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Propranolol HCl Injection
CHF and arrhythmias
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Drug Name:

Propranolol HCl Injection Rx

Generic Name and Formulations:
Propranolol HCl 1mg/mL; soln for IV inj.

Company:
Various generic manufacturers

Therapeutic Use:

Indications for Propranolol HCl Injection:

Supraventricular arrhythmias (see literature). Ventricular tachycardias (not first-line). Tachyarrhythmias of digitalis intoxication. Resistant tachyarrythmias due to excessive catecholamine action during anesthesia.

Adult:

Usual dose: 1–3mg IV at a rate of 1mg/min. If necessary, a second dose may be given after 2 minutes. Thereafter, additional drug should not be given in less than 4 hours. Transfer to oral therapy as soon as possible.

Children:

Not recommended.

Contraindications:

Asthma. Sinus bradycardia. 2nd- or 3rd-degree AV block. Cardiogenic shock.

Warnings/Precautions:

CHF. Wolff-Parkinson-White syndrome. Renal or hepatic dysfunction. Bronchospastic disease, COPD. Diabetes. Hyperthyroidism. Surgery. Avoid abrupt cessation. Elderly. Pregnancy (Cat.C). Nursing mothers.

Interactions:

Potentiated by CNS depressants, other antihypertensives, haloperidol, propafenone, quinidine, disopyramide, amiodarone. Bradycardia with catecholamine-depleting drugs (eg, reserpine). Antagonized by NSAIDs, barbiturates, rifampin, phenytoin. Caution with drugs that slow A-V nodal conduction (eg, calcium channel blockers, digitalis, lidocaine). Potentiates theophylline, antipyrine, lidocaine. Antihypertensive effects of clonidine may be antagonized. Concomitant methoxyflurane, trichloroethylene may depress myocardial contractility. Concomitant thyroxine may result in lower T3 concentration. May block epinephrine. May interfere with glaucoma screening tests. Monitor prothrombin time with warfarin.

Pharmacological Class:

Beta-blocker.

Adverse Reactions:

Bradycardia, CHF, intensification of AV block, hypotension, CNS effects, GI upset, pharyngitis, rash, bronchospasm, blood dyscrasias; rare: SLE.

How Supplied:

Contact supplier.

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