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PENTAM 300
Fungal infections
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Drug Name:

PENTAM 300 Rx

Generic Name and Formulations:
Pentamidine isethionate 300mg/vial; lyophilized pwd for IM or IV inj after reconstitution.

Company:
Fresenius Kabi USA

Therapeutic Use:

Indications for PENTAM 300:

Pneumonia due to Pneumocystis carinii.

Adults and Children:

<4months: not recommended. Give by deep IM or IV inj. If administered by IV, must infused over 60–120 minutes. ≥4months: 4mg/kg once daily for 14–21 days. Therapy >21 days has been used; but may increase toxicity risk.

Warnings/Precautions:

Hyper- or hypotension. Ventricular tachycardia. Hypo- or hyperglycemia. Hypocalcemia. Pancreatitis. Leukopenia. Thrombocytopenia. Anemia. Hepatic or renal dysfunction. Stevens-Johnson syndrome. Monitor BP, BUN, serum creatinine, blood glucose, CBC and platelets, liver function (eg, serum bilirubin, alkaline phosphatase, AST/ALT), serum calcium, ECG. Avoid extravasation. Have resuscitation equipment available. Pregnancy (Cat.C; avoid). Nursing mothers: not recommended.

Interactions:

Additive effects with concomitant other nephrotoxic drugs (eg, aminoglycosides, amphotericin B, cisplatin, foscarnet, vancomycin); monitor closely or avoid if possible.

Pharmacological Class:

Aromatic diamidine.

Adverse Reactions:

Inj site reactions, severe hypotension, hypoglycemia, diabetes, acute pancreatitis, cardiac arrhythmias, nephrotoxic events (eg, renal dysfunction, elevated serum creatinine, azotemia, renal failure), leukopenia, elevated liver functions tests, anorexia/nausea, rash, pruritus.

How Supplied:

Single-dose vials—10

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