REM Sleep Disorder Linked to Neurocognitive Disorders
the Psychiatry Advisor take:
One sleep disorder, REM behavior disorder, could be a sign of impending neurocognitive disease, including Parkinson's and dementia, say scientists presenting their research at the Society of Nuclear Medicine and Molecular Imaging's 2014 Annual Meeting.
Researchers are not sure why spontaneous and unexplained disturbance in REM sleep should lead to a neurocognitive disease like Parkinson's, but new longitudinal imaging data show a clear correlation between idiopathic REM behavior disorder and dysfunction of the dopamine transporter system involved in a wide range of vital brain functions, including memory and motor control. Dysfunction associated with dopamine in the brain marks the first hints of Parkinson's disease.
"Our SPECT study showed a trend toward decreased dopamine transporter density in the brain and Parkinsonism in the follow-up data of patients with REM sleep disorder who had no previous evidence of neurodegenerative disease," said Hongyoon Choi, MD, a PhD candidate and researcher in the department of molecular medicine and biopharmaceutical sciences at Seoul National University Bundang Hospital, Sungnam, Korea. "To our knowledge, a study looking at a long-term link between the two has never been conducted before."
Sleep disorder linked to development of progressive brain diseases such as Parkinson's
Sign Up for Free e-newsletters
Psychiatry Advisor Articles
- Transference in the Age of #MeToo: What Counts as Harassment From a Patient?
- Should Physicians Treat Family and Friends? Three Experts Weigh In
- Predictors of Long-term Medication Adherence in Children With ADHD
- Influence of Psychostimulants on BMI and Height in Youth With ADHD
- Medication Adherence Predictors in Patients With Severe Psychiatric Disorders
- Court-Mandated Substance Abuse Treatment: Exploring the Ethics and Efficacy
- ADHD Treatments
- Esketamine Nasal Spray: A New Treatment Possibility for Treatment-Resistant Depression
- Pharmacogenetics in Psychiatry: Promising Developments and Potential Pitfalls
- Substance Abuse and Primary Psychosis: A Closer Look
- Poverty, Neighborhood May Affect Outcomes in Systemic Lupus Erythematosus
- Herpesvirus Abundant in Alzheimer Disease Brain, New Study Finds
- Rate of Death Up in Year After Non-Fatal Opioid Overdose
- NIH Initiative Aims to Address Opioid Misuse Over Long Term
- Nutrition Meets Science in Culinary Medicine Curriculum