Opioid-Related Disorder

Abuse-Deterrent Opioid Formulations: Barriers to Broader Use

Abuse-Deterrent Opioid Formulations: Barriers to Broader Use

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Abuse-deterrent opioid formulations have not yet been widely accepted despite their proposed value in reducing opioid abuse and related mortality. Many of the current barriers to broader use are related to their higher cost compared with conventional formulations.

Outpatient Opioid Prescriptions for Children Often Filled

Outpatient Opioid Prescriptions for Children Often Filled

Children often fill outpatient opioid prescriptions, with the most common indication for dental procedures.

Drug treatment associated with a significant reduction in death risk following opioid overdose

Buprenorphine and methadone maintenance treatment was associated with reduced death in opioid users. No significant associations were found between naltrexone and all-cause mortality or opioid-related mortality.

US Surgeon General Urges More Americans to Carry Naloxone

US Surgeon General Urges More Americans to Carry Naloxone

The US Surgeon General released an advisory urging increased availability of the opioid overdose-reversing drug naloxone earlier this year.

NIH Initiative Aims to Address Opioid Misuse Over Long Term

NIH Initiative Aims to Address Opioid Misuse Over Long Term

A novel, innovative initiative is being developed to help end addiction over the long term.

Rate of Death Up in Year After Nonfatal Opioid Overdose

Rate of Death Up in Year After Nonfatal Opioid Overdose

There is a marked excess of deaths among US adults who experience a nonfatal opioid overdose.

Storage and Disposal Information on Opioid Package Inserts Insufficient

Storage and Disposal Information on Opioid Package Inserts Insufficient

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Oxycodone and morphine are more likely to contain messaging on package inserts describing safe storage and disposal methods compared with other commonly used and misused opioid analgesics.

Physicians should look for misuse patterns that lead to overdose before prescribing opioids

Patterns associated with opioid overdose include overlapping prescriptions, use of more than one prescriber or pharmacy, and use of out-of-state prescribers or pharmacies.

Factors Identified for Persistent Opioid Use After Pediatric Surgery

Factors Identified for Persistent Opioid Use After Pediatric Surgery

Higher daily average inpatient pain scores and higher postoperative opioid consumption are associated with a subsequent persistent opioid use.

Illicit Opioid Trade Up With Restrictions on Hydrocodone

Illicit Opioid Trade Up With Restrictions on Hydrocodone

The US Drug Enforcement Administration's 2014 ruling to reschedule hydrocodone combination products coincided with an increase in illicit trading of opioids through online illicit markets.

Wearable Device Cleared for Use During Opioid Detoxification

Wearable Device Cleared for Use During Opioid Detoxification

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Electrical pulses are sent through small needles that are inserted in the ear to combat the early stages of detoxification, leading to stabilization.

FDA Warns Websites Marketing Unapproved Opioids

FDA Warns Websites Marketing Unapproved Opioids

Nine online networks, operating 53 websites, have been warned that they must stop illegally marketing potentially dangerous versions of opioid medications.

Association Between Industry Payments and Opioid Prescribing

Association Between Industry Payments and Opioid Prescribing

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Non-research industry payments to physicians may be associated with increases in opioid prescribing rates.

FDA Issues Warning to Companies Selling Kratom-Containing Products

FDA Issues Warning to Companies Selling Kratom-Containing Products

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The US Food and Drug Administration has issued warnings to 3 companies selling kratom-containing products with unsubstantiated claims regarding their effectiveness in conditions that include opioid withdrawal and addiction and chronic pain.

Court-Mandated Substance Abuse Treatment: Exploring the Ethics and Efficacy

Court-Mandated Substance Abuse Treatment: Exploring the Ethics and Efficacy

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While many treatments for substance use disorder are not evidence based, several evidence-based approaches have shown effectiveness in court-mandated treatment settings.

