Schizophrenia & Psychoses

Psychiatric Care for Incarcerated Patients

Psychiatric Care for Incarcerated Patients

By

According to one review, there are more individuals with serious mental illness in correctional institutions than in all US state hospitals.

Efficacy of Lurasidone Assessed in Adolescents With Schizophrenia

Efficacy of Lurasidone Assessed in Adolescents With Schizophrenia

Sunovion have announced positive results from a study evaluating Latuda (lurasidone HCI) for the treatment of schizophrenia in adolescents aged 13 to 17 years old.

Impaired Auditory 40-Hz Steady-State Responses Noted in Schizophrenia

Impaired Auditory 40-Hz Steady-State Responses Noted in Schizophrenia

By

40-Hz ASSR spectral power and phase-locking deficits could be useful probes for assessing circuit dysfunctions in the disorder.

Prediabetic Markers May Be Linked With First-Episode Psychosis

Prediabetic Markers May Be Linked With First-Episode Psychosis

By

The findings might help to explain the increased prevalence of type 2 diabetes in patients with schizophrenia.

Significant Cognitive Impairment in Those At High Risk of Psychosis

Significant Cognitive Impairment in Those At High Risk of Psychosis

By

Studying cognition deficits during the clinical high risk period allows researchers to observe cognitive defects before chronicity and long-term medication use obscure the core deficits.

Study Elucidates Role of DIXDC1 Gene in Psychiatric Pathogenesis

Study Elucidates Role of DIXDC1 Gene in Psychiatric Pathogenesis

By

Dixdc1 knockout mice demonstrated behaviors suggestive of depression, anxiety, and impaired social behavior.

Psych Meds Rx May Reduce Violent Reoffending in Ex-Prisoners

Psych Meds Rx May Reduce Violent Reoffending in Ex-Prisoners

Medications used to treat addiction cut the risk of reoffending in half.

Heart Rate, BP in Male Teens Linked to Risk for Psych Disorders

Heart Rate, BP in Male Teens Linked to Risk for Psych Disorders

Indicators of schizophrenia, obsessive-compulsive disorder, and anxiety might be spotted in physical symptoms at age 18.

The Effect of Cognitive Remediation Training on Functional Connectivity and Social Cognition in Schizophrenia

The Effect of Cognitive Remediation Training on Functional Connectivity and Social Cognition in Schizophrenia

By

Study provides further evidence for the effects of cognitive enhancement intervention on brain functional connectivity and cognitive performance in patients with schizophrenia.

Gene Expression Patterns in Polygenic Schizophrenia Risk

Gene Expression Patterns in Polygenic Schizophrenia Risk

By

Data indicate that 693 genes are differentially expressed between individuals diagnosed with schizophrenia and typical, healthy controls.

Haloperidol in the Emergency Department Setting

Haloperidol in the Emergency Department Setting

By

Dr. Scott Zeller suggests it is time to move away from emergency intramuscular haloperidol.

Effort Allocation Influences Upon Cognition in Schizophrenia

Effort Allocation Influences Upon Cognition in Schizophrenia

By

Researchers studied social cognition and social problem solving in patients with schizophrenia by employing a validated test designed to assess emotion recognition abilities.

Delusions in Schizophrenia Associated With Myelin Abnormalities, Neuroinflammation

Delusions in Schizophrenia Associated With Myelin Abnormalities, Neuroinflammation

By

Study provides further evidence for the effects of white matter fiber abnormalities and neuroinflammation on positive symptoms in patients with schizophrenia.

White Matter Abnormalities and Clinical Symptom Severity in Schizophrenia

White Matter Abnormalities and Clinical Symptom Severity in Schizophrenia

By

New findings provide an insight about the association between white matter microstructure and the severity of schizophrenia clinical symptoms.

Interaction of Proline and COMT Genotype Influences Negative Symptoms in Schizophrenia & Bipolar Disorder

Interaction of Proline and COMT Genotype Influences Negative Symptoms in Schizophrenia & Bipolar Disorder

By

The authors explored whether valproate (VPA) treatment effects vary by catechol-O-methyltransferase (COMT) genotype.

mPFC Abnormalities Associated With Social Cognition Deficits in Schizophrenia

mPFC Abnormalities Associated With Social Cognition Deficits in Schizophrenia

By

Poor psychosocial functioning among individuals diagnosed with schizophrenia is associated with deficits in social cognition.

