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Reserpine
Hypertension
Psychosis
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Drug Name:

Reserpine Rx

Generic Name and Formulations:
Reserpine 0.1mg, 0.25mg; tabs.

Company:
Sandoz

Therapeutic Use:

Indications for Reserpine:

Mild essential hypertension. Adjunctive therapy with other antihypertensive agents in more severe forms of hypertenstion.

Adult:

Usual initial dose: 0.5mg daily for 1 or 2 weeks. Maintenance: reduce to 0.1–0.25mg daily.

Children:

Usually not recommended; if used, starting dose: 20mcg/kg daily; max 0.25mg daily.

Contraindications:

Depression or history of (esp. with suicidal tendencies). Active peptic ulcer. Ulcerative colitis. Electroconvulsive therapy.

Warnings/Precautions:

Discontinue at first signs of depression. History of peptic ulcer, ulcerative colitis, gallstones (biliary colic may be precipitated). Renal impairment. Surgery. Pregnancy (Cat.C). Nursing mothers: not recommended.

Interactions:

MAOIs: avoid or use with extreme caution. Concomitant tricyclics may decrease antihypertensive effects. May potentiate direct-acting amines (eg, epinephrine, isoproterenol, phenylephrine, metaraminol). May antagonize indirect-acting amines (eg, ephedrine, tyramine, amphetamines). Caution with digoxin, quinidine, other antihypertensive agents.

Pharmacological Class:

Rauwolfia compound.

Adverse Reactions:

GI upset, dry mouth, hypersecretion, arrhythmias, syncope, angina-like symptoms, bradycardia, edema, dyspnea, epistaxis, nasal congestion, dizziness, headache, paradoxical anxiety, depression, nervousness, nightmares, dull sensorium, drowsiness, muscle aches, pseudolactation, impotence, dysuria, gynecomastia, decreased libido, weight gain, deafness, optic atrophy, glaucoma, uveitis, conjunctival injection, purpura, rash, pruritus; rare: parkinsonian syndrome and other extrapyramidal symptoms.

How Supplied:

Tabs—100, 1000, 5000

Indications for Reserpine:

Relief of symptoms in agitated psychotic states (eg, schizophrenia), primarily in those unable to tolerate phenothiazine derivatives or in those who require antihypertensive medication.

Adult:

Individualize. Usual initial dose: 0.5mg daily, may range from 0.1–1mg.

Children:

Not recommended.

Contraindications:

Depression or history of (esp. with suicidal tendencies). Active peptic ulcer. Ulcerative colitis. Electroconvulsive therapy.

Warnings/Precautions:

Discontinue at first signs of depression. History of peptic ulcer, ulcerative colitis, gallstones (biliary colic may be precipitated). Renal impairment. Surgery. Pregnancy (Cat.C). Nursing mothers: not recommended.

Interactions:

MAOIs: avoid or use with extreme caution. Concomitant tricyclics may decrease antihypertensive effects. May potentiate direct-acting amines (eg, epinephrine, isoproterenol, phenylephrine, metaraminol). May antagonize indirect-acting amines (eg, ephedrine, tyramine, amphetamines). Caution with digoxin, quinidine, other antihypertensive agents.

Pharmacological Class:

Rauwolfia compound.

Adverse Reactions:

GI upset, dry mouth, hypersecretion, arrhythmias, syncope, angina-like symptoms, bradycardia, edema, dyspnea, epistaxis, nasal congestion, dizziness, headache, paradoxical anxiety, depression, nervousness, nightmares, dull sensorium, drowsiness, muscle aches, pseudolactation, impotence, dysuria, gynecomastia, decreased libido, weight gain, deafness, optic atrophy, glaucoma, uveitis, conjunctival injection, purpura, rash, pruritus; rare: parkinsonian syndrome and other extrapyramidal symptoms.

How Supplied:

Tabs—100, 1000, 5000

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