Psychosis

Mortality Rates in Parkinson Disease Psychosis With Pimavanserin, Quetiapine

Mortality Rates in Parkinson Disease Psychosis With Pimavanserin, Quetiapine

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In patients with Parkinson disease psychosis, treatment with pimavanserin has a lower risk for mortality compared with quetiapine or combination therapy.

British Study Shows Cannabis Use Adversely Affects Individuals With Early Psychosis

British Study Shows Cannabis Use Adversely Affects Individuals With Early Psychosis

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Experimental studies have shown that the primary psychoactive ingredient in cannabis can induce psychotic symptoms in otherwise healthy individuals.

Reducing Off-Label Quetiapine Prescribing the Old-Fashioned Way: Snail Mail

Reducing Off-Label Quetiapine Prescribing the Old-Fashioned Way: Snail Mail

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Despite the associated risk for death and cognitive decline, "off-label" prescribing of antipsychotics in patients with dementia has increased.

Hyperprolactinemia and Insulin Resistance Associated With First-Episode Psychosis

Hyperprolactinemia and Insulin Resistance Associated With First-Episode Psychosis

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There was a significantly higher level of prolactin found in the first episode psychosis group than in the clinical high risk group, suggesting a condition of hyperprolactinemia.

Most Antipsychotics Prescribed in Nursing Homes Initiated There

Most Antipsychotics Prescribed in Nursing Homes Initiated There

Antipsychotic use was initiated 64% in nursing homes, 18.6% in hospitals, and 17.5% in outpatient settings.

Adolescent Inhalant Use Associated With Higher Risk for Psychosis

Adolescent Inhalant Use Associated With Higher Risk for Psychosis

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Inhalant and other substance use during adolescence are increasingly associated with many adverse health and psychosocial outcomes.

Memantine Plus Cholinesterase Inhibitors Improves Psychosis, Neurobehavioral Symptoms in Alzheimer Disease

Memantine Plus Cholinesterase Inhibitors Improves Psychosis, Neurobehavioral Symptoms in Alzheimer Disease

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Investigators pooled data from patients from 3 phase 3, 24-week, randomized, placebo-controlled trials of MEM in patients with Alzheimer disease receiving concurrent ChEIs.

Long-Acting Injectables Effective in Patients With Comorbid Psychosis, Substance Use Disorder

Long-Acting Injectables Effective in Patients With Comorbid Psychosis, Substance Use Disorder

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As psychosis and substance use disorder comorbidity can make oral medication adherence difficult, long-acting injectable agents may be an effective therapeutic alternative in patients in this demographic.

Psychotic Experiences Associated With Increased Risk for Eating Disorders in Adolescents

Psychotic Experiences Associated With Increased Risk for Eating Disorders in Adolescents

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These data suggest the need for targeted interventions in children with psychotic experiences to prevent disordered eating behaviors in later adolescence.

Population-Wide Folic Acid Fortification May Protect Against Psychosis

Population-Wide Folic Acid Fortification May Protect Against Psychosis

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Protective effects of prenatal folic acid exposure may extend beyond prevention of neural tube defects and span neurodevelopment during childhood and adolescence.

Atypical Antipsychotic Use and CV Events in Youth: What's the Link?

Atypical Antipsychotic Use and CV Events in Youth: What's the Link?

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Atypical antipsychotic use was associated with a higher risk for cardiovascular events among publicly insured youth in the US.

Exploring Physical Activity Trends in Youth at Clinically High Risk for Psychosis

Exploring Physical Activity Trends in Youth at Clinically High Risk for Psychosis

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Treatment modes targeting motivation may be effective in promoting exercise in youth at clinically high risk for psychosis.

Cannabis Use in Adolescents Associated With Symptoms of Psychosis

Cannabis Use in Adolescents Associated With Symptoms of Psychosis

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The association of cannabis use with symptoms of psychosis underscores the need for targeted cannabis use prevention.

Cannabis Use Linked to Psychosis Symptoms in Adolescents

Cannabis Use Linked to Psychosis Symptoms in Adolescents

Cannabis use is associated with psychosis symptoms during adolescence.

Visual Integration Impairment Characteristic of Psychosis, Not Specific to Schizophrenia

Visual Integration Impairment Characteristic of Psychosis, Not Specific to Schizophrenia

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These results indicate that impaired visual integration in patients with schizophrenia may more broadly be a feature of psychosis, rather than specifically of schizophrenia.

