Parkinson’s Disease Archive
Declining smoking rates could be associated with higher incidence of parkinsonism and PD.
The drug is the first of its kind to address PD psychosis without having an ill effect on motor symptoms.
Declines in processing sleep and episodic memory were observed in those with low levels of activity.
The researchers observed between-group differences between real and sham acupuncture treatment.
Unclear whether the medications or the disease are the key factor; study only shows an association.
Research found an association, but no cause-and-effect relationship, between rosacea and Parkinson's.
Those with cognitive difficulties struggle to follow conversations or recall words.
Study reports on the availability of safety and efficacy data for over-the-counter supplements for improving brain health.
Of adults aged 45 years and older reporting recent check-up, only 25.2% reported SMCs.
However, results should be interpreted with attention to the study details, Mayo doc says.
Men with higher urate concentrations had a lower future risk of developing Parkinson's, suggesting that urate could have a protective factor.
Those who took rivastigmine in study were 45% less likely to have an accident.
Results from a recent multiple sclerosis trial with simvastatin indicate that it could be an effective treatment to slow progression of Parkinson's.
There was no difference in cognition between Parkinson's patients taking a high and lower level of anticholinergic medications.
Research has shown a confounding link between nicotine and reduced risk of Parkinson's disease.
Patients with hepatitis C were 2.5 times more likely to develop Parkinson's before adjustments.
In a mouse model of Parkinson's, LBT-3727 was able to protect dopamine-producing cells.
After performing brain autopsies, researchers found pesticide residue in 90% of the participants.
Based on visual responses of fruit flies, the ones with mutations toward Parkinson's had increase neuronal activity to stimulation.
Researchers identified two genes with potentially damaging genetic variants that could affect familial Parkinson's susceptibility.
Studies in mice, monkeys point to a compound that might lessen levodopa's debilitating effects, such as restless muscle movements.
The new criteria emphasizes that Parkinson's is more than a motor disorder, emphasizing the early stages of the disease.
Inconsistent conclusion among studies looking at the association may be the result of retrospective assessments, definition of drinkers.
The researchers observed significant increases in gait speed, step length, floor reaction force, and cadence after acupuncture.
Scientists may have discovered a way to stop the formation of Lewy bodies, protein clumps found in the brains of those with Parkinson's.
Nilotinib (Tasigna) improved cognition and motor skills in patients with Parkinson's and Lewy body dementia.
The test uses autoantibodies as blood-based biomarkers to detect not only the presence of Alzheimer's, but how far along the disease has progressed.
PDP patients treated with antipsychotics were four times as likely to died following three to six months of treatment than those not on the meds.
A non-threatening virus was delivered a genetic "switch" to cholinergic neurons in the brains of rat cells, followed by a drug to activate the "switch."
Parkinson's disease patients who received transcranial direct current stimulation saw a 25% improvement in motor symptoms.
Over 60% of people with Parkinson's disease will have REM sleep behavior disorder, endangering them and their partners during the night.
Highest risk of subsequent Parkinson's was with asthma patients with more frequent hospital admissions.
Discovery could potentially lead to new treatments.
In people with PD, high neurofilament light chain protein, low Aβ1-42, and high heart fatty acid-binding protein was associate with PD dementia.
Patients who used glitazones were 28% less likely to be diagnosed with Parkinson's than those who never took one of the medications.
Monoclonal antibodies targeting tau and amyloid beta in Alzheimer's disease may benefit other neurodegenerative diseases.
Rats with Parkinson's symptoms given chloroquine and amodiaquine, two popular antimalaria drugs, showed improvements in movement.
Researchers find narcolepsy symptoms the most severe in patients taking dopamine agonists, so clinicians should be cautious in using them.
The antidepressant citalopram and the Parkinson's med levodopa influenced how much pain people were willing to inflict on themselves or others.
Improved communication and information between Parkinson's researchers and patients could lead to greater success in Parkinson's clinical trials.
Pseudobulbar affect, which involves uncontrollable emotional outbursts, has been reported in diseases including Alzheimer's and Parkinson's.
Parkinson's patients who took any antipsychotic were more than twice as likely to die within 180 days than those not on one.
Juice from a variety of New Zealand blackcurrants led to improvements in mood, attention and mental fatigue in patients.
Apomorphine that is injected was shown to work faster than oral levodopa to treat morning akinesia in Parkinson's disease patients.
Parkinson's disease patients who were given the inhaled levodopa showed rapid improvement in motor symptoms and a reduction in "off" hours daily.
Antipsychotics have been effective in the treatment of psychotic disorders, but clinicians must be cognizant of side effects.
PD psychosis is underreported and faces treatment challenges, though a new treatment on the horizon may change that.
Taiwanese study shows that Parkinson's disease was associated with a higher risk of 16 types of cancer, including lung and brain tumors.
The Brio Neurostimulation System continuously delivers low-intensity electrical pulses to the brain to treat Parkinson's and essential tremor.
