Psychosis

Early Intervention Services Superior to Treatment as Usual for Early-Phase Psychosis

Early Intervention Services Superior to Treatment as Usual for Early-Phase Psychosis

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The superior benefit provided by early intervention services for schizophrenia could be cost-effective, and the researchers call for widespread implementation and funding of early intervention services in the United States and globally.

Valproate Use in Women Who Could Become Pregnant: The Argument for Informed Consent

Valproate Use in Women Who Could Become Pregnant: The Argument for Informed Consent

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There is currently no international agreement on the appropriate regulation of valproate in people who may become pregnant.

Gyrification-Based Connectomes Appear Promising for Predicting Transition to Psychosis

Gyrification-Based Connectomes Appear Promising for Predicting Transition to Psychosis

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To date, there has been limited prognostic accuracy of clinical instruments in predicting the onset of psychosis and no reliable biological marker has been identified.

Antipsychotics Increase Risk for Metabolic Syndrome, CVD in Younger Patients

Antipsychotics Increase Risk for Metabolic Syndrome, CVD in Younger Patients

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Younger patients treated with antipsychotics after experiencing a first episode of psychosis are at an increased risk for metabolic syndrome and cardiovascular disease.

Mortality in Alzheimer Disease Not Strongly Associated With Antipsychotics

Mortality in Alzheimer Disease Not Strongly Associated With Antipsychotics

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These results suggest that antipsychotic exposure has no impact on relative mortality.

Acadia Addresses Concerns Over Nuplazid Safety in Parkinson Disease Patients

Acadia Addresses Concerns Over Nuplazid Safety in Parkinson Disease Patients

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Concerns over Nuplazid were initially voiced in a CNN article in early April which reported that the drug had been associated with over 700 deaths since its launch in March 2017.

Sleep Disturbances, Trauma Associated With Psychosis-Like Experiences

Sleep Disturbances, Trauma Associated With Psychosis-Like Experiences

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These findings may be helpful in developing treatment strategies for patients with past trauma and sleep disturbances to attenuate the possibility of future psychosis-like experiences.

Children of Consanguineous Marriage at Increased Risk for Mood Disorders, Psychoses

Children of Consanguineous Marriage at Increased Risk for Mood Disorders, Psychoses

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Communities that favor consanguineous marriage should receive sensitive advice on the risks involved to aid in reproductive decision making.

Childhood Insulin Resistance Associated With Later Psychosis

Childhood Insulin Resistance Associated With Later Psychosis

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The authors advised clinicians to carefully consider which antipsychotics they prescribe their patients with metabolic dysfunction, as some are known to be diabetogenic.

Association Between Psychosis and Development of Dementia in Older Men

Association Between Psychosis and Development of Dementia in Older Men

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The findings also suggested that more a more recent diagnosis of psychosis was a greater predictor of the development of dementia, as opposed to cases where patients had been living with psychotic disorder diagnoses for 10 years or more.

Psychosis Could Be a Potential Side Effect of Steroid Treatment in Kids

Psychosis Could Be a Potential Side Effect of Steroid Treatment in Kids

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Iatrogenic steroid-induced psychosis is a rare side effect of glucocorticoid therapy which is mostly seen in adults, although it has been reported in children and adolescents.

Recovery From First Episode Psychosis More Likely in Those With Mania, Brief Psychosis Diagnoses

Recovery From First Episode Psychosis More Likely in Those With Mania, Brief Psychosis Diagnoses

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The early sustained recovery group was more likely to have a diagnosis other than schizophrenia, particularly mania or brief psychosis.

Old Challenges and New Directions in Managing Tardive Dyskinesia

Old Challenges and New Directions in Managing Tardive Dyskinesia

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"Since the current generation of psychiatrists has been raised on second-generation antipsychotics and has relatively little experience with first-generation antipsychotics, keeping tardive dyskinesia in mind is not, on the whole, part of their experience or training," said Christoph U. Correll, MD.

Cognitive Impairment May Predict Persistent Psychosis in Ketamine Users

Cognitive Impairment May Predict Persistent Psychosis in Ketamine Users

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Ketamine-dependent patients who exhibited psychosis demonstrated levels of spatial problem solving and verbal memory impairment similar to those of patients with schizophrenia.

Heavy Cigarette Smoking in Adolescence May Increase Risk for Psychosis

Heavy Cigarette Smoking in Adolescence May Increase Risk for Psychosis

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Despite the recognition that early daily tobacco use likely increases the risk for later psychosis, investigation of the effect of covariates such as substance use, existing psychotic features, or parental/family factors was lacking in the literature.

