Schizophrenia & Psychoses

Psychosis Treatments

A comparative dosing and titration chart of commonly used first-generation and second-generation antipsychotics.

HIV Viral Suppression Rates in Psychiatric Inpatients With Comorbid Substance Use Disorders

HIV Viral Suppression Rates in Psychiatric Inpatients With Comorbid Substance Use Disorders

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A substantial proportion of these individuals diagnosed with HIV, psychiatric disorders, and substance use disorders are out of care and urgently require intervention.

Early Intervention Services Superior to Treatment as Usual for Early-Phase Psychosis

Early Intervention Services Superior to Treatment as Usual for Early-Phase Psychosis

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The superior benefit provided by early intervention services for schizophrenia could be cost-effective, and the researchers call for widespread implementation and funding of early intervention services in the United States and globally.

Gyrification-Based Connectomes Appear Promising for Predicting Transition to Psychosis

Gyrification-Based Connectomes Appear Promising for Predicting Transition to Psychosis

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To date, there has been limited prognostic accuracy of clinical instruments in predicting the onset of psychosis and no reliable biological marker has been identified.

Substance Use Disorders Associated With Conversion From Schizotypal Disorder to Schizophrenia

Substance Use Disorders Associated With Conversion From Schizotypal Disorder to Schizophrenia

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These data may be helpful in titrating care for those with schizotypal disorder and comorbid substance abuse disorders to mitigate the risk for conversion to schizophrenia.

Haloperidol Associated With Slight Increased Risk for Death in Acute Myocardial Infarction

Haloperidol Associated With Slight Increased Risk for Death in Acute Myocardial Infarction

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These data may be useful to clinicians in considering the risks and benefits of prescribing haloperidol for patients with cardiac morbidity.

Exploring Brain Stimulation as a Treatment for Auditory Hallucinations in Schizophrenia

Exploring Brain Stimulation as a Treatment for Auditory Hallucinations in Schizophrenia

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The authors pointed to a possible difference in the specific symptoms alleviated by different types of stimulation.

Recovery From First-Episode Psychosis More Likely in Those With Mania, Brief Psychosis Diagnoses

Recovery From First-Episode Psychosis More Likely in Those With Mania, Brief Psychosis Diagnoses

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The early sustained recovery group was more likely to have a diagnosis other than schizophrenia, particularly mania or brief psychosis.

Negative Symptoms Increase Cardiovascular Risk in Schizophrenia

Negative Symptoms Increase Cardiovascular Risk in Schizophrenia

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Although various clinical and psychosocial factors were associated with unhealthy lifestyle factors and higher risk for CVD, the strongest associations were with negative symptoms.

Improving Performance of Everyday Activities Is Critical in Schizophrenia

Improving Performance of Everyday Activities Is Critical in Schizophrenia

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Treatment beyond antipsychotic drugs is needed for people with schizophrenia, as positive symptoms are a peripheral node in the network.

Independent Risk Pathways Shown for Diabetes and Obesity in Adults With Serious Mental Illness

Independent Risk Pathways Shown for Diabetes and Obesity in Adults With Serious Mental Illness

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Given the high risk for metabolic disorder and type 2 diabetes, clinicians should select psychotropic medications carefully and monitor metabolic conditions regularly in their patients with serious mental illness.

Adjunctive Raloxifene May Improve Psychotic Symptoms in Postmenopausal Women With Schizophrenia

Adjunctive Raloxifene May Improve Psychotic Symptoms in Postmenopausal Women With Schizophrenia

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The meta-analysis showed raloxifene to be effective for positive symptoms, negative symptoms, and general psychopathology, with greatly homogeneous results.

Plasma Autoantibodies Possible Biomarker for Schizophrenia

Plasma Autoantibodies Possible Biomarker for Schizophrenia

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Investigators selected 15 genes associated with schizophrenia due to high expression in both brain tissue and B-lymphocyte cells.

Virtual Reality Can Reduce Anxiety, Improve Social Interactions in Psychosis

Virtual Reality Can Reduce Anxiety, Improve Social Interactions in Psychosis

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Use of virtual reality environments in which participants interact with computer-controlled situations or avatars enables a more fine-tuned approach to exposure in the context of cognitive behavioral therapy.

