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Quinidine gluconate
CHF and arrhythmias
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Drug Name:

Quinidine gluconate Rx

Generic Name and Formulations:
Quinidine gluconate 324mg; ext-rel tabs.

Company:
Various generic manufacturers

Therapeutic Use:

Indications for Quinidine gluconate:

Atrial and ventricular arrhythmias (see literature).

Adult:

Take with fluid and in an upright position. Individualize. Prevention of premature atrial, nodal and ventricular contractions: 324–648mg every 8–12 hrs. Maintenance of sinus rhythm following cardioversion: 648mg every 12 hrs or 486–648mg every 8 hrs.

Children:

Not recommended.

Contraindications:

Complete AV or bundle branch block or other severe intraventricular conduction defects. Myasthenia gravis. Digitalis intoxication. Aberrant impulses, abnormal rhythms due to escape mechanisms.

Warnings/Precautions:

Atrial flutter; digitalize first. Incomplete AV block. Heart failure. Marginally compensated cardiovascular disease. Hypotension. Renal and hepatic dysfunction. Monitor blood, liver and kidney function in long-term use. Monitor ECG and serum levels if dose is over 2.5g/day. Pregnancy (Cat.C). Nursing mothers.

Interactions:

Quinidine toxicity increased by amiodarone, cimetidine, ranitidine, diuretics, carbonic anhydrase inhibitors, sodium bicarbonate, verapamil, diltiazem. Potentiates anticoagulants, anticholinergics, neuromuscular blocking agents, phenothiazines, reserpine, timolol. Increases digitalis serum levels. Quinidine levels decreased by barbiturates, hydantoins, rifampin, nifedipine.

Pharmacological Class:

Class I antiarrhythmic.

Adverse Reactions:

Nausea, vomiting, abdominal pain, diarrhea, new or exacerbated arrhythmias, heart block, syncope, cinchonism, headache, blood dyscrasias, hypotension, flushing, allergic reactions, impaired hearing and vision, hepatic dysfunction.

Note:

Formerly known under the brand names Duraquin, Quinact, Quinaglute.

How Supplied:

Contact supplier.

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