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PARLODEL
Parkinsonism
Pituitary disorders
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Drug Name:

PARLODEL Rx

Generic Name and Formulations:
Bromocriptine (as mesylate) 2.5mg; scored tabs.

Company:
Validus Pharmaceuticals

Therapeutic Use:

Indications for PARLODEL:

Parkinsonism.

Adult:

Take with food. Initially 1.25mg twice daily. May increase every 2–4 weeks by 2.5mg/day; max 100mg/day. Maintain levodopa dose at first.

Children:

Not recommended.

Contraindications:

Uncontrolled hypertension. Hypertension of pregnancy. Ergot alkaloid sensitivity. Postpartum women with a history of coronary artery disease and other severe CV conditions.

Warnings/Precautions:

Patients unresponsive to levodopa: poor candidates for bromocriptine therapy. Dementia. MI. Arrhythmias. Renal or hepatic disease. Raynaud's syndrome. Discontinue if hypertension, severe headache, or CNS toxicity occurs. Psychosis. Peptic ulcer. GI bleed. Monitor hepatic, cardiovascular, renal function, BP, blood counts. New or increased gambling urges, sexual urges, uncontrolled spending, others. Melanoma risk increased; perform periodic skin examinations. Pregnancy (Cat.B); discontinue if occurs. Nursing mothers: not recommended.

Interactions:

See Contraindications. Adverse reactions potentiated by alcohol. Potentiated by macrolide antibiotics (eg, erythromycin), octreotide, other strong CYP3A4 inhibitors (eg, azole antimycotics, HIV protease inhibitors). Concomitant ergot alkaloids: not recommended. Caution with dopamine antagonists, butyrophenones, drugs that affect BP. Antagonized by phenothiazines, haloperidol, metoclopramide, pimozide.

See Also:

PARLODEL CAPSULES

Pharmacological Class:

Dopamine agonist (ergot deriv).

Adverse Reactions:

GI upset, involuntary movements, hallucinations, confusion, on-off phenomenon, dizziness, drowsiness, insomnia, syncope, asthenia, visual disturbances, ataxia, hypotension; rarely: hypertension, seizure, stroke, MI.

How Supplied:

Tabs, caps—30, 100

Indications for PARLODEL:

Hyperprolactinemia-associated amenorrhea, galactorrhea, infertility, hypogonadism. Prolactin-secreting adenomas. Acromegaly.

Adult:

Take with food. Hyperprolactinemia: initially 1.25–2.5mg/day, may increase every 2–7 days by 2.5mg/day; range 2.5–15mg/day. Acromegaly: 1.25–2.5mg at bedtime for 3 days then increase by 1.25–2.5mg/day every 3–7 days; range 20–30mg/day; max 100mg/day.

Children:

<11 years: not recommended. 11–15 years: initially 1.25mg–2.5mg daily; range 2.5–10mg/day.

Contraindications:

Uncontrolled hypertension. Ergot alkaloid sensitivity. Pregnancy (in patients being treated for hyperprolactinemia). Hypertension of pregnancy. Postpartum women with a history of coronary artery disease and other severe CV conditions.

Warnings/Precautions:

Evaluate pituitary first. Use barrier contraception until ovulation normalizes; monitor for pregnancy. Dementia. MI. Arrhythmias. Cardiovascular, renal, or hepatic disease. Raynaud's syndrome. Discontinue if hypertension, severe headache, or CNS toxicity occurs. Psychosis. Peptic ulcer. GI bleed. Monitor BP. Pregnancy (Cat.B); discontinue if occurs. Nursing mothers: not recommended.

Interactions:

See Contraindications. Adverse reactions potentiated by alcohol. Potentiated by macrolide antibiotics (eg, erythromycin), octreotide, other strong CYP3A4 inhibitors (eg, azole antimycotics, HIV protease inhibitors). Concomitant ergot alkaloids: not recommended. Caution with dopamine antagonists, butyrophenones, drugs that affect BP. Antagonized by phenothiazines, haloperidol, metoclopramide, pimozide.

See Also:

PARLODEL CAPSULES

Pharmacological Class:

Dopamine agonist (ergot deriv).

Adverse Reactions:

GI upset, headache, dizziness, fatigue, abdominal cramps, drowsiness, hypotension, syncope, rarely: hypertension, seizures, stroke, MI. Acromegaly: also digital vasospasm, GI bleed.

How Supplied:

Tabs, caps—30, 100

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