PROSTIN E2 Rx
Generic Name and Formulations:
Dinoprostone 20mg; per vaginal suppository.
Indications for PROSTIN E2:
For the termination of pregnancy from the 12th through the 20th gestational weeks. For the evacuation of the uterine contents in the management of missed abortion or intrauterine fetal death up to 28 weeks of gestational age. Management of nonmetastatic gestational trophoblastic disease (benign hydatidiform mole).
Insert one supp high into vagina. Remain in supine position for 10mins following insertion. May insert subsequent supp at 3–5hr intervals until abortion occurs. Continuous administration for more than 2 days is not recommended.
Acute pelvic inflammatory disease. Active cardiac, pulmonary, renal or hepatic disease.
Only use with strict adherence to recommended dosages. Should only be used by medically trained personnel in a hospital setting.
Not indicated if fetus in utero has reached the stage of viability. Not for use in cervical ripening or other indication in patients with term pregnancy. Asthma. Hypo-or hypertension. Anemia. Jaundice. Diabetes. Epilepsy. History of cardiac, renal, or hepatic disease. Cervicitis. Infected endocervical lesions. Acute vaginitis. Compromised (scarred) uteri. Remove supp if hypersensitivity reaction is suspected. Pregnancy.
Concomitant other oxytocic agents: not recommended.
Vomiting, transient pyrexia (see full labeling re: PGEs induced pyrexia vs. endometritis pyrexia), diarrhea, nausea, headache, chills, transient decrease in BP; MI in patients with history of CVD, hypersensitivity.
Sign Up for Free e-newsletters
Psychiatry Advisor Articles
- Nomophobia: The Modern-Day Pathology
- Transdermal Nicotine Boosts Mood and Cognitive Function in Late-Life Depression
- Emerging Theories in the Pathophysiology of MDD: Could the Opioid System Be Involved?
- Ketamine Infusions Reduce Suicidal Ideation in Depression: Characterizing Different Responses
- Combination Cognitive Behavioral Therapy With Fluoxetine Effective for Adolescent Depression
- Text Message Reminders Improve Medication Adherence in Bipolar I Disorder
- Improving Medication Adherence in ADHD Lowers Risk for Oppositional Defiant Disorder, Conduct Disorder in Adulthood
- High Suicidality Among Children With ADHD Mediated by Family Functioning, Psychiatry Comorbidities
- Pilot Study Investigates Lithium vs Quetiapine for Bipolar Spectrum Disorder
- How Personalized Hospital Ratings May Drive Patient-Specific Care in the Digital Age