Neurocognitive

TBI Linked to Increased Suicide Risk

TBI Linked to Increased Suicide Risk

Individuals with medical contact for traumatic brain injury have increased risk of suicide.

Behavioral Executive Dysfunction Associated With Chronic Kidney Disease

Behavioral Executive Dysfunction Associated With Chronic Kidney Disease

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Further assessment of this relationship and its underlying mechanisms may help clinicians anticipate the likelihood of patients' adherence to risk-reducing habits.

Both Abstinence and High Alcohol Use Linked to Dementia

Both Abstinence and High Alcohol Use Linked to Dementia

Abstinence in midlife and consumption of more than 14 units of alcohol per week are associated with increased risk of dementia.

Feeling Young May Be Reflected in Brain Structure

Feeling Young May Be Reflected in Brain Structure

People who feel younger than their age show fewer signs of brain aging than those who feel their age or older than their age.

Increased Levels of Human Herpesvirus Identified in Alzheimer Disease

Increased Levels of Human Herpesvirus Identified in Alzheimer Disease

Participants with Alzheimer disease have increased levels of 2 strains of human herpesvirus.

Sugary Drinks, Other Added Sugars May Up Risk for Alzheimer Disease

Sugary Drinks, Other Added Sugars May Up Risk for Alzheimer Disease

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Drinking sugary beverages has been previously linked to markers of preclinical Alzheimer disease, but the risk associated with consuming added sugars is not established.

Intensive Blood Pressure Control Cuts Combined Mild Cognitive Impairment, Dementia Risk

Intensive Blood Pressure Control Cuts Combined Mild Cognitive Impairment, Dementia Risk

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In the previous SPRINT study, researchers compared an intensive BP reduction strategy (target systolic BP <120 mmHg) vs standard BP reduction strategy (target systolic BP <140 mmHg).

Cannabinoid Shows Promise for Reducing Agitation, Aggression in Alzheimer Disease

Cannabinoid Shows Promise for Reducing Agitation, Aggression in Alzheimer Disease

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Although treatment with nabilone significantly improved agitation, cognition, and nutrition, the authors cautioned that sedation should be closely monitored.

Details of Montreal Cognitive Assessment Widely Publicized After President Donald Trump's Evaluation

Details of Montreal Cognitive Assessment Widely Publicized After President Donald Trump's Evaluation

Many published news articles included details of the Montreal Cognitive Assessment (MoCA) in association with President Trump, some of which invited readers to self-administer the test.

Association Between Alcohol Consumption, Cognitive Function Revealed

Association Between Alcohol Consumption, Cognitive Function Revealed

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Participants were drawn from the Health and Retirement Study, which provided multiple observations, genetic information, and previous alcohol use.

Some Statins May Be Associated With Cognition, Memory Deficits

Some Statins May Be Associated With Cognition, Memory Deficits

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Given the lack of differences seen via the NIS, the authors suggested that subjective questionnaires may not be a trustworthy method to assess possible statin-associated cognitive deficits.

Diclofenac Use Slows Cognitive Decline in Alzheimer Disease

Diclofenac Use Slows Cognitive Decline in Alzheimer Disease

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Results showed that most common NSAIDs, including aspirin, ibuprofen, naproxen, and celecoxib, did not alter cognitive degeneration in patients with mild cognitive impairment or Alzheimer disease.

Effect of ACE Inhibitors on Cognition in Alzheimer Disease Dementia

Effect of ACE Inhibitors on Cognition in Alzheimer Disease Dementia

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The genetically-mediated effects of angiotensin-converting enzyme (ACE) inhibitors showed an improvement in cognition in patients with Alzheimer disease dementia but not in functionality.

Aducanumab Beneficial in Cognitive, Functional Scores for Alzheimer Disease

Aducanumab Beneficial in Cognitive, Functional Scores for Alzheimer Disease

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The analysis suggests a beneficial effect of aducanumab on functional and cognitive domain scores in adults with Alzheimer disease.

Memantine Plus Cholinesterase Inhibitors Improves Psychosis, Neurobehavioral Symptoms in Alzheimer Disease

Memantine Plus Cholinesterase Inhibitors Improves Psychosis, Neurobehavioral Symptoms in Alzheimer Disease

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Investigators pooled data from patients from 3 phase 3, 24-week, randomized, placebo-controlled trials of MEM in patients with Alzheimer disease receiving concurrent ChEIs.