Neuroinflammation in Schizophrenia: New PET Brain Imaging Studies

Neuroinflammation in Schizophrenia: New PET Brain Imaging Studies

By

TSPO expression is frequently used as a biomarker for brain inflammation during PET imaging.

Clinical, But Not Subclinical, Psychosis Linked with Less Physical Activity

Clinical, But Not Subclinical, Psychosis Linked with Less Physical Activity

By

Low physical activity was defined as less than 150 minutes of moderate-to-vigorous exercise per week.

A Potential Biomarker for the Onset of Psychosis in High-risk Individuals

A Potential Biomarker for the Onset of Psychosis in High-risk Individuals

By

Researchers used the auditory mismatch negativity (MMN) paradigm to evaluate its potential as a neurophysiological biomarker for psychosis.

Poorly Organized Fiber Tracts in Patients With Schizophrenia

Poorly Organized Fiber Tracts in Patients With Schizophrenia

By

Investigators examined the white matter tracts in patients diagnosed with the schizophrenia with predominantly negative symptoms.

How Reliable Are Patient-reported Outcomes in Schizophrenia?

How Reliable Are Patient-reported Outcomes in Schizophrenia?

By

The primary outcome in this study was reliability of patient-ratings on subjective well-being.

Personalized Treatment With Second vs. First Generation Antipsychotics

Personalized Treatment With Second vs. First Generation Antipsychotics

By

The primary outcome in this study was the change in total quality-of-life scores from baseline to week 24 after patients were randomly assigned to a treatment group.

Cognition and White Matter Alterations in Schizophrenia, Bipolar Disorder

Cognition and White Matter Alterations in Schizophrenia, Bipolar Disorder

By

Direct comparison of white matter tracts between individuals with schizophrenia or bipolar disorder has not been performed to date.

Psychosocial and Demographic Predictors of Depression Among Individuals With Bipolar Disorder and Schizophrenia

Psychosocial and Demographic Predictors of Depression Among Individuals With Bipolar Disorder and Schizophrenia

By

Bipolar disorder and schizophrenia are characterized by significant genetic overlap, as well as significant clinical presentation overlap.

Typical Brain Maturation Reveals Clues to Clinical Manifestation of Psychiatric Disorders in Adolescence

Typical Brain Maturation Reveals Clues to Clinical Manifestation of Psychiatric Disorders in Adolescence

By

The authors examined measurements of cortical thickness and intracortical magnetization transfer (MT), a validated MRI marker for myelination, over time with regards to genomic patterning.

Polygenic Schizophrenia Risk Score Linked with Hippocampal Volume and Psychosis Status

Polygenic Schizophrenia Risk Score Linked with Hippocampal Volume and Psychosis Status

By

Previous studies comparing the hippocampal volume of at-risk mental state (ARMS) and first-episode psychosis (FEP) patients have produced mixed findings.

Cortical Molecular Markers Differentiate Psychotic, Bipolar Disorders

Cortical Molecular Markers Differentiate Psychotic, Bipolar Disorders

By

The researchers quantified the transcript levels of GAD67, parvalbumin, somastatin, and Lhx6 in the prefrontal cortex.

Can A Risk Calculator Predict Conversion to Psychosis?

Can A Risk Calculator Predict Conversion to Psychosis?

By

The researchers referred to their risk calculator as "well-performing."

Longer Untreated Psychosis in Youth Associated With Worse Outcomes

Longer Untreated Psychosis in Youth Associated With Worse Outcomes

By

So far, the clinical presentation of psychosis in childhood and adolescence has only been examined in a small number of studies which are limited by small sample sizes.

Aberrant Reward Processing Likely Precedes Psychotic Disorders

Aberrant Reward Processing Likely Precedes Psychotic Disorders

By

Genetic risk for psychosis influences reward processing in healthy adolescents.

Sign Up for Free e-newsletters