An M1-like proinflammatory state is associated with a poor response to antidepressant treatment in bipolar depression with evidence suggesting increased production of cytokines in patients with mood disorders.
Elevated cytokine levels could help to identify children who are unlikely to respond to treatment with fluoxetine.
Researchers found a small number of clinical trials that indicated antidepressant effects of cytokine blockers.
Neuropathic pain has been linked with negative outcomes including psychological distress.
Depression is a major contributor to the overall global burden of disease, with more than 300 million individuals suffering from depression.1 Yet, the limited scope of therapeutics for the condition has left patients with few treatment options and low rates of remission. This may change as progress is made on the pathophysiology of depression. Indeed,…
APA 2016 Coverage
Study provides further evidence for the effects of inflammation on executive function in patients with schizophrenia.
Researchers posit that the influence of gut microbiota extends to the brain via neuroinflammation,
There were significant increases in depression over time in association with greater interpersonal life stressors in girls who had elevated salivary TNF‐α and IL‐1β reactivity to social stress at baseline.
Researchers examined evidence suggesting that probiotics may exert antidepressant effects via anti-inflammatory mechanisms.
Miscellaneous disorders affecting neutrophils and other immune cells or arising in the differential diagnosis of infection What every physician needs to know: Miscellaneous disorders affecting neutrophils and other immune cells or arising in the differential diagnosis of infection: WHIM: warts, hypogammaglobulinemia, infections, and myelokathexis syndrome (CXCR-4 [fusin] mutation – This is a disease associated with…