Abuse-deterrent opioid formulations have not yet been widely accepted despite their proposed value in reducing opioid abuse and related mortality. Many of the current barriers to broader use are related to their higher cost compared with conventional formulations.
Children often fill outpatient opioid prescriptions, with the most common indication for dental procedures.
Buprenorphine and methadone maintenance treatment was associated with reduced death in opioid users. No significant associations were found between naltrexone and all-cause mortality or opioid-related mortality.
The US Surgeon General released an advisory urging increased availability of the opioid overdose-reversing drug naloxone earlier this year.
A novel, innovative initiative is being developed to help end addiction over the long term.
There is a marked excess of deaths among US adults who experience a nonfatal opioid overdose.
Oxycodone and morphine are more likely to contain messaging on package inserts describing safe storage and disposal methods compared with other commonly used and misused opioid analgesics.
Patterns associated with opioid overdose include overlapping prescriptions, use of more than one prescriber or pharmacy, and use of out-of-state prescribers or pharmacies.
Higher daily average inpatient pain scores and higher postoperative opioid consumption are associated with a subsequent persistent opioid use.
The US Drug Enforcement Administration's 2014 ruling to reschedule hydrocodone combination products coincided with an increase in illicit trading of opioids through online illicit markets.
Electrical pulses are sent through small needles that are inserted in the ear to combat the early stages of detoxification, leading to stabilization.
Nine online networks, operating 53 websites, have been warned that they must stop illegally marketing potentially dangerous versions of opioid medications.
Non-research industry payments to physicians may be associated with increases in opioid prescribing rates.
The US Food and Drug Administration has issued warnings to 3 companies selling kratom-containing products with unsubstantiated claims regarding their effectiveness in conditions that include opioid withdrawal and addiction and chronic pain.
While many treatments for substance use disorder are not evidence based, several evidence-based approaches have shown effectiveness in court-mandated treatment settings.
A substantial proportion of these individuals diagnosed with HIV, psychiatric disorders, and substance use disorders are out of care and urgently require intervention.
Weekly or monthly buprenorphine depot injections were non-inferior to daily sublingual buprenorphine/naloxone in maintaining no evidence of illicit opioid use at 24 weeks in outpatients with opioid use disorder.
Unit-dose packaging of buprenorphine-naloxone associated with reduced pediatric unintentional exposuresMay 22, 2018
Pediatric unintentional opioid exposures decreased by more than 75% following the introduction of child-resistant unit-dose packaging.
Lucemyra, a selective alpha 2-adrenergic receptor agonist, works by reducing the release of norepinephrine and decreasing sympathetic tone.
Receipt of opioid-related payments from industry in 2014 was associated with increased opioid prescribing in 2015.
Recent physician-prescribed opioids represent the main source of provenance of the drug in individuals age ≥65 years who misuse them.
Opioids were the leading contributor to drug overdose deaths between 2015 and 2016.
The results of this study suggest that children prenatally exposed to substances should receive early mental health assessment.
Katie Burk, MPH, presented measures undertaken by the city of San Francisco to provide integrated responses to the concurrent HIV/HCV and opioid public health epidemics.
Both modified cognitive behavioral therapy (CBT) and pain education (EDU) interventions were associated with improved pain in patients with disadvantaged backgrounds.
Mortality rates decreased for alcohol use disorders, self-harm, and interpersonal violence between 1980 and 2014. Mortality rates for drug use disorders increased both nationally and in each county over the same period.
Package inserts of opioid analgesics may not consistently provide information regarding safe drug storage and/or disposal.
A longer duration of extended-release naltrexone treatment in individuals with opioid dependence was associated with improved outcomes and reduced rates of relapse.
Researchers calculated age-standardized mortality rates on a county level in the United States between 1980 and 2014, specifically examining rates for self-harm, interpersonal violence, alcohol use, and drug use.
While results so far may seem to support a link between increased access to cannabis and a reduction in prescription opioid use, findings from a study published in 2018 found otherwise.
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