packet; may dissolve in 5mL of cold or room temperature baby formula or breast milk, or mix in spoonful of soft applesauce, carrots, rice, or ice cream. <6 months w/perennial allergic rhinitis or <2yrs w/seasonal allergic rhinitis: not established. 6–23 months: one 4mg granule packet. 2–5yrs: one 4mg chew tab or granule packet. 6–14yrs: one 5mg chew tab. ≥15yrs: one 10mg tab. For all: take once daily.

Warnings/Precautions:

Caution when withdrawing from oral steroids. Avoid abrupt substitution with inhaled or oral steroids. Monitor for neuropsychiatric events; re-evaluate treatment if occurs. Pregnancy (Cat.B). Nursing mothers.

Interactions:

Monitor with potent CYP450 inducers (eg, phenobarbital, rifampin).

See Also:

SINGULAIR

SINGULAIR ORAL GRANULES

Pharmacological Class:

Leukotriene receptor antagonist.

Adverse Reactions:

Upper respiratory infection, fever, headache, pharyngitis, cough, abdominal pain, diarrhea, otitis media, influenza, rhinorrhea, sinusitis; neuropsychiatric events.

Metabolism:

Hepatic (CYP3A4, CYP2C9, CYP2C8). >99% protein bound.

Elimination:

Fecal.

Generic Availability:

YES

How Supplied:

Tabs, chew tabs—30, 90; Oral granules—30

Indications for SINGULAIR CHEWABLE:

Prophylaxis and chronic treatment of asthma (for patients ≥12 months old). Prevention of exercise-induced bronchoconstriction (EIB) (for patients ≥6yrs old).

Adults and Children:

Take granules by mouth within 15 mins of opening packet; may dissolve in 5mL of cold or room temperature baby formula or breast milk, or mix in spoonful of soft applesauce, carrots, rice, or ice cream. <12 months w/asthma or <6yrs w/EIB: not established. 12–23 months: one 4mg granule packet. 2–5yrs: one 4mg chew tab or granule packet. 6–14yrs: one 5mg chew tab. ≥15yrs: 10mg. For asthma: take once daily in the PM. For EIB: Take at least 2hrs before exercise (max 1 dose/day). Do not take an additional dose within 24hrs of a previous dose or if already taking a daily dose for another indication (including chronic asthma).

Warnings/Precautions:

Not for reversal of bronchospasm in acute asthma attacks, including status asthmaticus. Eosinophilic conditions. Caution when withdrawing from oral steroids. Avoid abrupt substitution with inhaled or oral steroids. Monitor for neuropsychiatric events; re-evaluate treatment if occurs. Aspirin sensitivity. Pregnancy (Cat.B). Nursing mothers.

Interactions:

Monitor with potent CYP450 inducers (eg, phenobarbital, rifampin).

See Also:

SINGULAIR

SINGULAIR ORAL GRANULES

Pharmacological Class:

Leukotriene receptor antagonist.

Adverse Reactions:

Upper respiratory infection, fever, headache, pharyngitis, cough, abdominal pain, diarrhea, otitis media, influenza, rhinorrhea, sinusitis; neuropsychiatric events.

Metabolism:

Hepatic (CYP3A4, CYP2C9, CYP2C8). >99% protein bound.

Elimination:

Fecal.

Generic Availability:

YES

How Supplied:

Tabs, chew tabs—30, 90; Oral granules—30

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