Parkinson’s Disease Archive

Physical Activity Level Affects Rate of Cognitive Decline

Physical Activity Level Affects Rate of Cognitive Decline

Declines in processing sleep and episodic memory were observed in those with low levels of activity.

Possibly From Placebo Effect, Acupuncture Improves Fatigue in Parkinson's

Possibly From Placebo Effect, Acupuncture Improves Fatigue in Parkinson's

The researchers observed between-group differences between real and sham acupuncture treatment.

Antipsychotics May Boost Early Death Risk in Parkinson's

Antipsychotics May Boost Early Death Risk in Parkinson's

Unclear whether the medications or the disease are the key factor; study only shows an association.

Rosacea May Increase Risk of Parkinson's

Rosacea May Increase Risk of Parkinson's

Research found an association, but no cause-and-effect relationship, between rosacea and Parkinson's.

Cognitive Decline Has Greater Impact on Speech in Parkinson's

Cognitive Decline Has Greater Impact on Speech in Parkinson's

Those with cognitive difficulties struggle to follow conversations or recall words.

Memory-Enhancing Supplements: What's the Evidence?

Memory-Enhancing Supplements: What's the Evidence?

Study reports on the availability of safety and efficacy data for over-the-counter supplements for improving brain health.

Subjective Memory Complaints Rarely Discussed With Docs

Subjective Memory Complaints Rarely Discussed With Docs

Of adults aged 45 years and older reporting recent check-up, only 25.2% reported SMCs.

Physical Therapy May Not Help Parkinson's Patients

Physical Therapy May Not Help Parkinson's Patients

However, results should be interpreted with attention to the study details, Mayo doc says.

Lower Risk of Parkinson's In Men With Higher Uric Acid Concentration

Lower Risk of Parkinson's In Men With Higher Uric Acid Concentration

Men with higher urate concentrations had a lower future risk of developing Parkinson's, suggesting that urate could have a protective factor.

Dementia Med Lowers Risk of Falls in Parkinson's Patients

Dementia Med Lowers Risk of Falls in Parkinson's Patients

Those who took rivastigmine in study were 45% less likely to have an accident.

Could Cholesterol-Lowering Drug Simvastatin Treat Parkinson's?

Could Cholesterol-Lowering Drug Simvastatin Treat Parkinson's?

Results from a recent multiple sclerosis trial with simvastatin indicate that it could be an effective treatment to slow progression of Parkinson's.

Anticholinergic Drugs Not Harmful to Parkinson's Patients

Anticholinergic Drugs Not Harmful to Parkinson's Patients

There was no difference in cognition between Parkinson's patients taking a high and lower level of anticholinergic medications.

Parkinson's and Smoking: A Neuroprotective Role for Nicotine?

Parkinson's and Smoking: A Neuroprotective Role for Nicotine?

Research has shown a confounding link between nicotine and reduced risk of Parkinson's disease.

Hepatitis C a Possible Risk Factor for Parkinson's Disease

Hepatitis C a Possible Risk Factor for Parkinson's Disease

Patients with hepatitis C were 2.5 times more likely to develop Parkinson's before adjustments.

Drug That Protects Dopamine Cells Eyed as Parkinson's Treatment

Drug That Protects Dopamine Cells Eyed as Parkinson's Treatment

In a mouse model of Parkinson's, LBT-3727 was able to protect dopamine-producing cells.

Pesticide-Contaminated Milk May Be Linked to Parkinson's Disease

Pesticide-Contaminated Milk May Be Linked to Parkinson's Disease

After performing brain autopsies, researchers found pesticide residue in 90% of the participants.

Visual Response Test Could Be Biomarker for Early Parkinson's

Visual Response Test Could Be Biomarker for Early Parkinson's

Based on visual responses of fruit flies, the ones with mutations toward Parkinson's had increase neuronal activity to stimulation.

