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Perphenazine
Nausea
Psychosis
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Drug Name:

Perphenazine Rx

Generic Name and Formulations:
Perphenazine 2mg, 4mg, 8mg, 16mg; tabs.

Company:
Various generic manufacturers

Therapeutic Use:

Indications for Perphenazine:

Severe nausea and vomiting.

Adult:

8–16mg/day in divided doses; may use 24mg, if needed. Reduce dose as soon as possible.

Children:

Not recommended.

Contraindications:

Coma. Concomitant large doses of CNS depressants. Blood dyscrasias. Bone marrow depression. Liver damage. Subcortical brain damage.

Warnings/Precautions:

CNS depression. Epilepsy. Cardiovascular disease. Respiratory disorders. History of breast cancer. Pheochromocytoma. Avoid sun, exposure to extreme heat or phosphorus insecticides. Surgery: consider lower anesthetic dose. Monitor blood, hepatic, and renal function. Write ℞ for smallest practical amounts. Reevaluate periodically. Debilitated. Elderly. Pregnancy, nursing mothers: not recommended.

Interactions:

Potentiates CNS depression with alcohol, other CNS depressants. Adjust anticonvulsant doses. Additive anticholinergic effects with atropine or related-drugs.

Pharmacological Class:

Piperazinyl phenothiazine.

Adverse Reactions:

Tardive dyskinesia, drowsiness, jaundice, blood dyscrasias, hypotension, ECG changes, retinopathy, may mask emetic signs of disease, lowered seizure threshold, rash, skin pigmentation, anticholinergic effects, insomnia, adynamic ileus, hyperprolactinemia, extrapyramidal reactions, neuroleptic malignant syndrome.

Note:

Formerly known under the brand name Trilafon.

How Supplied:

Contact supplier.

Indications for Perphenazine:

Manifestations of psychotic disorders.

Adult:

Nonhospitalized: initially 4–8mg 3 times daily; then reduce to lowest effective dose. Hospitalized: 8–16mg 2–4 times daily; max 64mg per day.

Children:

Not recommended.

Contraindications:

Coma. Concomitant large doses of CNS depressants. Blood dyscrasias. Bone marrow depression. Liver damage. Subcortical brain damage.

Warnings/Precautions:

CNS depression. Epilepsy. Cardiovascular disease. Respiratory disorders. History of breast cancer. Pheochromocytoma. Avoid sun, exposure to extreme heat or phosphorus insecticides. Surgery: consider lower anesthetic dose. Monitor blood, hepatic, and renal function. Write ℞ for smallest practical amounts. Reevaluate periodically. Debilitated. Elderly. Pregnancy, nursing mothers: not recommended.

Interactions:

Potentiates CNS depression with alcohol, other CNS depressants. Adjust anticonvulsant doses. Additive anticholinergic effects with atropine or related-drugs.

Pharmacological Class:

Piperazinyl phenothiazine.

Adverse Reactions:

Tardive dyskinesia, drowsiness, jaundice, blood dyscrasias, hypotension, ECG changes, retinopathy, may mask emetic signs of disease, lowered seizure threshold, rash, skin pigmentation, anticholinergic effects, insomnia, adynamic ileus, hyperprolactinemia, extrapyramidal reactions, neuroleptic malignant syndrome.

Note:

Formerly known under the brand name Trilafon.

How Supplied:

Contact supplier.

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