Research

Advancing Pain Management: Human Studies

Advancing Pain Management: Human Studies

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Research on monogenic disorders has made vital contributions to all aspects of medical care, including our understanding of pain pathophysiology.

NIH Announces New Investment In BRAIN Initiative

NIH Announces New Investment In BRAIN Initiative

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The NIH is awarding more than 100 new grants to over 170 researchers at 60 institutions that will total more than $70 million.

Big Data, Big Psychiatry — Big Potential?

Big Data, Big Psychiatry — Big Potential?

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You have probably heard the term 'Big Data' being bandied around, but what does it actually mean for the psychiatry sector? Dr Nicola Davies explains what Big Data is, before exploring how it's currently being applied within psychiatry.

Synthetic Cannabinoid Drug Poisonings Surge

Synthetic Cannabinoid Drug Poisonings Surge

The increased use of synthetic cannabinoids presents a serious public health threat.

Meta-Analysis: Combination Therapy Most Effective in Adult OCD

Meta-Analysis: Combination Therapy Most Effective in Adult OCD

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The combination of behavioral and cognitive therapy approaches with medications is likely the most effective intervention for adults diagnosed with severe obsessive-compulsive disorder.

Long-term Marijuana Use Associated with Dampened Nucleus Accumbens Reward Response

Long-term Marijuana Use Associated with Dampened Nucleus Accumbens Reward Response

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Alterations in reward processing may increase users' risk of continued drug use and subsequent addiction.

Bipolar Disorder Linked With Gene Expression in Unexpected Brain Region

Bipolar Disorder Linked With Gene Expression in Unexpected Brain Region

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New findings underline the potential importance of signaling pathways in the striatum for understanding bipolar disorder pathophysiology.

Interactive Effects of Genotype and Childhood Adversity on Alcohol Consumption

Interactive Effects of Genotype and Childhood Adversity on Alcohol Consumption

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Early life trauma interacts with FKBP5 genotype to predict heavy alcohol consumption in college students.

Severe Cannabis Dependence and Blunted Striatal Dopamine Release: A Comorbidity Independent Effect

Severe Cannabis Dependence and Blunted Striatal Dopamine Release: A Comorbidity Independent Effect

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Chronic and severe cannabis-dependence is associated with deficits in striatal dopamine release.

Augmentation With Antidepressants in Schizophrenia Treatment Appears Safe and Efficacious

Augmentation With Antidepressants in Schizophrenia Treatment Appears Safe and Efficacious

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In terms of depressive and negative symptoms, in the present meta-analysis, researchers estimate that 1 in 9 patients with schizophrenia will improve with add-on antidepressants.

Striatal D1 and D2 Dopamine Receptor Activity Exert Opposite Influences on Alcohol Drinking

Striatal D1 and D2 Dopamine Receptor Activity Exert Opposite Influences on Alcohol Drinking

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Inhibition of D1 dopamine receptors in medium spiny neurons, or excitation of D1 dopamine receptors in medium spiny neurons, of the striatum, attenuated excessive alcohol consumption in mice.

Identifying Depression: How Accurate is the PHQ-2?

Identifying Depression: How Accurate is the PHQ-2?

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The accuracy of the PHQ-2 in identifying major depression is lower than originally thought.

Veteran Suicides Fuel Widespread Demands for Answers

Veteran Suicides Fuel Widespread Demands for Answers

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As the Congress, VA, CDC and the Obama Administration address the issue, recent neuroimaging studies point to effective diagnostic tools available for PTSD and TBI — two common conditions among suicide victims.

What Neuroimaging Can Teach us About Depression

What Neuroimaging Can Teach us About Depression

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Neuroimaging studies have shown several neurophysiological substrates for depression: An overview by Theodore Henderson, MD, PhD.

Do Adjunctive Neutraceuticals Help Relieve Depression?

Do Adjunctive Neutraceuticals Help Relieve Depression?

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Augmentation and combination approaches with pharmaceuticals are often used in clinical practice.

Ventral Pallidum Plays Active Role in Reward-Seeking Behavior

Ventral Pallidum Plays Active Role in Reward-Seeking Behavior

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Pharmacological and optogenetic inhibition of ventral pallidum neurons during cue presentation impedes reward-seeking behavior.

TrendMD: Effectively Navigating the Biomedical Research Landscape

TrendMD: Effectively Navigating the Biomedical Research Landscape

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New platform helps clinicians bridge the gap in translation of knowledge from bench to bedside.

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