Early Intervention Services Superior to Treatment as Usual for Early-Phase Psychosis

Early Intervention Services Superior to Treatment as Usual for Early-Phase Psychosis

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The superior benefit provided by early intervention services for schizophrenia could be cost-effective, and the researchers call for widespread implementation and funding of early intervention services in the United States and globally.

Valproate Use in Women Who Could Become Pregnant: The Argument for Informed Consent

Valproate Use in Women Who Could Become Pregnant: The Argument for Informed Consent

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There is currently no international agreement on the appropriate regulation of valproate in people who may become pregnant.

Gyrification-Based Connectomes Appear Promising for Predicting Transition to Psychosis

Gyrification-Based Connectomes Appear Promising for Predicting Transition to Psychosis

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To date, there has been limited prognostic accuracy of clinical instruments in predicting the onset of psychosis and no reliable biological marker has been identified.

Antipsychotics Increase Risk for Metabolic Syndrome, CVD in Younger Patients

Antipsychotics Increase Risk for Metabolic Syndrome, CVD in Younger Patients

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Younger patients treated with antipsychotics after experiencing a first episode of psychosis are at an increased risk for metabolic syndrome and cardiovascular disease.

Mortality in Alzheimer Disease Not Strongly Associated With Antipsychotics

Mortality in Alzheimer Disease Not Strongly Associated With Antipsychotics

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These results suggest that antipsychotic exposure has no impact on relative mortality.

Acadia Addresses Concerns Over Nuplazid Safety in Parkinson Disease Patients

Acadia Addresses Concerns Over Nuplazid Safety in Parkinson Disease Patients

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Concerns over Nuplazid were initially voiced in a CNN article in early April which reported that the drug had been associated with over 700 deaths since its launch in March 2017.

Sleep Disturbances, Trauma Associated With Psychosis-Like Experiences

Sleep Disturbances, Trauma Associated With Psychosis-Like Experiences

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These findings may be helpful in developing treatment strategies for patients with past trauma and sleep disturbances to attenuate the possibility of future psychosis-like experiences.

Children of Consanguineous Marriage at Increased Risk for Mood Disorders, Psychoses

Children of Consanguineous Marriage at Increased Risk for Mood Disorders, Psychoses

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Communities that favor consanguineous marriage should receive sensitive advice on the risks involved to aid in reproductive decision making.

Childhood Insulin Resistance Associated With Later Psychosis

Childhood Insulin Resistance Associated With Later Psychosis

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The authors advised clinicians to carefully consider which antipsychotics they prescribe their patients with metabolic dysfunction, as some are known to be diabetogenic.

Association Between Psychosis and Development of Dementia in Older Men

Association Between Psychosis and Development of Dementia in Older Men

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The findings also suggested that more a more recent diagnosis of psychosis was a greater predictor of the development of dementia, as opposed to cases where patients had been living with psychotic disorder diagnoses for 10 years or more.

Psychosis Could Be a Potential Side Effect of Steroid Treatment in Kids

Psychosis Could Be a Potential Side Effect of Steroid Treatment in Kids

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Iatrogenic steroid-induced psychosis is a rare side effect of glucocorticoid therapy which is mostly seen in adults, although it has been reported in children and adolescents.

Recovery From First-Episode Psychosis More Likely in Those With Mania, Brief Psychosis Diagnoses

Recovery From First-Episode Psychosis More Likely in Those With Mania, Brief Psychosis Diagnoses

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The early sustained recovery group was more likely to have a diagnosis other than schizophrenia, particularly mania or brief psychosis.

Old Challenges and New Directions in Managing Tardive Dyskinesia

Old Challenges and New Directions in Managing Tardive Dyskinesia

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"Since the current generation of psychiatrists has been raised on second-generation antipsychotics and has relatively little experience with first-generation antipsychotics, keeping tardive dyskinesia in mind is not, on the whole, part of their experience or training," said Christoph U. Correll, MD.

Cognitive Impairment May Predict Persistent Psychosis in Ketamine Users

Cognitive Impairment May Predict Persistent Psychosis in Ketamine Users

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Ketamine-dependent patients who exhibited psychosis demonstrated levels of spatial problem solving and verbal memory impairment similar to those of patients with schizophrenia.

Heavy Cigarette Smoking in Adolescence May Increase Risk for Psychosis

Heavy Cigarette Smoking in Adolescence May Increase Risk for Psychosis

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Despite the recognition that early daily tobacco use likely increases the risk for later psychosis, investigation of the effect of covariates such as substance use, existing psychotic features, or parental/family factors was lacking in the literature.

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