Opicapone, a COMT inhibitor added to levodopa, reduced absolute off-time by two hours compared to placebo in Parkinson's patients.
More than one-third of early Parkinson's patients, whether or not taking medication, reported severe fatigue, memory difficulties and urinary urgency.
Patients with mild-to-moderate Alzheimer's and Parkinson's tended to experience more pain, yet those with other forms of cognitive impairment had less.
MRI imaging indicates that in Parkinson's patients, the brain's substania nigra changes as the disease progresses.
Only 1.1% of those with depression eventually developed Parkinson's, compared with 0.4% without a history of depression.
However, the blood pressure medication candesartan and an experimental drug both reduced the immune response.
The Movement Disorders Journal app can document slowness, tremor, and gait/balance and export data to clinicians.
The Oculus Rift headset, normally used to provide a 3D gaming experience, lets clinicians experience hallucinations and delusions.
Patients who were switched from oral carbidopa-levodopa to CLES (Duopa) showed improvements in motor system functioning.
Parkinson's patients who learned the Argentine tango saw improvement in balance and functional mobility.
RNA signatures identified that correlate with mutations in the LRRK2 gene, a known risk factor for Parkinson's.
MIT researchers say an algorithm they've created that analyzes keystrokes can detect motor skills impairment, and potentially, Parkinson's.
The ARC pen can improve the handwriting of people with Parkinson's disease suffering from micrographia.
People who drank a lot of milk had higher levels of the antioxidant glutathione, which is known to have protective properties for the brain.
Korean study, however, finds that patients developed new pain in muscles and joints eight years after receiving treatment.
Parkinson mPower can measure a patient's dexterity, balance and gait multiple times daily and then share that information with researchers.
Device provides pulses through patches attached to the head behind the ears, stimulating the vestibular system.
People with gout have a 24% lower risk of developing Alzheimer's disease.
If approved, Xadago would be an add-on therapy in both early and mid-to-late stage Parkinson's.
Peptide works by stopping formation of faulty proteins that kill brain cells that produce dopamine.
Skin biopsies can reveal high levels of abnormal proteins linked to Alzheimer's and Parkinson's.
While having high cholesterol may lower the risk for Parkinson's, taking a statin medication may actually increase the risk.
Patients given platelet-derived growth factor had increased levels of dopamine signaling compared to those on placebo.
Volatile organic compounds emitted in exhaled breath are different in those with Parkinson's.
Prior research in mice indicated creatine might protect nerve cells.
In small study, some patients that received electrical stimulation to the brain saw the size of their brains increase.
Researchers find two genetic markets that are 90% effective at indicating the presence of Parkinson's disease.
A compound in the hops of beer may protect brain cells from damage that causes neurodegenerative diseases.
Parkinson's patients told they were being given new, expensive medication that in reality was a fake pill reported improvements in movement symptoms.
Duopa, a combination of carbidopa and levodopa, will be available on a rolling basis over the coming months.
Rytary is meant to reduce "on" and "off" periods of Parkinson's symptoms.
NeuroDerm's ND0612H, a drug-device combination product, provided consistent delivery of levodopa and carbidopa throughout the day in a mid-stage study.
Exercise resulted in fewer falls only in patients with lower severity of Parkinson's disease.
If approved, safinamide would be an add-on therapy to either a dopamine agonist, levodopa, or other Parkinson's treatments.
Risk even higher among female methamphetamine users compared with nonusers.
Despite FDA concerns, non-ergot derived dopamine agonists, such as ramipexole and ropinirole, do not lead to increase heart failure risk.
People who got at least six hours a week of light physical activity had a 43% lower risk of Parkinson's than those who get less than two hours.
Placebo effect appears to activate dopamine-rich parts of the brain in patients with Parkinson's, improving learning-related brain activity.
Weight gain due to deep brain stimulation and weight loss from depression or changes to senses common in Parkinson's patients.
People with Parkinson's disease that exercised for at least 150 minutes per week showed improvements in quality of life and less cognitive decline.
Case study finds extrapyramidal symptoms in man with Parkinsonism went away after IV infusion of zinc and vitamin C.
Dopamine cells created from stem cells that were implanted into the brains of rats reversed brain damage.
In a study, mice given high-fat diets were able to slow down aging process in cells.
Dopamine receptor agonists were linked to adverse events such as compulsive gambling and shopping.
In mice, the drug, AT2101, stopped brain inflammation and improved motor function.
Patients with Parkinson's disease that had a certain genotype for the APOE gene had worse score on cognition tests compared to thsoe without the variant.
No increase in post-implant surgery complication in Parkinson's patients older than 75 years compared to younger patients.
Punicalagin, a compound found in pomegranates, led to the inhibition of inflammation in brain cells from mice.
Untreated Parkinson's patients in the early stages of the disease are more likely to experience neuropsychiatric symptoms.
A letter of the editor questions whether the results of genetic testing in clinical trials should be transparent to the study participants, particularly with Parkinsonism.
PARC/CUL9 protein prolongs neuron survival allowing brain to function normally over time.
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