Schizophrenia & Psychoses

Plasma Autoantibodies Possible Biomarker for Schizophrenia

Plasma Autoantibodies Possible Biomarker for Schizophrenia

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Investigators selected 15 genes associated with schizophrenia due to high expression in both brain tissue and B-lymphocyte cells.

Virtual Reality Can Reduce Anxiety, Improve Social Interactions in Psychosis

Virtual Reality Can Reduce Anxiety, Improve Social Interactions in Psychosis

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Use of virtual reality environments in which participants interact with computer-controlled situations or avatars enables a more fine-tuned approach to exposure in the context of cognitive behavioral therapy.

Transcranial Direct Current Stimulation May Improve Motor Learning in Nonclinical Psychosis

Transcranial Direct Current Stimulation May Improve Motor Learning in Nonclinical Psychosis

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tDCS may be an important tool for further improving our understanding of psychosis and designing targeted treatments.

First-Episode Schizophrenia: Searching for the Most Effective Atypical Antipsychotic

First-Episode Schizophrenia: Searching for the Most Effective Atypical Antipsychotic

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Researchers examined which atypical antipsychotic was more effective and safe in first-episode drug-naive schizophrenia.

Atypical Antipsychotic Pharmacokinetics

A chart outlining the pharmacokinetics of atypical antipsychotics, including information on bioavailability, half-life and CYP 450 metabolism.

Examining the Benefit of Benzodiazepines for Psychosis-Associated Aggression, Agitation

Examining the Benefit of Benzodiazepines for Psychosis-Associated Aggression, Agitation

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A meta-analysis of randomized, controlled trials compared the use of benzodiazepines alone or in combination with antipsychotic or antihistamine medications in patients experiencing acute psychotic illness.

Psychosis Associated With Increased Complications Following Total Joint Arthroplasty

Psychosis Associated With Increased Complications Following Total Joint Arthroplasty

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Investigators seek the association between psychosis and complication risk after total joint arthroplasty.

Suppression of Auditory Stimuli Associated With Pathologic Symptoms of Schizophrenia

Suppression of Auditory Stimuli Associated With Pathologic Symptoms of Schizophrenia

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P50 processing may inform researchers in the future development of interventions targeting cognitive impairment in schizophrenia.

Daily Dose Thresholds: Antipsychotics

A chart with daily dose thresholds for antipsychotic medications.

Advanced Paternal Age Associated With Development of Schizophrenia, Mental Disorders

Advanced Paternal Age Associated With Development of Schizophrenia, Mental Disorders

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Investigators seek the association between the risk of developing schizophrenia and advanced maternal and paternal age.

Subtle Gender Differences in Self-Perceived Symptoms of First-Episode Psychosis

Subtle Gender Differences in Self-Perceived Symptoms of First-Episode Psychosis

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Gender differences may predict the types of symptoms and age of onset of schizophrenic psychosis.

Cardiovascular, Metabolic Biomarker Assessment in Early Psychosis

Cardiovascular, Metabolic Biomarker Assessment in Early Psychosis

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Investigators assessed biomarkers for cardiovascular risk and protection in individuals with first-episode psychosis.

Effects of Social Recovery Therapy on Functional Outcomes in First-Episode Psychosis

Effects of Social Recovery Therapy on Functional Outcomes in First-Episode Psychosis

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Investigators believe social recovery therapy may benefit individuals with complex comorbidities not motivated to participate in psychosocial interventions targeting functioning after first-episode psychosis.

Examining the Potential of Neuroanatomical Imaging Signature for Schizophrenia Biomarkers

Examining the Potential of Neuroanatomical Imaging Signature for Schizophrenia Biomarkers

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Technique validation suggested a robust generalizability of neuroanatomical imaging in schizophrenia.

FDA Approves Schizophrenia Medication With Digital Ingestion Sensor

FDA Approves Schizophrenia Medication With Digital Ingestion Sensor

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The ability to track ingestion of medications prescribed for mental illness may be useful for some patients.