Cognitive Impairment Profiles Differ Between Parkinson Disease and Alzheimer Disease

Cognitive Impairment Profiles Differ Between Parkinson Disease and Alzheimer Disease

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As the neurodegenerative processes of Alzheimer disease and Parkinson disease are different, early cognitive impairment also present differently in these diseases.

Visual Hallucinations in Dementia and Parkinson Disease: Assessment of Patient Experiences

Visual Hallucinations in Dementia and Parkinson Disease: Assessment of Patient Experiences

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Patients who felt the situation was "abnormal" were less likely to seek help. This trend was more common in patients with Parkinson disease than patients with dementia, although both described feeling "embarrassed or ashamed."

Telemedicine Intervention for Neuropsychiatric Symptoms in Long-term Care Facilities

Telemedicine Intervention for Neuropsychiatric Symptoms in Long-term Care Facilities

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Researchers of the DETECT study aim to assess the potential for future implementation of telemedicine consultation for managing neuropsychiatric symptoms in long-term care facilities.

FDA Approves New Nuplazid Formulation, Dosage Strength

FDA Approves New Nuplazid Formulation, Dosage Strength

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Nuplazid, a non-dopaminergic, selective serotonin inverse agonist, targets 5-HT2A receptors that are thought to be involved in Parkinson disease psychosis.

Benzodiazepines, Related Drugs Associated With Modestly Increased Risk for Alzheimer Disease

Benzodiazepines, Related Drugs Associated With Modestly Increased Risk for Alzheimer Disease

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Given the frequent use of benzodiazepines among older people, even a small increase in absolute risk may be a serious matter on a population level.

Herpesvirus Abundant in Alzheimer Disease Brain, New Study Finds

Herpesvirus Abundant in Alzheimer Disease Brain, New Study Finds

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While hundreds of published reports have made an argument for an association between Alzheimer disease and bacteria and viruses, the suggestion of a viral contribution to Alzheimer disease has not always been well received by the greater research community.

Higher Blood Pressure at Midlife Increases Risk for Dementia

Higher Blood Pressure at Midlife Increases Risk for Dementia

The risk of dementia is increased in 50-year-olds with blood pressure ≥130 mm Hg, which is below the current threshold for hypertension.

Cognitive Performance, Mood Deficits, White Matter Hyperintensities in Migraine

Cognitive Performance, Mood Deficits, White Matter Hyperintensities in Migraine

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Carefully assessing cognitive performance using a screening test to detect visuospatial/executive, attention, and memory dysfunction in patients with migraine.

Trials for Investigational Alzheimer Treatment Lanabecestat Discontinued

Trials for Investigational Alzheimer Treatment Lanabecestat Discontinued

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Phase 3 clinical trials for lanabecestat (Eli Lilly and AstraZeneca), an investigational Alzheimer disease treatment, are being discontinued for futility.

Lifetime Risks Temper Biomarker Tests for Alzheimer Disease Dementia

Lifetime Risks Temper Biomarker Tests for Alzheimer Disease Dementia

The lifetime risks of Alzheimer disease dementia vary considerably by age, gender, and the preclinical or clinical disease state.

Intellectual Activities in Later Life May Cut Dementia Risk

Intellectual Activities in Later Life May Cut Dementia Risk

There is a reduced risk for dementia for older Chinese adults actively participating in intellectual activities.

Examining the Content, Frequency of Auditory Hallucinations in Dementia

Examining the Content, Frequency of Auditory Hallucinations in Dementia

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These results highlight the risk for auditory hallucinations in certain subsets of patients with dementia with Lewy bodies and may be useful for clinicians in developing targeted treatment options.

Effects of Depressive Symptoms on Cognition, Markers of Brain Aging

Effects of Depressive Symptoms on Cognition, Markers of Brain Aging

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These findings suggest a strong association between greater depressive symptoms and markers of brain aging as well as impaired episodic memory.

Clinically Significant Anxiety Tied to Subsequent Dementia Risk

Clinically Significant Anxiety Tied to Subsequent Dementia Risk

These findings indicate that anxiety may be a risk factor for late-life dementia, excluding anxiety that is related to prodromal cognitive decline.

Mortality in Alzheimer Disease Not Strongly Associated With Antipsychotics

Mortality in Alzheimer Disease Not Strongly Associated With Antipsychotics

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These results suggest that antipsychotic exposure has no impact on relative mortality.

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