Schizophrenia & Psychoses
According to one review, there are more individuals with serious mental illness in correctional institutions than in all US state hospitals.
Sunovion have announced positive results from a study evaluating Latuda (lurasidone HCI) for the treatment of schizophrenia in adolescents aged 13 to 17 years old.
40-Hz ASSR spectral power and phase-locking deficits could be useful probes for assessing circuit dysfunctions in the disorder.
The findings might help to explain the increased prevalence of type 2 diabetes in patients with schizophrenia.
Studying cognition deficits during the clinical high risk period allows researchers to observe cognitive defects before chronicity and long-term medication use obscure the core deficits.
Dixdc1 knockout mice demonstrated behaviors suggestive of depression, anxiety, and impaired social behavior.
Medications used to treat addiction cut the risk of reoffending in half.
Indicators of schizophrenia, obsessive-compulsive disorder, and anxiety might be spotted in physical symptoms at age 18.
The Effect of Cognitive Remediation Training on Functional Connectivity and Social Cognition in SchizophreniaOctober 13, 2016
Study provides further evidence for the effects of cognitive enhancement intervention on brain functional connectivity and cognitive performance in patients with schizophrenia.
Data indicate that 693 genes are differentially expressed between individuals diagnosed with schizophrenia and typical, healthy controls.
Dr. Scott Zeller suggests it is time to move away from emergency intramuscular haloperidol.
Researchers studied social cognition and social problem solving in patients with schizophrenia by employing a validated test designed to assess emotion recognition abilities.
Study provides further evidence for the effects of white matter fiber abnormalities and neuroinflammation on positive symptoms in patients with schizophrenia.
New findings provide an insight about the association between white matter microstructure and the severity of schizophrenia clinical symptoms.
Interaction of Proline and COMT Genotype Influences Negative Symptoms in Schizophrenia & Bipolar DisorderSeptember 27, 2016
The authors explored whether valproate (VPA) treatment effects vary by catechol-O-methyltransferase (COMT) genotype.
Poor psychosocial functioning among individuals diagnosed with schizophrenia is associated with deficits in social cognition.
TSPO expression is frequently used as a biomarker for brain inflammation during PET imaging.
Low physical activity was defined as less than 150 minutes of moderate-to-vigorous exercise per week.
Researchers used the auditory mismatch negativity (MMN) paradigm to evaluate its potential as a neurophysiological biomarker for psychosis.
Investigators examined the white matter tracts in patients diagnosed with the schizophrenia with predominantly negative symptoms.
The primary outcome in this study was reliability of patient-ratings on subjective well-being.
The primary outcome in this study was the change in total quality-of-life scores from baseline to week 24 after patients were randomly assigned to a treatment group.
Direct comparison of white matter tracts between individuals with schizophrenia or bipolar disorder has not been performed to date.
Psychosocial and Demographic Predictors of Depression Among Individuals With Bipolar Disorder and SchizophreniaAugust 15, 2016
Bipolar disorder and schizophrenia are characterized by significant genetic overlap, as well as significant clinical presentation overlap.
Typical Brain Maturation Reveals Clues to Clinical Manifestation of Psychiatric Disorders in AdolescenceAugust 13, 2016
The authors examined measurements of cortical thickness and intracortical magnetization transfer (MT), a validated MRI marker for myelination, over time with regards to genomic patterning.
Previous studies comparing the hippocampal volume of at-risk mental state (ARMS) and first-episode psychosis (FEP) patients have produced mixed findings.
The researchers quantified the transcript levels of GAD67, parvalbumin, somastatin, and Lhx6 in the prefrontal cortex.
The researchers referred to their risk calculator as "well-performing."
So far, the clinical presentation of psychosis in childhood and adolescence has only been examined in a small number of studies which are limited by small sample sizes.
Genetic risk for psychosis influences reward processing in healthy adolescents.
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