Parkinson's-affected brains that receive neuron transplants appear healthy after 14 years

Share this content:

the Psychiatry Advisor take:

When transplanted into the midbrains of adult patients with Parkinson's disease, dopamine neurons derived from fetal tissue can remain healthy for many years. The findings reported in the journal Cell Reports suggest that transplanted neurons don't degenerate over time as some had suggested and feared they would, which provides further rationale for pursuing stem cells as a source for transplant-ready dopamine neurons, according to the researchers.

"Our findings show a robust expression of dopamine transporters and a lack of abnormal mitochondrial morphology in implanted dopamine neurons for at least 14 years after transplantation," said Ole Isacson of Harvard University and McLean Hospital. "Our data therefore suggest that transplanted dopamine neurons can remain healthy and functional for decades."

In the new study, Isacson and his colleagues examined dopamine neurons in five patients who had received fetal cell transplantation four to 14 years earlier. Their examination showed normal expression of dopamine transporters. The transplanted dopamine neurons also appeared to remain healthy and functional over time, with no signs of the degeneration characteristic of Parkinson's disease.

Parkinson's-affected brains that receive neuron transplants appear healthy after 14 years
Parkinson's-affected brains that receive neuron transplants appear healthy after 14 years
When transplanted into the midbrains of adult patients with Parkinson's disease, dopamine neurons derived from fetal tissue can remain healthy for many years. The findings reported in the Cell Press journal Cell Reports suggest that transplanted neurons don't degenerate over time as some had ...
READ FULL ARTICLE From Medical News Today
You must be a registered member of Psychiatry Advisor to post a comment.

Sign Up for Free e-newsletters