Generic Name and Formulations:
Trimethoprim (as HCl) 50mg/5mL; bubble-gum flavored soln; alcohol- and dye-free.
Aytu BioScience, Inc.
Indications for PRIMSOL:
Susceptible acute otitis media (AOM) due to S. pneumoniae or H. influenzae in children. Susceptible initial episodes of uncomplicated UTIs in adults.
UTIs: 100mg twice daily, or 200mg once daily; both for 10 days. Renal dysfunction: CrCl 15–30mL/min: reduce dose by ½; CrCl <15mL/min: not recommended.
<6months: not recommended. ≥6months: AOM: 10mg/kg daily in 2 divided doses every 12 hours for 10 days. Renal dysfunction: CrCl 15–30mL/min: reduce dose by ½; CrCl <15mL/min: not recommended.
Megaloblastic anemia due to folate deficiency.
Avoid large doses or prolonged administration (increased risk of blood disorders). Monitor CBC, discontinue if signs of blood disorders occur. Possible folate deficiency (may give folate concomitantly). Renal or hepatic impairment. Pregnancy (Cat.C). Nursing mothers.
Folic acid inhibitor.
May potentiate phenytoin. May interfere with some creatinine tests (alkaline picrate reduction).
Rash, GI upset, hematological or renal effects.
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