ADD THIS DRUG TO MY LIST

Select the drug indication to add to your list

PEGASYS
Viral infections
Compare To Related Drugs
View/Edit/Compare Drugs In My List

Only 4 drugs may be compared at once

Drug Name:

PEGASYS Rx

Generic Name and Formulations:
Peginterferon alfa-2a (polyethylene glycol/recombinant alfa interferon conjugate) 180mcg/mL (vials), 180mcg/0.5mL (prefilled syringes and autoinjectors), 135mcg/0.5mL (autoinjectors); soln for SC inj; contains benzyl alcohol.

Company:
Roche Diagnostics Corp.

Therapeutic Use:

Indications for PEGASYS:

As part of a combination regimen, to treat adults with chronic hepatitis C (CHC) with compensated liver disease (monotherapy only indicated if there are contraindications or significant intolerance to other HCV antiviral drugs). In combination with ribavirin for the treatment of pediatric patients ≥5yrs with CHC and compensated liver disease. HBeAg (+) or HBeAg (–) chronic hepatitis B (hep B), in adults with compensated liver disease and evidence of viral replication and liver inflammation.

Limitations Of use:

Pegasys alone or in combination with ribavirin without additional HCV antiviral drugs is not recommended for patients who previously failed therapy with an interferon-alfa. Not recommended for patients with solid organ transplantation.

Adult:

SC inj into thigh or abdomen. If used in combination with other CHC antiviral drugs, refer to labeling of other antivirals for duration of entire treatment regimen. CHC (Genotypes 1, 4): 180mcg once weekly; if Pegasys and ribavirin used without other HCV antivirals, recommended duration is 48 weeks. CHC (Genotypes 2, 3): 180mcg once weekly; if Pegasys and ribavirin used without other HCV antivirals, recommended duration is 24 weeks. Monotherapy: 180mcg once weekly for 48 weeks. CHC with HIV co-infection: 180mcg once weekly; with other HCV antivirals, see labeling for treatment duration; in combination with ribavirin without other HCV antivirals: recommended duration is 48 weeks. Chronic hep B: 180mcg once weekly for 48 weeks. CrCl <30mL/min or ESRD on hemodialysis: 135mcg SC once weekly; may reduce to 90mcg once weekly if severe adverse reactions or lab abnormalities develop; if intolerance persists, discontinue. Reduce dose and/or discontinue if ALT increases progressively or with increased bilirubin, or if neutropenia, thrombocytopenia, or depression occurs (see full labeling).

Children:

<5yrs: not established. ≥5yrs: 180mcg/1.73m2 x BSA SC once weekly; max dose 180mcg; give in combination with ribavirin. HCV genotypes 2 or 3: treat for 24 weeks. Other HCV genotypes: treat for 48 weeks. Patients who initiate treatment before 18th birthday should maintain recommended pediatric dosage.

Contraindications:

Autoimmune hepatitis. Hepatic decompensation (Child-Pugh B and C) in cirrhotic patients or cirrhotic CHC patients coinfected with HIV. Neonates. Infants. Combination with ribavirin contraindicated in pregnancy, men with pregnant partners, and in hemoglobinopathies.

Warnings/Precautions:

May worsen neuropsychiatric, autoimmune, endocrine, ischemic, ophthalmic, pulmonary, or infectious disorders: monitor closely, discontinue if severe or persistently worsens. Cardiovascular or cerebrovascular disease. Renal impairment. Severe myelosuppression. Discontinue if severe hypersensitivity reactions, colitis or pancreatitis develops. Monitor CBC, thyroid, visual, renal, and hepatic function before and during therapy. Transplant recipients. CD4 cell count <100 cells/microliter. HBV with HCV or HIV co-infection. Elderly. Pregnancy (Cat.C); may have abortifacient effects. Nursing mothers: not recommended.

Interactions:

May potentiate theophylline, methadone. Caution with NRTIs; monitor for toxicities. Monitor for worsening neutropenia and/or anemia with zidovudine. Peripheral neuropathy possible with concomitant telbivudine.

Adverse Reactions:

Flu-like symptoms, psychiatric/CNS effects (depression, irritability, suicidal ideation, headache, insomnia), alopecia, GI upset, decreased CD4, CD8 counts; cardiovascular, hepatic, hematologic (eg, decreased WBCs, platelets), respiratory, thyroid, visual abnormalities, infections, anorexia, ALT elevations; possible growth inhibition (w. combination therapy) in pediatrics.

Note:

Note: See Copegus entry in Antivirals section for information on ribavirin.

How Supplied:

Vial single-use—1; Prefilled syringe—4 (w. supplies); Autoinjector—1, 4

Sign Up for Free e-newsletters