Neurocognitive Disorders

Methylphenidate & CBT Benefits TBI Patients with Cognitive Problems

Methylphenidate & CBT Benefits TBI Patients with Cognitive Problems

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These preliminary findings suggest that combined treatment with MAAT and methylphenidate can improve attention, episodic and working memory, and executive functioning following traumatic brain injury.

Exploring Possible Causes of Decreasing Dementia Rates In the US

Exploring Possible Causes of Decreasing Dementia Rates In the US

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Better management of cardiovascular risk factors and higher levels of education may have contributed to this improvement.

Advancing Pain Management: Human Studies

Advancing Pain Management: Human Studies

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Research on monogenic disorders has made vital contributions to all aspects of medical care, including our understanding of pain pathophysiology.

Medication Overuse Headache: Diagnosis & Treatment

Medication Overuse Headache: Diagnosis & Treatment

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The recovery time varies depending on which class of medication the patient is overusing.

Probability of Dementia Higher in Men Receiving Androgen Deprivation Therapy

Probability of Dementia Higher in Men Receiving Androgen Deprivation Therapy

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The longer the duration of ADT, the greater the risk of dementia.

Midlife Hypertension and Late-life Neurocognitive Status

Midlife Hypertension and Late-life Neurocognitive Status

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The American Heart Association issues a scientific statement on the possible link between chronic arterial hypertension and cognitive impairment.

The Effect of Cognitive Remediation Training on Functional Connectivity and Social Cognition in Schizophrenia

The Effect of Cognitive Remediation Training on Functional Connectivity and Social Cognition in Schizophrenia

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Study provides further evidence for the effects of cognitive enhancement intervention on brain functional connectivity and cognitive performance in patients with schizophrenia.

Inhaled Levodopa for 'Off' Periods in Parkinson Disease

Inhaled Levodopa for 'Off' Periods in Parkinson Disease

Levodopa pill can wear off, but a powdered version can help patients during off periods.

Executive Dysfunction in Idiopathic Depression vs Epilepsy-associated Depression

Executive Dysfunction in Idiopathic Depression vs Epilepsy-associated Depression

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Individuals suffering from depression, as well as persons diagnosed with temporal lobe epilepsy, present with dysfunction across several cognitive domains.

Gender-dependent Differences in Alzheimer Disease Diagnosis

Gender-dependent Differences in Alzheimer Disease Diagnosis

In 2016, an estimated 5.4 million US adults have Alzheimer disease.

T2D and Cognition: Role of Ghrelin System

T2D and Cognition: Role of Ghrelin System

Serum ghrelin levels may serve as a biomarker of executive function in patients with type 2 diabetes.

Sundowning: Phenomenology, Pathophysiology, and Treatment Approaches

Sundowning: Phenomenology, Pathophysiology, and Treatment Approaches

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Sundowning is a complex multifactorial condition that has eluded rigorous understanding of its pathophysiological causes.

Cognition in Depression: A Critical Domain for Health Outcomes, Measurement, and Treatment

Cognition in Depression: A Critical Domain for Health Outcomes, Measurement, and Treatment

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Dr. Roger McIntyre suggests that the clinical relevance of cognitive dysfunction for any individual patient can only be adjudicated on a case-by-case basis.

Investigating Superagers' Neuroanatomy, Memory Abilities

Investigating Superagers' Neuroanatomy, Memory Abilities

Most aging humans will develop some degree of decline in cognitive capacity.

Alcohol Consumption and Alzheimer Disease: A Brief Update

Alcohol Consumption and Alzheimer Disease: A Brief Update

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Basic Research Findings for the Practicing Clinician

Anxiety is a Risk Factor for Cognitive Decline and Dementia

Anxiety is a Risk Factor for Cognitive Decline and Dementia

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Most research to date has focused on the association between depression and dementia, but not many studies were performed to investigate the link between anxiety and dementia.

Cortical Molecular Markers Differentiate Psychotic, Bipolar Disorders

Cortical Molecular Markers Differentiate Psychotic, Bipolar Disorders

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The researchers quantified the transcript levels of GAD67, parvalbumin, somastatin, and Lhx6 in the prefrontal cortex.

Alzheimer Markers Detected in Healthy Individuals with Genetic AD Risk

Alzheimer Markers Detected in Healthy Individuals with Genetic AD Risk

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The effects of aggregate genetic AD risk are detectable before symptoms appear, even early in life.

CSF Biomarkers Improve Diagnosis in Patients with Psychiatric Disorders & Cognitive Symptoms

CSF Biomarkers Improve Diagnosis in Patients with Psychiatric Disorders & Cognitive Symptoms

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Distinguishing between psychiatric disorders and AD is crucial because of the differing prognosis and management of the two.

Urinary Biomarker of Parkinson Disease Identified

Urinary Biomarker of Parkinson Disease Identified

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To date, there are no validated biomarkers to independently assess Parkinson Disease diagnosis and prognosis, or to measure disease severity.

Molecular Abnormalities in the Hippocampus in Schizophrenia

Molecular Abnormalities in the Hippocampus in Schizophrenia

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Post mortem examination of human brain samples derived from individuals diagnosed with schizophrenia revealed widespread synaptic alterations in CA1 hippocampal subfield.

Managing Epilepsy in Patients With Intellectual Disability

Managing Epilepsy in Patients With Intellectual Disability

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The associated morbidities and deficits make epilepsy care for adults with intellectual disability complex.

No Evidence for Transmission of Alzheimer Pathology Through Blood Transfusions

No Evidence for Transmission of Alzheimer Pathology Through Blood Transfusions

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If transmission of neurodegenerative diseases such as dementia of any type, AD, or PD does occur, it is rare.

Cannabinoids Reduce Intraneuronal Beta Amyloid Protein Levels

Cannabinoids Reduce Intraneuronal Beta Amyloid Protein Levels

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Tetrahydrocannabinol (THC) is the main active chemical ingredient found in cannabis and is a potent cannabinoid receptor (CB)-1 agonist.

Risk of Developing Huntington Disease Higher Than Previously Thought

Risk of Developing Huntington Disease Higher Than Previously Thought

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The HD-associated CAG repeat with 36 or more repeats was found in 18 individuals.

There Is No Safe Level of Lead for Children

There Is No Safe Level of Lead for Children

Lead exposure is one of the most common preventable poisonings of childhood, and children are particularly sensitive to the effects of lead.

Parkinson Disease Incidence On The Rise Among American Men

Parkinson Disease Incidence On The Rise Among American Men

Declining smoking rates could be associated with higher incidence of parkinsonism and PD.

Physical Activity During Midlife Influences Late Life Verbal Memory Performance

Physical Activity During Midlife Influences Late Life Verbal Memory Performance

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Modifiable risk factors (eg, smoking, hypertension, sedentary behavior, overweight/obesity, and social engagement) contribute to nearly half of documented dementia cases.

Cognitive Ability and Brain Gray Matter in Adolescents With Type 2 Diabetes

Cognitive Ability and Brain Gray Matter in Adolescents With Type 2 Diabetes

High-resolution MRI revealed an association between less gray matter and the ability to pronounce and sound out unfamiliar words.

Leaky Blood-Brain Barrier Associated With Cognitive Decline in Early Alzheimer Disease

Leaky Blood-Brain Barrier Associated With Cognitive Decline in Early Alzheimer Disease

Cognitive test scores are negatively correlated with blood-brain barrier disruption in patients with early AD.

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