Rare Genetic Variants Linked to Familial Parkinson's Disease Risk

Rare Genetic Variants Linked to Familial Parkinson's Disease Risk

Researchers identified two genes with potentially damaging genetic variants that could affect familial Parkinson's susceptibility.

New Compound May Reduce Parkinson Drug's Adverse Effects

New Compound May Reduce Parkinson Drug's Adverse Effects

Studies in mice, monkeys point to a compound that might lessen levodopa's debilitating effects, such as restless muscle movements.

New Criteria Developed to Better Diagnose, Treat Parkinson's

New Criteria Developed to Better Diagnose, Treat Parkinson's

The new criteria emphasizes that Parkinson's is more than a motor disorder, emphasizing the early stages of the disease.

No Conclusive Link Between Alcohol Consumption and Parkinson's

No Conclusive Link Between Alcohol Consumption and Parkinson's

Inconsistent conclusion among studies looking at the association may be the result of retrospective assessments, definition of drinkers.

Acupuncture Improves Walking in Parkinson's Patients

Acupuncture Improves Walking in Parkinson's Patients

The researchers observed significant increases in gait speed, step length, floor reaction force, and cadence after acupuncture.

Mechanism to Stop Lewy Body Formation Has Parkinson's Treatment Promise

Mechanism to Stop Lewy Body Formation Has Parkinson's Treatment Promise

Scientists may have discovered a way to stop the formation of Lewy bodies, protein clumps found in the brains of those with Parkinson's.

Cancer Drug Improves Parkinson's Symptoms and Progression

Cancer Drug Improves Parkinson's Symptoms and Progression

Nilotinib (Tasigna) improved cognition and motor skills in patients with Parkinson's and Lewy body dementia.

Early Alzheimer's Detection Possible With New Blood Test

Early Alzheimer's Detection Possible With New Blood Test

The test uses autoantibodies as blood-based biomarkers to detect not only the presence of Alzheimer's, but how far along the disease has progressed.

Treating Parkinson's Psychosis With Antipsychotics May Boost Death Risk

Treating Parkinson's Psychosis With Antipsychotics May Boost Death Risk

PDP patients treated with antipsychotics were four times as likely to died following three to six months of treatment than those not on the meds.

Noninvasive Way to Target Brain Cells Impacted by Parkinson's Found

Noninvasive Way to Target Brain Cells Impacted by Parkinson's Found

A non-threatening virus was delivered a genetic "switch" to cholinergic neurons in the brains of rat cells, followed by a drug to activate the "switch."

Brain Stimulation Can Improve Motor Function in Parkinson's

Brain Stimulation Can Improve Motor Function in Parkinson's

Parkinson's disease patients who received transcranial direct current stimulation saw a 25% improvement in motor symptoms.

Treating Sleep Disorders in Parkinson's Disease Patients

Treating Sleep Disorders in Parkinson's Disease Patients

Over 60% of people with Parkinson's disease will have REM sleep behavior disorder, endangering them and their partners during the night.

Asthma May Increase Risk of Developing Parkinson's

Asthma May Increase Risk of Developing Parkinson's

Highest risk of subsequent Parkinson's was with asthma patients with more frequent hospital admissions.

'Brain Cell Burnout' May Be at Root of Parkinson's

'Brain Cell Burnout' May Be at Root of Parkinson's

Discovery could potentially lead to new treatments.

Biomarkers May Predict Dementia in Parkinson's Disease

Biomarkers May Predict Dementia in Parkinson's Disease

In people with PD, high neurofilament light chain protein, low Aβ1-42, and high heart fatty acid-binding protein was associate with PD dementia.

Common Diabetes Drugs May Reduce Risk of Parkinson's

Common Diabetes Drugs May Reduce Risk of Parkinson's

Patients who used glitazones were 28% less likely to be diagnosed with Parkinson's than those who never took one of the medications.

Antibodies Targeting Alzheimer's May Benefit Other Neurological Diseases

Antibodies Targeting Alzheimer's May Benefit Other Neurological Diseases

Monoclonal antibodies targeting tau and amyloid beta in Alzheimer's disease may benefit other neurodegenerative diseases.

