Schizophrenia

No Difference Between Omega-3 & Placebo in Patients at Ultrahigh Risk for Psychosis

No Difference Between Omega-3 & Placebo in Patients at Ultrahigh Risk for Psychosis

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PUFA supplementation offers little additional aid to psychosis when good psychosocial care is already sought.

Gene Expression Patterns in Polygenic Schizophrenia Risk

Gene Expression Patterns in Polygenic Schizophrenia Risk

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Data indicate that 693 genes are differentially expressed between individuals diagnosed with schizophrenia and typical, healthy controls.

Ambiguity Aversion is Attenuated in Schizophrenia

Ambiguity Aversion is Attenuated in Schizophrenia

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Researchers conducted an fMRI study of decision-making under conditions of risk and ambiguity in patients diagnosed with schizophrenia.

Low Levels of Vitamin D in Patients With Bipolar Disorder

Low Levels of Vitamin D in Patients With Bipolar Disorder

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Approximately 2.5% of people worldwide are estimated to have bipolar spectrum disorders, which are a significant cause of neuropsychiatric disability.

Haloperidol in the Emergency Department Setting

Haloperidol in the Emergency Department Setting

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Dr. Scott Zeller suggests it is time to move away from emergency intramuscular haloperidol.

Effort Allocation Influences Upon Cognition in Schizophrenia

Effort Allocation Influences Upon Cognition in Schizophrenia

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Researchers studied social cognition and social problem solving in patients with schizophrenia by employing a validated test designed to assess emotion recognition abilities.

Delusions in Schizophrenia Associated With Myelin Abnormalities, Neuroinflammation

Delusions in Schizophrenia Associated With Myelin Abnormalities, Neuroinflammation

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Study provides further evidence for the effects of white matter fiber abnormalities and neuroinflammation on positive symptoms in patients with schizophrenia.

Gene Sets Altered Across Brain Regions in Schizophrenia, Bipolar Disorder & MDD

Gene Sets Altered Across Brain Regions in Schizophrenia, Bipolar Disorder & MDD

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Until now, the majority of postmortem research that has examined functionally related gene sets has been limited to a single disorder or region of the brain.

Bipolar and Schizophrenia Disorders Accurately Predicted With WERCAP Sections

Bipolar and Schizophrenia Disorders Accurately Predicted With WERCAP Sections

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By using the Washington Early Recognition Center Affectivity and Psychosis (WERCAP) questionnaire, investigators accurately predicted bipolar disorder or schizophrenia in more than 85% of patients.

White Matter Abnormalities and Clinical Symptom Severity in Schizophrenia

White Matter Abnormalities and Clinical Symptom Severity in Schizophrenia

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New findings provide an insight about the association between white matter microstructure and the severity of schizophrenia clinical symptoms.

Interaction of Proline and COMT Genotype Influences Negative Symptoms in Schizophrenia & Bipolar Disorder

Interaction of Proline and COMT Genotype Influences Negative Symptoms in Schizophrenia & Bipolar Disorder

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The authors explored whether valproate (VPA) treatment effects vary by catechol-O-methyltransferase (COMT) genotype.

Neuroimaging of Schizophrenia: The Importance of Illness Severity and Duration

Neuroimaging of Schizophrenia: The Importance of Illness Severity and Duration

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Researchers used voxel-based morphometry, which allows examination on a voxel-wise basis across the whole brain, to assess whether structural abnormalities in schizophrenia are static or progressive.

mPFC Abnormalities Associated With Social Cognition Deficits in Schizophrenia

mPFC Abnormalities Associated With Social Cognition Deficits in Schizophrenia

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Poor psychosocial functioning among individuals diagnosed with schizophrenia is associated with deficits in social cognition.

Neuroinflammation in Schizophrenia: New PET Brain Imaging Studies

Neuroinflammation in Schizophrenia: New PET Brain Imaging Studies

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TSPO expression is frequently used as a biomarker for brain inflammation during PET imaging.

Clinical, But Not Subclinical, Psychosis Linked with Less Physical Activity

Clinical, But Not Subclinical, Psychosis Linked with Less Physical Activity

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Low physical activity was defined as less than 150 minutes of moderate-to-vigorous exercise per week.

