Neurocognitive

Cannabis Use in Adolescence Associated With Poorer Mental Health Outcomes

Cannabis Use in Adolescence Associated With Poorer Mental Health Outcomes

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These results provide strong evidence for the deleterious and prolonged effects of cannabis use in adolescence.

MRI Informative for Long-term Prognosis of Traumatic Brain Injury

MRI Informative for Long-term Prognosis of Traumatic Brain Injury

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This research supports MRI as a prognostic tool following TBI and highlights several important lesion patterns correlated with poor long-term outcomes.

Positive Link Between Air Pollution, Diagnosis of Dementia

Positive Link Between Air Pollution, Diagnosis of Dementia

There is a positive association between residential levels of air pollution and being diagnosed with dementia.

Anxiety Increases Freezing of Gait Severity in Individuals With Parkinson Disease

Anxiety Increases Freezing of Gait Severity in Individuals With Parkinson Disease

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The authors suggest that anxiety should be routinely evaluated in patients with Parkinson disease who experience freezing of gait.

Prevalence of Alzheimer Disease, Related Dementia Set to Double

Prevalence of Alzheimer Disease, Related Dementia Set to Double

The burden of Alzheimer disease and related dementias (ADRD) is expected to increase to 3.3% in the United States by 2060.

PET imaging of tau may help distinguish Alzheimer Disease from other neurodegenerative disorders

In this cross-sectional study, the tau marker [18F]flortaucipir accurately distinguished Alzheimer Disease dementia from other non-AD neurodegenerative disorders about 90% of the time.

Improved cardiovascular health associated with lower incidence of dementia in older adults

In this prospective cohort study, older patients with more optimal cardiovascular health metrics had a lower rate of developing dementia in a dose-dependent manner.

Reducing Off-Label Quetiapine Prescribing the Old-Fashioned Way: Snail Mail

Reducing Off-Label Quetiapine Prescribing the Old-Fashioned Way: Snail Mail

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Despite the associated risk for death and cognitive decline, "off-label" prescribing of antipsychotics in patients with dementia has increased.

Cortisol Levels May Contribute to Global Cognitive Decline in Elderly Adults With Depression

Cortisol Levels May Contribute to Global Cognitive Decline in Elderly Adults With Depression

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These data indicate that cortisol levels may contribute to the cognitive decline observed in elderly adults with late-life depression.

VAT Score Improves Predictive Value of Mini-Mental State Examination for Dementia

VAT Score Improves Predictive Value of Mini-Mental State Examination for Dementia

Administering the Visual Association Test improves the predictive value of the Mini-Mental State Examination score for dementia.

Traumatic brain injury associated with higher rate of suicide

In this retrospective study, Traumatic Brain Injury (TBI) was associated with a doubling in deaths by suicide, especially within the 6 months post-TBI.

TBI Linked to Increased Suicide Risk

TBI Linked to Increased Suicide Risk

Individuals with medical contact for traumatic brain injury have increased risk for suicide.

Behavioral Executive Dysfunction Associated With Chronic Kidney Disease

Behavioral Executive Dysfunction Associated With Chronic Kidney Disease

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Further assessment of this relationship and its underlying mechanisms may help clinicians anticipate the likelihood of patients' adherence to risk-reducing habits.

Both Abstinence and High Alcohol Use Linked to Dementia

Both Abstinence and High Alcohol Use Linked to Dementia

Abstinence in midlife and consumption of more than 14 units of alcohol per week are associated with increased risk of dementia.

Feeling Young May Be Reflected in Brain Structure

Feeling Young May Be Reflected in Brain Structure

People who feel younger than their age show fewer signs of brain aging than those who feel their age or older than their age.

Increased Levels of Human Herpesvirus Identified in Alzheimer Disease

Increased Levels of Human Herpesvirus Identified in Alzheimer Disease

Participants with Alzheimer disease have increased levels of 2 strains of human herpesvirus.

Sugary Drinks, Other Added Sugars May Up Risk for Alzheimer Disease

Sugary Drinks, Other Added Sugars May Up Risk for Alzheimer Disease

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Drinking sugary beverages has been previously linked to markers of preclinical Alzheimer disease, but the risk associated with consuming added sugars is not established.