Diabetes Risk for Children, Young Adults on Second-Generation Antipsychotics

Diabetes Risk for Children, Young Adults on Second-Generation Antipsychotics

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Type 2 diabetes is greater with second-generation antipsychotics than with non-second-generation antipsychotic psychotropic medications for patients aged 6 to 25 years.

FDA Issues Refusal to File Letter in Response to New Schizophrenia Drug

FDA Issues Refusal to File Letter in Response to New Schizophrenia Drug

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The FDA issued a refusal to file letter for a new drug application.

Guidance for Managing Treatment-Resistant Schizophrenia

Guidance for Managing Treatment-Resistant Schizophrenia

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Different clinical and neurobiologic pathways may be involved in treatment-resistant schizophrenia as it is not a homogeneous subgroup within the schizophrenia spectrum.

Why Do Antipsychotics Cause Weight Gain?

Why Do Antipsychotics Cause Weight Gain?

Researchers from the University of Texas Southwestern Medical Center have discovered the cellular receptor that causes weight gain from antipsychotic drugs.

Shared Decision Making in Psychiatry:  An Effective Practice Strategy

Shared Decision Making in Psychiatry: An Effective Practice Strategy

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Shared decision making encourages a clinical partnership that can result in optimal treatment outcomes.

Psychosis Relapse Risk With Continued Cannabis Use and Poor Medication Adherence

Psychosis Relapse Risk With Continued Cannabis Use and Poor Medication Adherence

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Interventions targeted at improving medication adherence might mitigate adverse effects of cannabis use on psychosis outcomes.

Long-Acting Injectable Antipsychotic May Reduce Costs, Increase Adherence in Schizophrenia

Long-Acting Injectable Antipsychotic May Reduce Costs, Increase Adherence in Schizophrenia

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Long-acting injectables should be considered earlier in the treatment of schizophrenia.

Increases in Autonomic Function May Predict Auditory Hallucinations in SCZ

Increases in Autonomic Function May Predict Auditory Hallucinations in SCZ

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Increases in autonomic function may predict the occurrence and severity of auditory hallucinations in patients with schizophrenia, suggesting a regulation of these experiences by the autonomic nervous system.

Diabetes Mellitus More Prevalent In Psychiatric Patients Than General Population

Diabetes Mellitus More Prevalent In Psychiatric Patients Than General Population

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Diabetes mellitus (DM) appears to be more prevalent in the psychiatric setting than in the general population.

Schizophrenia Relapse Rate Lower With Injectable Versus Oral Antipsychotics

Schizophrenia Relapse Rate Lower With Injectable Versus Oral Antipsychotics

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The risk for rehospitalization was 22% lower during treatment with long-acting injectable antipsychotic medications compared with treatment with equivalent oral formulations in the total cohort.

Schizophrenia Symptoms May Benefit From Specific Kind of Talk Therapy

Schizophrenia Symptoms May Benefit From Specific Kind of Talk Therapy

Schizophrenia patients may benefit from a a specific type of talk therapy, according to a new study from the University of Pennsylvania.

Concomitant Use of Antidepressants, Antipsychotics Linked to T2D Risk

Concomitant Use of Antidepressants, Antipsychotics Linked to T2D Risk

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Concomitant SSRI/SNRI use was associated with an increased diabetes risk in AAP-treated young people.

Schizophrenia: Are There Any Effective Pharmacologic Combinations?

Schizophrenia: Are There Any Effective Pharmacologic Combinations?

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There is currently no approved drug combination for treatment-resistant schizophrenia.

Cardiometabolic Outcomes in Schizophrenia Improved by Liraglutide

Cardiometabolic Outcomes in Schizophrenia Improved by Liraglutide

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In patients with schizophrenia being treated with clozapine or olanzapine, liraglutide significantly improved glucose tolerance, body weight, and other cardiometabolic disturbances.

Schizophrenia Treatment Can Benefit From Electroconvulsive Therapy

Schizophrenia Treatment Can Benefit From Electroconvulsive Therapy

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Electroconvulsive therapy can be a clinically effective treatment for patients with severe forms of schizophrenia.

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