Malaria Drugs Examined As Potential Parkinson's Treatment

Malaria Drugs Examined As Potential Parkinson's Treatment

Rats with Parkinson's symptoms given chloroquine and amodiaquine, two popular antimalaria drugs, showed improvements in movement.

Excessive Sleepiness Worsens in Parkinson's As Disease Progresses

Excessive Sleepiness Worsens in Parkinson's As Disease Progresses

Researchers find narcolepsy symptoms the most severe in patients taking dopamine agonists, so clinicians should be cautious in using them.

Antidepressants, Parkinson's Med May Affect Morality, Decision-Making

Antidepressants, Parkinson's Med May Affect Morality, Decision-Making

The antidepressant citalopram and the Parkinson's med levodopa influenced how much pain people were willing to inflict on themselves or others.

Inadequate Funding, Patient Fear Hinder Parkinson's Research

Inadequate Funding, Patient Fear Hinder Parkinson's Research

Improved communication and information between Parkinson's researchers and patients could lead to greater success in Parkinson's clinical trials.

Uncontrollable Crying or Laughing: What's Behind Pseudobulbar Affect?

Uncontrollable Crying or Laughing: What's Behind Pseudobulbar Affect?

Pseudobulbar affect, which involves uncontrollable emotional outbursts, has been reported in diseases including Alzheimer's and Parkinson's.

Mortality Risk Increased for Parkinson's Patients on Antipsychotics

Mortality Risk Increased for Parkinson's Patients on Antipsychotics

Parkinson's patients who took any antipsychotic were more than twice as likely to die within 180 days than those not on one.

Blackcurrant Juice Could Reduce Depression, Parkinson's Symptoms

Blackcurrant Juice Could Reduce Depression, Parkinson's Symptoms

Juice from a variety of New Zealand blackcurrants led to improvements in mood, attention and mental fatigue in patients.

Apomorphine Injection Rapidly Improves Morning Akinesia in Parkinson's

Apomorphine Injection Rapidly Improves Morning Akinesia in Parkinson's

Apomorphine that is injected was shown to work faster than oral levodopa to treat morning akinesia in Parkinson's disease patients.

Inhaled Levodopa Rapidly Enhances Motor Function in Parkinson's

Inhaled Levodopa Rapidly Enhances Motor Function in Parkinson's

Parkinson's disease patients who were given the inhaled levodopa showed rapid improvement in motor symptoms and a reduction in "off" hours daily.

An Overview of Psychotic Disorders and Treatment

An Overview of Psychotic Disorders and Treatment

Antipsychotics have been effective in the treatment of psychotic disorders, but clinicians must be cognizant of side effects.

Parkinson's Disease Psychosis: Common, Yet Not Often Reported

Parkinson's Disease Psychosis: Common, Yet Not Often Reported

PD psychosis is underreported and faces treatment challenges, though a new treatment on the horizon may change that.

Parkinson's Disease Associated With Higher Risk of Many Cancer Types

Parkinson's Disease Associated With Higher Risk of Many Cancer Types

Taiwanese study shows that Parkinson's disease was associated with a higher risk of 16 types of cancer, including lung and brain tumors.

Parkinson's Brain Stimulation Device Gains FDA Approval

Parkinson's Brain Stimulation Device Gains FDA Approval

The Brio Neurostimulation System continuously delivers low-intensity electrical pulses to the brain to treat Parkinson's and essential tremor.

Novel Parkinson's Drug Dosed Once Daily Significantly Reduces Off-Time

Novel Parkinson's Drug Dosed Once Daily Significantly Reduces Off-Time

Opicapone, a COMT inhibitor added to levodopa, reduced absolute off-time by two hours compared to placebo in Parkinson's patients.

Severe Nonmotor Symptoms Found in Many Early Parkinson's Patients

Severe Nonmotor Symptoms Found in Many Early Parkinson's Patients

More than one-third of early Parkinson's patients, whether or not taking medication, reported severe fatigue, memory difficulties and urinary urgency.

