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Propantheline bromide
Hyperacidity, GERD, and ulcers
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Drug Name:

Propantheline bromide Rx

Generic Name and Formulations:
Propantheline bromide 15mg; tabs.

Company:
Roxane Laboratories, Inc.

Therapeutic Use:

Indications for Propantheline bromide:

Adjunctive therapy in the treatment of peptic ulcer.

Adult:

15mg taken 30 minutes before each meal and 30mg at bedtime. Total daily dose: 75mg.

Children:

Not recommended.

Contraindications:

Glaucoma. GI obstruction (eg, pyloroduodenal stenosis, achalasia, paralytic ileus). GU obstruction (eg, bladder-neck obstruction due to prostatic hypertrophy). Intestinal atony of elderly or debilitated. Severe ulcerative colitis. Toxic megacolon. Unstable cardiovascular adjustment in acute hemorrhage. Myasthenia gravis.

Warnings/Precautions:

High environmental temperature. Monitor for diarrhea; may be symptom of incomplete intestinal obstruction. Heart disease. CHF. Cardiac tachyarrhythmias. Hypertension. Hiatal hernia associated with reflux esophagitis. Autonomic neuropathy. Hepatic or renal disease. Hyperthyroidism. Elderly. Pregnancy (Cat.C). Nursing mothers.

Interactions:

Additive anticholinergic effects with concomitant belladonna alkaloids, narcotic analgesics (eg, meperidine), Class I antiarrhythmics (eg, disopyramide, procainamide, quinidine), antihistamines, phenothiazines (may potentiated sedative effects), tricyclic antidepressants, other anticholinergics. Increased intraocular pressure with concomitant corticosteroids. May potentiate slow-dissolving digoxin tablets; use rapidly-dissolving digoxin tablets instead.

Pharmacological Class:

Anticholinergic.

Adverse Reactions:

Drying of salivary secretions, decreased sweating, ophthalmic effects (eg, blurred vision, mydriasis, cycloplegia, increased ocular tension), urinary hesitancy and retention, tachycardia, palpitations, loss of sense of taste, headache, nervousness, mental confusion, drowsiness, weakness, dizziness, insomnia, GI upset, constipation, bloating, impotence, lactation suppression, allergic reactions.

Note:

Formerly known under the brand name Pro-Banthine.

How Supplied:

Tabs—100

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