Young patients with first-episode psychosis may be able to achieve recovery.
Benefits of NMDA receptor agonists in patients with schizophrenia include improvements with memory and reading.
PUFA supplementation offers little additional aid to psychosis when good psychosocial care is already sought.
Data indicate that 693 genes are differentially expressed between individuals diagnosed with schizophrenia and typical, healthy controls.
Researchers conducted an fMRI study of decision-making under conditions of risk and ambiguity in patients diagnosed with schizophrenia.
Approximately 2.5% of people worldwide are estimated to have bipolar spectrum disorders, which are a significant cause of neuropsychiatric disability.
Dr. Scott Zeller suggests it is time to move away from emergency intramuscular haloperidol.
Researchers studied social cognition and social problem solving in patients with schizophrenia by employing a validated test designed to assess emotion recognition abilities.
Study provides further evidence for the effects of white matter fiber abnormalities and neuroinflammation on positive symptoms in patients with schizophrenia.
Until now, the majority of postmortem research that has examined functionally related gene sets has been limited to a single disorder or region of the brain.
By using the Washington Early Recognition Center Affectivity and Psychosis (WERCAP) questionnaire, investigators accurately predicted bipolar disorder or schizophrenia in more than 85% of patients.
New findings provide an insight about the association between white matter microstructure and the severity of schizophrenia clinical symptoms.
Interaction of Proline and COMT Genotype Influences Negative Symptoms in Schizophrenia & Bipolar DisorderSeptember 27, 2016
The authors explored whether valproate (VPA) treatment effects vary by catechol-O-methyltransferase (COMT) genotype.
Researchers used voxel-based morphometry, which allows examination on a voxel-wise basis across the whole brain, to assess whether structural abnormalities in schizophrenia are static or progressive.
Poor psychosocial functioning among individuals diagnosed with schizophrenia is associated with deficits in social cognition.
TSPO expression is frequently used as a biomarker for brain inflammation during PET imaging.
Low physical activity was defined as less than 150 minutes of moderate-to-vigorous exercise per week.
Researchers used the auditory mismatch negativity (MMN) paradigm to evaluate its potential as a neurophysiological biomarker for psychosis.
Investigators examined the white matter tracts in patients diagnosed with the schizophrenia with predominantly negative symptoms.
Researchers explored the role of the dysregulated cannabinoid receptor system in patients diagnosed with schizophrenia.
The primary outcome in this study was reliability of patient-ratings on subjective well-being.
The primary outcome in this study was the change in total quality-of-life scores from baseline to week 24 after patients were randomly assigned to a treatment group.
Direct comparison of white matter tracts between individuals with schizophrenia or bipolar disorder has not been performed to date.
Psychosocial and Demographic Predictors of Depression Among Individuals With Bipolar Disorder and SchizophreniaAugust 15, 2016
Bipolar disorder and schizophrenia are characterized by significant genetic overlap, as well as significant clinical presentation overlap.
Typical Brain Maturation Reveals Clues to Clinical Manifestation of Psychiatric Disorders in AdolescenceAugust 13, 2016
The authors examined measurements of cortical thickness and intracortical magnetization transfer (MT), a validated MRI marker for myelination, over time with regards to genomic patterning.
Previous studies comparing the hippocampal volume of at-risk mental state (ARMS) and first-episode psychosis (FEP) patients have produced mixed findings.
The researchers quantified the transcript levels of GAD67, parvalbumin, somastatin, and Lhx6 in the prefrontal cortex.
The researchers referred to their risk calculator as "well-performing."
Whereas the expression levels of CDK4 and MCM7 were significantly decreased only in the acute state, POLD4 was significantly decreased in the acute and remission states in the patients diagnosed with schizophrenia.
So far, the clinical presentation of psychosis in childhood and adolescence has only been examined in a small number of studies which are limited by small sample sizes.
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