Some Alzheimer's Patients Have Increased Pain Sensitivity

Some Alzheimer's Patients Have Increased Pain Sensitivity

Patients with mild-to-moderate Alzheimer's and Parkinson's tended to experience more pain, yet those with other forms of cognitive impairment had less.

New Parkinson's Biomarker Identified Through Changes in Brain Area

New Parkinson's Biomarker Identified Through Changes in Brain Area

MRI imaging indicates that in Parkinson's patients, the brain's substania nigra changes as the disease progresses.

History of Depression May Raise Parkinson's Risk

History of Depression May Raise Parkinson's Risk

Only 1.1% of those with depression eventually developed Parkinson's, compared with 0.4% without a history of depression.

Parkinson's Protein May Trigger Brain Inflammation

Parkinson's Protein May Trigger Brain Inflammation

However, the blood pressure medication candesartan and an experimental drug both reduced the immune response.

Diary App Can Help Parkinson's Patients Track Symptoms

Diary App Can Help Parkinson's Patients Track Symptoms

The Movement Disorders Journal app can document slowness, tremor, and gait/balance and export data to clinicians.

Virtual Reality Gives Clinicians Window into Parkinson's Psychosis

Virtual Reality Gives Clinicians Window into Parkinson's Psychosis

The Oculus Rift headset, normally used to provide a 3D gaming experience, lets clinicians experience hallucinations and delusions.

Carbidopa-Levodopa Gel Can Better Manage Parkinson's Symptoms

Carbidopa-Levodopa Gel Can Better Manage Parkinson's Symptoms

Patients who were switched from oral carbidopa-levodopa to CLES (Duopa) showed improvements in motor system functioning.

Dancing May Improve Some Parkinson's Symptoms

Dancing May Improve Some Parkinson's Symptoms

Parkinson's patients who learned the Argentine tango saw improvement in balance and functional mobility.

Blood Test May Identify New Biomarkers for Parkinson's

Blood Test May Identify New Biomarkers for Parkinson's

RNA signatures identified that correlate with mutations in the LRRK2 gene, a known risk factor for Parkinson's.

Could Analyzing Typing Patterns Help Diagnose Parkinson's Disease?

Could Analyzing Typing Patterns Help Diagnose Parkinson's Disease?

MIT researchers say an algorithm they've created that analyzes keystrokes can detect motor skills impairment, and potentially, Parkinson's.

Special Pen Improves Handwriting in Parkinson's Patients

Special Pen Improves Handwriting in Parkinson's Patients

The ARC pen can improve the handwriting of people with Parkinson's disease suffering from micrographia.

Can Milk Improve Brain Health and Prevent Alzheimer's?

Can Milk Improve Brain Health and Prevent Alzheimer's?

People who drank a lot of milk had higher levels of the antioxidant glutathione, which is known to have protective properties for the brain.

Deep Brain Stimulation May Bring Long-Term Parkinson's Pain Relief

Deep Brain Stimulation May Bring Long-Term Parkinson's Pain Relief

Korean study, however, finds that patients developed new pain in muscles and joints eight years after receiving treatment.

App Allows Parkinson's Patients To Share Symptom Data with Researchers

App Allows Parkinson's Patients To Share Symptom Data with Researchers

Parkinson mPower can measure a patient's dexterity, balance and gait multiple times daily and then share that information with researchers.

Electric 'Noise' Device Could Improve Balance in Parkinson's Patients

Electric 'Noise' Device Could Improve Balance in Parkinson's Patients

Device provides pulses through patches attached to the head behind the ears, stimulating the vestibular system.

Gout May Lower Risk for Developing Alzheimer's Disease

Gout May Lower Risk for Developing Alzheimer's Disease

People with gout have a 24% lower risk of developing Alzheimer's disease.