Intensive Blood Pressure Control Cuts Combined Mild Cognitive Impairment, Dementia Risk

Intensive Blood Pressure Control Cuts Combined Mild Cognitive Impairment, Dementia Risk

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In the previous SPRINT study, researchers compared an intensive BP reduction strategy (target systolic BP <120 mmHg) vs standard BP reduction strategy (target systolic BP <140 mmHg).

Cannabinoid Shows Promise for Reducing Agitation, Aggression in Alzheimer Disease

Cannabinoid Shows Promise for Reducing Agitation, Aggression in Alzheimer Disease

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Although treatment with nabilone significantly improved agitation, cognition, and nutrition, the authors cautioned that sedation should be closely monitored.

Details of Montreal Cognitive Assessment Widely Publicized After President Donald Trump's Evaluation

Details of Montreal Cognitive Assessment Widely Publicized After President Donald Trump's Evaluation

Many published news articles included details of the Montreal Cognitive Assessment (MoCA) in association with President Trump, some of which invited readers to self-administer the test.

Association Between Alcohol Consumption, Cognitive Function Revealed

Association Between Alcohol Consumption, Cognitive Function Revealed

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Participants were drawn from the Health and Retirement Study, which provided multiple observations, genetic information, and previous alcohol use.

Some Statins May Be Associated With Cognition, Memory Deficits

Some Statins May Be Associated With Cognition, Memory Deficits

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Given the lack of differences seen via the NIS, the authors suggested that subjective questionnaires may not be a trustworthy method to assess possible statin-associated cognitive deficits.

Diclofenac Use Slows Cognitive Decline in Alzheimer Disease

Diclofenac Use Slows Cognitive Decline in Alzheimer Disease

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Results showed that most common NSAIDs, including aspirin, ibuprofen, naproxen, and celecoxib, did not alter cognitive degeneration in patients with mild cognitive impairment or Alzheimer disease.

Effect of ACE Inhibitors on Cognition in Alzheimer Disease Dementia

Effect of ACE Inhibitors on Cognition in Alzheimer Disease Dementia

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The genetically-mediated effects of angiotensin-converting enzyme (ACE) inhibitors showed an improvement in cognition in patients with Alzheimer disease dementia but not in functionality.

Aducanumab Beneficial in Cognitive, Functional Scores for Alzheimer Disease

Aducanumab Beneficial in Cognitive, Functional Scores for Alzheimer Disease

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The analysis suggests a beneficial effect of aducanumab on functional and cognitive domain scores in adults with Alzheimer disease.

Memantine Plus Cholinesterase Inhibitors Improves Psychosis, Neurobehavioral Symptoms in Alzheimer Disease

Memantine Plus Cholinesterase Inhibitors Improves Psychosis, Neurobehavioral Symptoms in Alzheimer Disease

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Investigators pooled data from patients from 3 phase 3, 24-week, randomized, placebo-controlled trials of MEM in patients with Alzheimer disease receiving concurrent ChEIs.

Cognitive Impairment Profiles Differ Between Parkinson Disease and Alzheimer Disease

Cognitive Impairment Profiles Differ Between Parkinson Disease and Alzheimer Disease

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As the neurodegenerative processes of Alzheimer disease and Parkinson disease are different, early cognitive impairment also present differently in these diseases.

Visual Hallucinations in Dementia and Parkinson Disease: Assessment of Patient Experiences

Visual Hallucinations in Dementia and Parkinson Disease: Assessment of Patient Experiences

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Patients who felt the situation was "abnormal" were less likely to seek help. This trend was more common in patients with Parkinson disease than patients with dementia, although both described feeling "embarrassed or ashamed."

Telemedicine Intervention for Neuropsychiatric Symptoms in Long-term Care Facilities

Telemedicine Intervention for Neuropsychiatric Symptoms in Long-term Care Facilities

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Researchers of the DETECT study aim to assess the potential for future implementation of telemedicine consultation for managing neuropsychiatric symptoms in long-term care facilities.

FDA Approves New Nuplazid Formulation, Dosage Strength

FDA Approves New Nuplazid Formulation, Dosage Strength

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Nuplazid, a non-dopaminergic, selective serotonin inverse agonist, targets 5-HT2A receptors that are thought to be involved in Parkinson disease psychosis.

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