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SILVADENE
Skin infections (topicals)
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Drug Name:

SILVADENE Rx

Generic Name and Formulations:
Silver sulfadiazine 1%; cream.

Company:
Pfizer Inc.

Therapeutic Use:

Indications for SILVADENE:

Prophylaxis and treatment of sepsis in 2nd and 3rd degree burns.

Adult:

Apply 1–2 times daily aseptically to approximately 1/16 inch depth to cleansed and debrided burns. Reapply promptly if removed. Continue until wound closed.

Children:

Not established.

Contraindications:

Premature infants. Within first 2 months of birth. Late pregnancy.

Warnings/Precautions:

G6PD deficiency. Impaired renal or hepatic function. Monitor serum sulfa levels and renal function in extensive burns. Avoid eyes. Pregnancy (Cat.B). Nursing mothers: not recommended.

Interactions:

Leukopenia increased with concomitant cimetidine. May inactivate debriding enzymes.

Pharmacological Class:

Sulfonamide antibacterial.

Adverse Reactions:

Transient leukopenia, skin necrosis, erythema multiforme, skin discoloration, burning sensation, rash, pruritus, interstitial nephritis, reduction in bacterial growth; systemic sulfonamide reactions, fungal overgrowth.

How Supplied:

Crm—20g, 50g, 85g, 400g, 1000g

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