NDA for New Parkinson's Drug Accepted by the FDA

NDA for New Parkinson's Drug Accepted by the FDA

If approved, Xadago would be an add-on therapy in both early and mid-to-late stage Parkinson's.

Peptide Developed Could Slow Progression of Parkinson's

Peptide Developed Could Slow Progression of Parkinson's

Peptide works by stopping formation of faulty proteins that kill brain cells that produce dopamine.

Skin Test Could Help Diagnose Alzheimer's, Parkinson's

Skin Test Could Help Diagnose Alzheimer's, Parkinson's

Skin biopsies can reveal high levels of abnormal proteins linked to Alzheimer's and Parkinson's.

Benefit of Statins to Lower Parkinson's Risk Questioned

Benefit of Statins to Lower Parkinson's Risk Questioned

While having high cholesterol may lower the risk for Parkinson's, taking a statin medication may actually increase the risk.

Growth Factor May Promote Regeneration in Parkinson's Brains

Growth Factor May Promote Regeneration in Parkinson's Brains

Patients given platelet-derived growth factor had increased levels of dopamine signaling compared to those on placebo.

Breath Test Could Help Diagnose Parkinson's Disease

Breath Test Could Help Diagnose Parkinson's Disease

Volatile organic compounds emitted in exhaled breath are different in those with Parkinson's.

Creatine Shows No Benefit As Parkinson's Treatment

Creatine Shows No Benefit As Parkinson's Treatment

Prior research in mice indicated creatine might protect nerve cells.

Deep Brain Stimulation Shows Promise As Alzheimer's Treatment

Deep Brain Stimulation Shows Promise As Alzheimer's Treatment

In small study, some patients that received electrical stimulation to the brain saw the size of their brains increase.

Blood Test Developed to Detect Parkinson's Early

Blood Test Developed to Detect Parkinson's Early

Researchers find two genetic markets that are 90% effective at indicating the presence of Parkinson's disease.

Beer Ingredient May Slow Alzheimer's, Parkinson's Development

Beer Ingredient May Slow Alzheimer's, Parkinson's Development

A compound in the hops of beer may protect brain cells from damage that causes neurodegenerative diseases.

Strong Placebo Effect Seen With Expensive Parkinson's 'Drugs'

Strong Placebo Effect Seen With Expensive Parkinson's 'Drugs'

Parkinson's patients told they were being given new, expensive medication that in reality was a fake pill reported improvements in movement symptoms.

FDA Approves Long-Acting, Infusion Parkinson's Treatment

FDA Approves Long-Acting, Infusion Parkinson's Treatment

Duopa, a combination of carbidopa and levodopa, will be available on a rolling basis over the coming months.

FDA Approves New Extended-Release Parkinson's Drug

FDA Approves New Extended-Release Parkinson's Drug

Rytary is meant to reduce "on" and "off" periods of Parkinson's symptoms.

Drug-Device Combo Could Help Parkinson's Patients

Drug-Device Combo Could Help Parkinson's Patients

NeuroDerm's ND0612H, a drug-device combination product, provided consistent delivery of levodopa and carbidopa throughout the day in a mid-stage study.

Exercise May Help Reduce Fall Risk in Mild Parkinson's Disease

Exercise May Help Reduce Fall Risk in Mild Parkinson's Disease

Exercise resulted in fewer falls only in patients with lower severity of Parkinson's disease.

NDA Resubmitted to FDA for New Parkinson's Disease Drug

NDA Resubmitted to FDA for New Parkinson's Disease Drug

If approved, safinamide would be an add-on therapy to either a dopamine agonist, levodopa, or other Parkinson's treatments.

Parkinson's Risk Threefold Higher with Meth Use

Parkinson's Risk Threefold Higher with Meth Use

Risk even higher among female methamphetamine users compared with nonusers.

Parkinson's Meds Found Safe for the Heart

Parkinson's Meds Found Safe for the Heart

Despite FDA concerns, non-ergot derived dopamine agonists, such as ramipexole and ropinirole, do not lead to increase heart failure risk.