Transcranial Direct Current Stimulation May Improve Motor Learning in Nonclinical Psychosis

Transcranial Direct Current Stimulation May Improve Motor Learning in Nonclinical Psychosis

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tDCS may be an important tool for further improving our understanding of psychosis and designing targeted treatments.

First-Episode Schizophrenia: Searching for the Most Effective Atypical Antipsychotic

First-Episode Schizophrenia: Searching for the Most Effective Atypical Antipsychotic

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Researchers examined which atypical antipsychotic was more effective and safe in first-episode drug-naive schizophrenia.

Atypical Antipsychotic Pharmacokinetics

A chart outlining the pharmacokinetics of atypical antipsychotics, including information on bioavailability, half-life and CYP 450 metabolism.

Examining the Benefit of Benzodiazepines for Psychosis-Associated Aggression, Agitation

Examining the Benefit of Benzodiazepines for Psychosis-Associated Aggression, Agitation

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A meta-analysis of randomized, controlled trials compared the use of benzodiazepines alone or in combination with antipsychotic or antihistamine medications in patients experiencing acute psychotic illness.

Psychosis Associated With Increased Complications Following Total Joint Arthroplasty

Psychosis Associated With Increased Complications Following Total Joint Arthroplasty

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Investigators seek the association between psychosis and complication risk after total joint arthroplasty.

Suppression of Auditory Stimuli Associated With Pathologic Symptoms of Schizophrenia

Suppression of Auditory Stimuli Associated With Pathologic Symptoms of Schizophrenia

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P50 processing may inform researchers in the future development of interventions targeting cognitive impairment in schizophrenia.

Daily Dose Thresholds: Antipsychotics

A chart with daily dose thresholds for antipsychotic medications.

Advanced Paternal Age Associated With Development of Schizophrenia, Mental Disorders

Advanced Paternal Age Associated With Development of Schizophrenia, Mental Disorders

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Investigators seek the association between the risk of developing schizophrenia and advanced maternal and paternal age.

Subtle Gender Differences in Self-Perceived Symptoms of First-Episode Psychosis

Subtle Gender Differences in Self-Perceived Symptoms of First-Episode Psychosis

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Gender differences may predict the types of symptoms and age of onset of schizophrenic psychosis.

Cardiovascular, Metabolic Biomarker Assessment in Early Psychosis

Cardiovascular, Metabolic Biomarker Assessment in Early Psychosis

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Investigators assessed biomarkers for cardiovascular risk and protection in individuals with first-episode psychosis.

Effects of Social Recovery Therapy on Functional Outcomes in First-Episode Psychosis

Effects of Social Recovery Therapy on Functional Outcomes in First-Episode Psychosis

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Investigators believe social recovery therapy may benefit individuals with complex comorbidities not motivated to participate in psychosocial interventions targeting functioning after first-episode psychosis.

Examining the Potential of Neuroanatomical Imaging Signature for Schizophrenia Biomarkers

Examining the Potential of Neuroanatomical Imaging Signature for Schizophrenia Biomarkers

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Technique validation suggested a robust generalizability of neuroanatomical imaging in schizophrenia.

FDA Approves Schizophrenia Medication With Digital Ingestion Sensor

FDA Approves Schizophrenia Medication With Digital Ingestion Sensor

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The ability to track ingestion of medications prescribed for mental illness may be useful for some patients.

Diabetes Risk for Children, Young Adults on Second-Generation Antipsychotics

Diabetes Risk for Children, Young Adults on Second-Generation Antipsychotics

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Type 2 diabetes is greater with second-generation antipsychotics than with non-second-generation antipsychotic psychotropic medications for patients aged 6 to 25 years.

FDA Issues Refusal to File Letter in Response to New Schizophrenia Drug

FDA Issues Refusal to File Letter in Response to New Schizophrenia Drug

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The FDA issued a refusal to file letter for a new drug application.

Guidance for Managing Treatment-Resistant Schizophrenia

Guidance for Managing Treatment-Resistant Schizophrenia

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Different clinical and neurobiologic pathways may be involved in treatment-resistant schizophrenia as it is not a homogeneous subgroup within the schizophrenia spectrum.

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