Common Meds Increase Hospitalization for Dehydration, Heat-Linked Illness

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Commonly used medications have been linked to an increased risk of hospitalization for dehydration and heat-related illness.
Commonly used medications have been linked to an increased risk of hospitalization for dehydration and heat-related illness.

HealthDay News — Among veterans, initiation of many commonly-used medications is associated with increased risk of hospitalization for dehydration or heat-related illness, according to research published online July 4 in the Journal of Clinical Pharmacy and Therapeutics.

Lisa M. Kalisch Ellett, PhD, from the University of South Australia in Adelaide, and colleagues conducted a retrospective analysis using prescription event symmetry analysis for 6700 veterans with incident hospital admission for dehydration or heat-related illness.

 

The researchers found that the risk of incident hospital admission for dehydration or heat-related illness was significantly increased following initiation of anticoagulants, cardiovascular medicines, nonsteroidal anti-inflammatory drugs, antipsychotics, antidepressants, and anticholinergic agents. There was variation in the risk of hospital admission for dehydration or heat-related illness from 1.17 for selective serotonin reuptake inhibitor to 2.79 for angiotensin converting enzyme inhibitor plus diuretic combination product. Initiation of anticonvulsants, anti-Parkinson's agents, hypnotics, anxiolytics, or antihistamines was not significantly associated with hospital admission for dehydration or heat-related illness.

"Many commonly used medicines were found to be associated with increased risk of hospitalization for dehydration or heat-related illness," the authors wrote. "Prescribers and patients should be aware of the potential for medicines to be associated with increased risk of dehydration and heat-related illness."

Reference

Kalisch Ellett LM, Pratt NL, Le Blank VT, Westaway K, Roughead EE. Increased risk of hospital admission for dehydration or heat-related illness after initiation of medicines: a sequence symmetry analysis. J Clin Pharm Ther. 2016; doi:10.1111/jcpt.12418.

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