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REGLAN
Hyperacidity, GERD, and ulcers
Nausea
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Drug Name:

REGLAN Rx

Generic Name and Formulations:
Metoclopramide (as HCl) 5mg, +10mg; +scored tabs.

Company:
Ani Pharmaceuticals

Therapeutic Use:

Indications for REGLAN:

Symptomatic refractory GERD.

Adult:

10–15mg 4 times daily 30 minutes before meals and at bedtime. Intermittent symptoms, up to 20mg prior to provoking situation; max 12 weeks per therapeutic course. Renal impairment: reduce dose.

Children:

Not recommended.

Contraindications:

When stimulation of GI motility may be dangerous (eg, obstruction, perforation, or hemorrhage). Pheochromocytoma. Epilepsy. Concomitant drugs which may cause extrapyramidal reactions (eg, phenothiazines, haloperidol).

Warnings/Precautions:

Parkinsonism. Tardive dyskinesia. History of breast cancer or depression. Cirrhosis. CHF. Hypertension. Elderly. Pregnancy (Cat.B). Nursing mothers.

Interactions:

Hypertensive crisis with MAOIs. Additive sedation with alcohol, other CNS depressants. Antagonized by anticholinergics and narcotics. Monitor insulin use; may diminish gastric and accelerate intestinal absorption of drugs or food.

Pharmacological Class:

Prokinetic.

Adverse Reactions:

Restlessness, drowsiness, fatigue, extrapyramidal effects, parkinsonism, tardive dyskinesia, neuroleptic malignant syndrome, dizziness, endocrine disturbances, hypo- or hypertension, fluid retention, GI or GU disturbances; rare: hepatotoxicity.

How Supplied:

Tabs—100

Indications for REGLAN:

Nausea and vomiting associated with diabetic gastroparesis.

Adult:

10mg 30 minutes before each meal and at bedtime for 2–8 weeks. Renal impairment: reduce dose.

Children:

Not recommended.

Contraindications:

When stimulation of GI motility may be dangerous (eg, obstruction, perforation, or hemorrhage). Pheochromocytoma. Epilepsy. Concomitant drugs which may cause extrapyramidal reactions (eg, phenothiazines, haloperidol).

Warnings/Precautions:

Parkinsonism. Tardive dyskinesia. History of breast cancer or depression. Cirrhosis. CHF. Hypertension. Elderly. Pregnancy (Cat.B). Nursing mothers.

Interactions:

Hypertensive crisis with MAOIs. Additive sedation with alcohol, other CNS depressants. Antagonized by anticholinergics and narcotics. Monitor insulin use; may diminish gastric and accelerate intestinal absorption of drugs or food.

Pharmacological Class:

Antidopaminergic.

Adverse Reactions:

Restlessness, drowsiness, fatigue, extrapyramidal effects, parkinsonism, tardive dyskinesia, neuroleptic malignant syndrome, dizziness, endocrine disturbances, hypo- or hypertension, fluid retention, GI or GU disturbances; rare: hepatotoxicity.

How Supplied:

Tabs—100

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