Infection in First Year Has Greatest Effect on IQ, Nonaffective Psychosis

Infection in First Year Has Greatest Effect on IQ, Nonaffective Psychosis

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Investigators determined infections in the first year of life to be the "sensitive period" for risk of adult nonaffective psychosis.

Children Bullied by Sibling at Increased Risk of Developing a Psychotic Disorder

Children Bullied by Sibling at Increased Risk of Developing a Psychotic Disorder

Children who are involved in sibling bullying are at a higher risk of developing a psychotic disorder.

Patterns of Healthcare Use Before Diagnosis of Psychotic Disorders in Young Adults

Patterns of Healthcare Use Before Diagnosis of Psychotic Disorders in Young Adults

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Most people receiving a first diagnosis of a psychotic disorder have had some indication of mental health need in the previous year.

Virtual Reality Can Reduce Anxiety, Improve Social Interactions in Psychosis

Virtual Reality Can Reduce Anxiety, Improve Social Interactions in Psychosis

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Use of virtual reality environments in which participants interact with computer-controlled situations or avatars enables a more fine-tuned approach to exposure in the context of cognitive behavioral therapy.

Addition of SSRIs to Antipsychotics Has Only Minor Impact on Metabolic Risk Factors

Addition of SSRIs to Antipsychotics Has Only Minor Impact on Metabolic Risk Factors

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A combination of an SSRI and antipsychotics in a clinical setting most likely does not lead to a further deterioration of metabolic variables to a clinically significant degree.

Examining the Benefit of Benzodiazepines for Psychosis-Associated Aggression, Agitation

Examining the Benefit of Benzodiazepines for Psychosis-Associated Aggression, Agitation

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A meta-analysis of randomized, controlled trials compared the use of benzodiazepines alone or in combination with antipsychotic or antihistamine medications in patients experiencing acute psychotic illness.

Psychosis Treatment Failure More Common in Patients With ASD

Psychosis Treatment Failure More Common in Patients With ASD

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Multiple treatment failure in children with first-episode psychosis was more common among patients with comorbid autism spectrum disorders.

Higher Rates of Psychotic Disorders in Younger Men, Racial Minorities

Higher Rates of Psychotic Disorders in Younger Men, Racial Minorities

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The treated incidence of psychotic disorders was shown to range from 6.0 to 46.1 per 100,000 person-years across various regions.

Peer Review Policy Leads to Decreased Use of Atypical Antipsychotics in Children

Peer Review Policy Leads to Decreased Use of Atypical Antipsychotics in Children

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The use of atypical antipsychotics can be reduced with the implementation of a peer review prior authorization policy.

Depression, Psychosis High Among Factors Leading to Surgical Readmission

Depression, Psychosis High Among Factors Leading to Surgical Readmission

Patient behavior is affected with factors associated with readmission in THA patients.

Persistent Negative Symptoms in First-Episode Psychosis Associated With Early Onset of Disease

Persistent Negative Symptoms in First-Episode Psychosis Associated With Early Onset of Disease

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These findings suggest that there are critical periods of development associated with a higher risk of persistent negative symptoms.

Childhood Maltreatment Associated With Increased Risk of Psychosis in Ultra-High Risk Individuals

Childhood Maltreatment Associated With Increased Risk of Psychosis in Ultra-High Risk Individuals

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Child maltreatment is significantly more prevalent in young individuals who present with UHR symptoms compared with controls.

Underlying Mechanism of Auditory Impairment in Schizophrenia Reveals Potential Therapeutic Path

Underlying Mechanism of Auditory Impairment in Schizophrenia Reveals Potential Therapeutic Path

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Benefits of NMDA receptor agonists in patients with schizophrenia include improvements with memory and reading.

Significant Cognitive Impairment in Those At High Risk of Psychosis

Significant Cognitive Impairment in Those At High Risk of Psychosis

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Studying cognition deficits during the clinical high risk period allows researchers to observe cognitive defects before chronicity and long-term medication use obscure the core deficits.

Low Levels of Vitamin D in Patients With Bipolar Disorder

Low Levels of Vitamin D in Patients With Bipolar Disorder

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Approximately 2.5% of people worldwide are estimated to have bipolar spectrum disorders, which are a significant cause of neuropsychiatric disability.

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