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Drug Name:


Generic Name and Formulations:
Penicillin G potassium 5million Units, 20million Units (IV infusion only); per vial; pwd for IM, IV, intrapleural, intrathecal inj after reconstitution; contains sodium 6.8mg, potassium 65.6mg; per 1million Units.

Pfizer Inc.

Therapeutic Use:

Indications for PFIZERPEN:

Susceptible severe infections where rapid and high penicillin levels are required (see literature).

Adults and Children:

Bacteremia, pneumonia, endocarditis, pericarditis, empyema, meningitis, other severe infections (due to streptococci, pneumococci, staphylococci): minimum of 5million Units per day. Syphilis: dosage and duration determined by age of patient and stage of disease. Gonorrheal endocarditis: minimum 5million Units per day. Meningococcic meningitis: 1–2million Units IM every 2 hours, or continuous IV drip of 20–30million Units/day. Actinomycosis: 1–6million Units/day for cervicofacial cases; 10–20million Units/day for thoracic and abdominal disease. Clostridial infections: 20million Units/day as adjunctive therapy to antitoxin. Fusospirochetal infections: severe infections of oropharynx, lower respiratory tract, and genital area: 5–10million Units/day. Rat-bite fever: 12–15million Units/day for 3–4 weeks. Listeria infections: Neonates: 500,000–1million Units/day. Adults with meningitis: 15–20million Units/day for 2 weeks. Adults with endocarditis: 15–20million Units/day for 4 weeks. Pasteurella infections: Bacteremia and meningitis: 4–6million Units/day for 2 weeks. Ersipeloid: Endocarditis: 2–20million Units/day for 4–6 weeks. Gram-negative bacillary infections: Bacteremia: 20–80million Units/day. Diphtheria (carrier state): 300,000–400,000 Units/day in divided doses for 10–12 days. Anthrax: a minimum of 5million Units/day in divided doses until cure is effected. See literature re: prophylaxis of bacterial endocarditis in dental procedures.


Cephalosporin, imipenem, or other allergy: not recommended. Asthma. Electrolyte imbalance possible with rapid IV infusion; infuse slowly and monitor electrolytes frequently. Monitor renal, hepatic and hematopoietic function with long-term therapy. Newborns. Infants. Pregnancy (Cat.B). Nursing mothers.


Bacteriostatic antibiotics (eg, erythromycin, tetracycline) may diminish bactericidal effects. Potentiated by probenecid. May cause positive Coombs test.

Pharmacological Class:


Adverse Reactions:

Rash, drug fever, serum sickness, anaphylaxis, blood dyscrasias, neuropathy, nephropathy, inj site reactions.

How Supplied:

Vials (5million Units)—10; 20million Units—1

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