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Pyrazinamide
Tuberculosis
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Drug Name:

Pyrazinamide Rx

Generic Name and Formulations:
Pyrazinamide 500mg; scored tabs.

Company:
Various generic manufacturers

Therapeutic Use:

Indications for Pyrazinamide:

Susceptible pulmonary tuberculosis.

Adults and Children:

15–30mg/kg once daily; max 2g daily. Or 50–70mg/kg twice weekly based on lean body weight.

Contraindications:

Severe hepatic damage. Acute gout.

Warnings/Precautions:

Use with other antituberculars. Monitor hepatic function and serum uric acid before and during therapy. Hepatocellular damage or hyperuricemia with acute gouty arthritis: discontinue. Patients at risk for hepatitis (eg, alcoholism). Diabetes (blood glucose may be harder to control). HIV: see literature. Pregnancy (Cat.C). Nursing mothers.

Interactions:

May interfere with Acetest or Ketostix.

Pharmacological Class:

Nicotinamide analogue.

Adverse Reactions:

Hepatitis, liver dysfunction, gout, GI disturbances, arthralgia, myalgia, blood dyscrasias (rare).

How Supplied:

Contact supplier.

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