Regular Physical Activity May Reduce Risk of Parkinson's Disease

Regular Physical Activity May Reduce Risk of Parkinson's Disease

People who got at least six hours a week of light physical activity had a 43% lower risk of Parkinson's than those who get less than two hours.

Placebo Improves Brain Activity in Parkinson's Patients

Placebo Improves Brain Activity in Parkinson's Patients

Placebo effect appears to activate dopamine-rich parts of the brain in patients with Parkinson's, improving learning-related brain activity.

Weight Fluctuations Normal in Patients With Parkinson's Disease

Weight Fluctuations Normal in Patients With Parkinson's Disease

Weight gain due to deep brain stimulation and weight loss from depression or changes to senses common in Parkinson's patients.

Exercise Reduces Cognitive Decline in Patients With Parkinson's

Exercise Reduces Cognitive Decline in Patients With Parkinson's

People with Parkinson's disease that exercised for at least 150 minutes per week showed improvements in quality of life and less cognitive decline.

Zinc, Vitamin C May Help Parkinsonism Symptoms

Zinc, Vitamin C May Help Parkinsonism Symptoms

Case study finds extrapyramidal symptoms in man with Parkinsonism went away after IV infusion of zinc and vitamin C.

Stem Cell Transplants May Heal Brain Damage Caused By Parkinson's

Stem Cell Transplants May Heal Brain Damage Caused By Parkinson's

Dopamine cells created from stem cells that were implanted into the brains of rats reversed brain damage.

High-Fat Diets May Slow Brain Aging

High-Fat Diets May Slow Brain Aging

In a study, mice given high-fat diets were able to slow down aging process in cells.

Parkinson's Meds May Raise Impulsive Behavior Risk

Parkinson's Meds May Raise Impulsive Behavior Risk

Dopamine receptor agonists were linked to adverse events such as compulsive gambling and shopping.

Drug for Rare Disorder Shows Promise for Parkinson's

Drug for Rare Disorder Shows Promise for Parkinson's

In mice, the drug, AT2101, stopped brain inflammation and improved motor function.

Genetic Variant Accelerates Cognitive Decline in Parkinson's

Genetic Variant Accelerates Cognitive Decline in Parkinson's

Patients with Parkinson's disease that had a certain genotype for the APOE gene had worse score on cognition tests compared to thsoe without the variant.

Deep Brain Stimulation Safe for Elderly Parkinson's Patients

Deep Brain Stimulation Safe for Elderly Parkinson's Patients

No increase in post-implant surgery complication in Parkinson's patients older than 75 years compared to younger patients.

Pomegranates Could Play Role in New Alzheimer's Therapies

Pomegranates Could Play Role in New Alzheimer's Therapies

Punicalagin, a compound found in pomegranates, led to the inhibition of inflammation in brain cells from mice.

Depression, Psychosis Risk Greater in Early Parkinson's Disease

Depression, Psychosis Risk Greater in Early Parkinson's Disease

Untreated Parkinson's patients in the early stages of the disease are more likely to experience neuropsychiatric symptoms.

Should Parkinson's Gene Test Results Be Available to Study Participants?

Should Parkinson's Gene Test Results Be Available to Study Participants?

A letter of the editor questions whether the results of genetic testing in clinical trials should be transparent to the study participants, particularly with Parkinsonism.

Protein That Helps Neurons Beat Death Holds Promise for Parkinson's

Protein That Helps Neurons Beat Death Holds Promise for Parkinson's

PARC/CUL9 protein prolongs neuron survival allowing brain to function normally over time.

Protein Panel Predicts Dementia...or Doesn't It?

Protein Panel Predicts Dementia...or Doesn't It?

A study published in Alzheimer's and Dementia that claimed a protein panel forecast dementia may be flawed.

Few with Parkinson's Seek Mental Health Treatment

Few with Parkinson's Seek Mental Health Treatment

Only 8% of patients with Parkinson's disease in study sought treatment for concomitant mental health issue.

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