HIV Viral Suppression Rates in Psychiatric Inpatients With Comorbid Substance Use Disorders

HIV Viral Suppression Rates in Psychiatric Inpatients With Comorbid Substance Use Disorders

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A substantial proportion of these individuals diagnosed with HIV, psychiatric disorders, and substance use disorders are out of care and urgently require intervention.

Long-acting buprenorphine depot injections may be efficacious in treatment of opioid use disorder

Weekly or monthly buprenorphine depot injections were non-inferior to daily sublingual buprenorphine/naloxone in maintaining no evidence of illicit opioid use at 24 weeks in outpatients with opioid use disorder.

Unit-dose packaging of buprenorphine-naloxone associated with reduced pediatric unintentional exposures

Pediatric unintentional opioid exposures decreased by more than 75% following the introduction of child-resistant unit-dose packaging.

First Nonopioid Drug Approved for Managing Opioid Withdrawal Symptoms

First Nonopioid Drug Approved for Managing Opioid Withdrawal Symptoms

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Lucemyra, a selective alpha 2-adrenergic receptor agonist, works by reducing the release of norepinephrine and decreasing sympathetic tone.

Opioid-Related Payments Linked to Increase in Opioid Rx

Opioid-Related Payments Linked to Increase in Opioid Rx

Receipt of opioid-related payments from industry in 2014 was associated with increased opioid prescribing in 2015.

Sources of Misused Opioids in Older Adults

Sources of Misused Opioids in Older Adults

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Recent physician-prescribed opioids represent the main source of provenance of the drug in individuals age ≥65 years who misuse them.

Contribution of Synthetic Opioids to Drug Overdose Deaths

Contribution of Synthetic Opioids to Drug Overdose Deaths

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Opioids were the leading contributor to drug overdose deaths between 2015 and 2016.

Prenatal Exposure to Opiates, Illicit Substances Associated With ADHD, Autism in Offspring

Prenatal Exposure to Opiates, Illicit Substances Associated With ADHD, Autism in Offspring

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The results of this study suggest that children prenatally exposed to substances should receive early mental health assessment.

How the City of San Francisco Is Tackling the Intertwined HIV/HCV and Opioid Epidemics

How the City of San Francisco Is Tackling the Intertwined HIV/HCV and Opioid Epidemics

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Katie Burk, MPH, presented measures undertaken by the city of San Francisco to provide integrated responses to the concurrent HIV/HCV and opioid public health epidemics.

Talk therapy, modified for literacy level, helps ease chronic pain for disadvantaged populations

Both modified cognitive behavioral therapy (CBT) and pain education (EDU) interventions were associated with improved pain in patients with disadvantaged backgrounds.

Significant variation in mortality trends in substance use disorders among US counties

Mortality rates decreased for alcohol use disorders, self-harm, and interpersonal violence between 1980 and 2014. Mortality rates for drug use disorders increased both nationally and in each county over the same period.

Little Packaging Information on Storage, Disposal of Opioid Pain-Relievers

Little Packaging Information on Storage, Disposal of Opioid Pain-Relievers

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Package inserts of opioid analgesics may not consistently provide information regarding safe drug storage and/or disposal.

Treatment Duration of Extended-Release Naltrexone for Opioid Dependence and Outcomes

Treatment Duration of Extended-Release Naltrexone for Opioid Dependence and Outcomes

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A longer duration of extended-release naltrexone treatment in individuals with opioid dependence was associated with improved outcomes and reduced rates of relapse.

Mortality Rates for Substance Use Disorders, Intentional Injuries Vary Widely By County

Mortality Rates for Substance Use Disorders, Intentional Injuries Vary Widely By County

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Researchers calculated age-standardized mortality rates on a county level in the United States between 1980 and 2014, specifically examining rates for self-harm, interpersonal violence, alcohol use, and drug use.

Does Access to Medical Cannabis Reduce Risk for Opioid Abuse?

Does Access to Medical Cannabis Reduce Risk for Opioid Abuse?

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While results so far may seem to support a link between increased access to cannabis and a reduction in prescription opioid use, findings from a study published in 2018 found otherwise.

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