Pharmacotherapy

Methylphenidate & CBT Benefits TBI Patients with Cognitive Problems

Methylphenidate & CBT Benefits TBI Patients with Cognitive Problems

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These preliminary findings suggest that combined treatment with MAAT and methylphenidate can improve attention, episodic and working memory, and executive functioning following traumatic brain injury.

Issues With Clinical Trials That Impede New Pain Drug Development

Issues With Clinical Trials That Impede New Pain Drug Development

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The major issues of drug development are that pre-clinical animal efficacy studies do not accurately predict human efficacy, and clinical trials often inaccurately fail to show drug efficacy.

Efficacy of Lurasidone Assessed in Adolescents With Schizophrenia

Efficacy of Lurasidone Assessed in Adolescents With Schizophrenia

Sunovion have announced positive results from a study evaluating Latuda (lurasidone HCI) for the treatment of schizophrenia in adolescents aged 13 to 17 years old.

Predicting Placebo Response May Now be Possible

Predicting Placebo Response May Now be Possible

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Connectivity in the right midfrontal gyrus may help predict placebo response. This finding has widespread implications in drug development.

Memantine + Sertraline Effective Tx for Depression

Memantine + Sertraline Effective Tx for Depression

There was a significantly greater improvement in memantine group and a greater response rate at weeks 4 and 6.

Psych Meds Rx May Reduce Violent Reoffending in Ex-Prisoners

Psych Meds Rx May Reduce Violent Reoffending in Ex-Prisoners

Medications used to treat addiction cut the risk of reoffending in half.

Novel Opioids for Pain Relief

Novel Opioids for Pain Relief

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Researchers discovered novel opioid analgesics, displaying reduced respiratory depression.

Meta-Analysis: Combination Therapy Most Effective in Adult OCD

Meta-Analysis: Combination Therapy Most Effective in Adult OCD

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The combination of behavioral and cognitive therapy approaches with medications is likely the most effective intervention for adults diagnosed with severe obsessive-compulsive disorder.

What Neuroimaging Can Teach us About Depression

What Neuroimaging Can Teach us About Depression

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Neuroimaging studies have shown several neurophysiological substrates for depression: An overview by Theodore Henderson, MD, PhD.

Do Adjunctive Neutraceuticals Help Relieve Depression?

Do Adjunctive Neutraceuticals Help Relieve Depression?

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Augmentation and combination approaches with pharmaceuticals are often used in clinical practice.

FDA Warning: Antipsychotic Linked to Impulse-Control Problems

FDA Warning: Antipsychotic Linked to Impulse-Control Problems

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The FDA has mandated new warnings to include a list of compulsive behaviors.

ACP Recommends CBT Treatment for Chronic Insomnia Disorder

ACP Recommends CBT Treatment for Chronic Insomnia Disorder

American College of Physician researchers have released 2 recommendations for treatment of chronic insomnia disorder.

Atypical Antipsychotic Pharmacokinetics

A chart outlining the pharmacokinetics of atypical antipsychotics, including information on bioavailability, half-life and CYP 450 metabolism.

Antidepressant Bupropion Linked To Less Weight Gain

Antidepressant Bupropion Linked To Less Weight Gain

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Having more information on the long-term impact of antidepressants on weight could reduce the risk of weight-related morbidity for a large population of adults with depression.

Antipsychotics Ineffective for Delirium During Hospitalization

Antipsychotics Ineffective for Delirium During Hospitalization

No significant effect was found for preventing or treating delirium during hospitalization with antipsychotic medications.

ACP Recommendations Against Skyrocketing Costs of Prescriptions

ACP Recommendations Against Skyrocketing Costs of Prescriptions

The ACP recommends transparency in relation to pricing, costs, and comparative value.

SSRIs Found Not To Increase Risk of Cardiac Events in Depression

SSRIs Found Not To Increase Risk of Cardiac Events in Depression

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Neither a specific antidepressant class nor individual drugs had any influence on the risk of stroke or transient ischemic attack over all of follow-up.

Ketamine May Provide Lasting Relief From Depression

Ketamine May Provide Lasting Relief From Depression

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Treatment gives infusions of ketamine no more than once per week.

Improvements Needed in Treating Veterans With PTSD, Depression

Improvements Needed in Treating Veterans With PTSD, Depression

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The number and timing of follow-up psychotherapy visits may be inadequate to deliver evidence-based psychotherapy.

Review Explores Potential Harms of Antidepressant Treatment

Review Explores Potential Harms of Antidepressant Treatment

No significant risks were found in adults; the risk of suicidality and aggression doubled in children and teens.

FDA Approves Orally-Disintegrating Tablet for ADHD in Children

FDA Approves Orally-Disintegrating Tablet for ADHD in Children

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The bioequivalent of Adderall XR, the orally-disintegrating tablet Adzenys XR-ODT is an appealing option for treating ADHD in children.

Emergency Med Drug Shortages Increased 2008 to 2014

Emergency Med Drug Shortages Increased 2008 to 2014

Researchers found that 33.9% of the 1798 drug shortages were classified as within the scope of emergency medicine practice.

FDA Committee Favors Approval of Opioid Addiction Implant

FDA Committee Favors Approval of Opioid Addiction Implant

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Probuphine works like a contraceptive implant, with 4 small implanted rods that provide a steady amount of medication for up to 6 months.

Could Cholesterol-Lowering Drug Simvastatin Treat Parkinson's?

Could Cholesterol-Lowering Drug Simvastatin Treat Parkinson's?

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Results from a recent multiple sclerosis trial with simvastatin indicate that it could be an effective treatment to slow progression of Parkinson's.

Scientists a Step Closer to Treating Depression with Ketamine

Scientists a Step Closer to Treating Depression with Ketamine

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The activation of a brain pathway mimicked an antidepressant-like response to ketamine in mice.

'Rescued' Drug Could Be Safer Treatment for Bipolar Disorder

'Rescued' Drug Could Be Safer Treatment for Bipolar Disorder

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An abandoned drug for stroke treatment may provide a safer treatment than lithium in treating bipolar disorder.

Using Pharmacogenomics to Aid Antidepressant Prescribing

Using Pharmacogenomics to Aid Antidepressant Prescribing

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Matching drugs to patients based on genetic profiles can optimize medication selection and help avoid adverse effects.

Teens with Anxiety, Sleep Med Rxs More Prone to Substance Abuse

Teens with Anxiety, Sleep Med Rxs More Prone to Substance Abuse

Teens who have been prescribed anxiety or sleep medications are more likely to abuse them than those without prescriptions.

CBT Better Than Medication For Treating Social Anxiety Disorder

CBT Better Than Medication For Treating Social Anxiety Disorder

Meta-analysis finds cognitive-behavioral therapy best type of psychotherapy in treating SAD, and more efficacious than using drugs.

Avoiding Antipsychotic Polypharmacy in Schizophrenia

Avoiding Antipsychotic Polypharmacy in Schizophrenia

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Providers and patients may see better outcomes with simplified regimens.

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