These results provide strong evidence for the deleterious and prolonged effects of cannabis use in adolescence.
This research supports MRI as a prognostic tool following TBI and highlights several important lesion patterns correlated with poor long-term outcomes.
There is a positive association between residential levels of air pollution and being diagnosed with dementia.
The authors suggest that anxiety should be routinely evaluated in patients with Parkinson disease who experience freezing of gait.
The burden of Alzheimer disease and related dementias (ADRD) is expected to increase to 3.3% in the United States by 2060.
In this cross-sectional study, the tau marker [18F]flortaucipir accurately distinguished Alzheimer Disease dementia from other non-AD neurodegenerative disorders about 90% of the time.
In this prospective cohort study, older patients with more optimal cardiovascular health metrics had a lower rate of developing dementia in a dose-dependent manner.
Despite the associated risk for death and cognitive decline, "off-label" prescribing of antipsychotics in patients with dementia has increased.
These data indicate that cortisol levels may contribute to the cognitive decline observed in elderly adults with late-life depression.
Administering the Visual Association Test improves the predictive value of the Mini-Mental State Examination score for dementia.
In this retrospective study, Traumatic Brain Injury (TBI) was associated with a doubling in deaths by suicide, especially within the 6 months post-TBI.
Individuals with medical contact for traumatic brain injury have increased risk for suicide.
Further assessment of this relationship and its underlying mechanisms may help clinicians anticipate the likelihood of patients' adherence to risk-reducing habits.
Abstinence in midlife and consumption of more than 14 units of alcohol per week are associated with increased risk of dementia.
People who feel younger than their age show fewer signs of brain aging than those who feel their age or older than their age.
Participants with Alzheimer disease have increased levels of 2 strains of human herpesvirus.
Drinking sugary beverages has been previously linked to markers of preclinical Alzheimer disease, but the risk associated with consuming added sugars is not established.
In the previous SPRINT study, researchers compared an intensive BP reduction strategy (target systolic BP <120 mmHg) vs standard BP reduction strategy (target systolic BP <140 mmHg).
Although treatment with nabilone significantly improved agitation, cognition, and nutrition, the authors cautioned that sedation should be closely monitored.
Details of Montreal Cognitive Assessment Widely Publicized After President Donald Trump's EvaluationJuly 26, 2018
Many published news articles included details of the Montreal Cognitive Assessment (MoCA) in association with President Trump, some of which invited readers to self-administer the test.
Participants were drawn from the Health and Retirement Study, which provided multiple observations, genetic information, and previous alcohol use.
Given the lack of differences seen via the NIS, the authors suggested that subjective questionnaires may not be a trustworthy method to assess possible statin-associated cognitive deficits.
Results showed that most common NSAIDs, including aspirin, ibuprofen, naproxen, and celecoxib, did not alter cognitive degeneration in patients with mild cognitive impairment or Alzheimer disease.
The genetically-mediated effects of angiotensin-converting enzyme (ACE) inhibitors showed an improvement in cognition in patients with Alzheimer disease dementia but not in functionality.
The analysis suggests a beneficial effect of aducanumab on functional and cognitive domain scores in adults with Alzheimer disease.
Memantine Plus Cholinesterase Inhibitors Improves Psychosis, Neurobehavioral Symptoms in Alzheimer DiseaseJuly 25, 2018
Investigators pooled data from patients from 3 phase 3, 24-week, randomized, placebo-controlled trials of MEM in patients with Alzheimer disease receiving concurrent ChEIs.
As the neurodegenerative processes of Alzheimer disease and Parkinson disease are different, early cognitive impairment also present differently in these diseases.
Patients who felt the situation was "abnormal" were less likely to seek help. This trend was more common in patients with Parkinson disease than patients with dementia, although both described feeling "embarrassed or ashamed."
Researchers of the DETECT study aim to assess the potential for future implementation of telemedicine consultation for managing neuropsychiatric symptoms in long-term care facilities.
Nuplazid, a non-dopaminergic, selective serotonin inverse agonist, targets 5-HT2A receptors that are thought to be involved in Parkinson disease psychosis.
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