A Potential Biomarker for the Onset of Psychosis in High-risk Individuals

A Potential Biomarker for the Onset of Psychosis in High-risk Individuals

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Researchers used the auditory mismatch negativity (MMN) paradigm to evaluate its potential as a neurophysiological biomarker for psychosis.

Poorly Organized Fiber Tracts in Patients With Schizophrenia

Poorly Organized Fiber Tracts in Patients With Schizophrenia

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Investigators examined the white matter tracts in patients diagnosed with the schizophrenia with predominantly negative symptoms.

Cannabinoid Receptor System Dysregulation in Schizophrenia

Cannabinoid Receptor System Dysregulation in Schizophrenia

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Researchers explored the role of the dysregulated cannabinoid receptor system in patients diagnosed with schizophrenia.

How Reliable Are Patient-reported Outcomes in Schizophrenia?

How Reliable Are Patient-reported Outcomes in Schizophrenia?

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The primary outcome in this study was reliability of patient-ratings on subjective well-being.

Personalized Treatment With Second vs. First Generation Antipsychotics

Personalized Treatment With Second vs. First Generation Antipsychotics

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The primary outcome in this study was the change in total quality-of-life scores from baseline to week 24 after patients were randomly assigned to a treatment group.

Cognition and White Matter Alterations in Schizophrenia, Bipolar Disorder

Cognition and White Matter Alterations in Schizophrenia, Bipolar Disorder

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Direct comparison of white matter tracts between individuals with schizophrenia or bipolar disorder has not been performed to date.

Psychosocial and Demographic Predictors of Depression Among Individuals With Bipolar Disorder and Schizophrenia

Psychosocial and Demographic Predictors of Depression Among Individuals With Bipolar Disorder and Schizophrenia

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Bipolar disorder and schizophrenia are characterized by significant genetic overlap, as well as significant clinical presentation overlap.

Typical Brain Maturation Reveals Clues to Clinical Manifestation of Psychiatric Disorders in Adolescence

Typical Brain Maturation Reveals Clues to Clinical Manifestation of Psychiatric Disorders in Adolescence

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The authors examined measurements of cortical thickness and intracortical magnetization transfer (MT), a validated MRI marker for myelination, over time with regards to genomic patterning.

Polygenic Schizophrenia Risk Score Linked with Hippocampal Volume and Psychosis Status

Polygenic Schizophrenia Risk Score Linked with Hippocampal Volume and Psychosis Status

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Previous studies comparing the hippocampal volume of at-risk mental state (ARMS) and first-episode psychosis (FEP) patients have produced mixed findings.

Cortical Molecular Markers Differentiate Psychotic, Bipolar Disorders

Cortical Molecular Markers Differentiate Psychotic, Bipolar Disorders

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The researchers quantified the transcript levels of GAD67, parvalbumin, somastatin, and Lhx6 in the prefrontal cortex.

Can A Risk Calculator Predict Conversion to Psychosis?

Can A Risk Calculator Predict Conversion to Psychosis?

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The researchers referred to their risk calculator as "well-performing."

Novel Candidate Biomarker Identified for Schizophrenia

Novel Candidate Biomarker Identified for Schizophrenia

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Whereas the expression levels of CDK4 and MCM7 were significantly decreased only in the acute state, POLD4 was significantly decreased in the acute and remission states in the patients diagnosed with schizophrenia.

Longer Untreated Psychosis in Youth Associated With Worse Outcomes

Longer Untreated Psychosis in Youth Associated With Worse Outcomes

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So far, the clinical presentation of psychosis in childhood and adolescence has only been examined in a small number of studies which are limited by small sample sizes.

Study Links Acute Mania With Antibiotic Usage

Study Links Acute Mania With Antibiotic Usage

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Investigators examined antibiotic use in patients with bipolar disorder, schizophrenia, and major depressive disorder.

Common Meds Increase Hospitalization for Dehydration, Heat-Linked Illness

Common Meds Increase Hospitalization for Dehydration, Heat-Linked Illness

Commonly used medications have been linked to an increased risk of hospitalization for dehydration and heat-related illness.

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