Metabolic Syndrome Associated with Risk of Mild Cognitive Impairment and Dementia

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Identifying individuals with metabolic syndrome may be a promising approach to prevent dementia.
Identifying individuals with metabolic syndrome may be a promising approach to prevent dementia.

(HealthDay News) — The incidence of mild cognitive impairment (MCI) and MCI progression to dementia is increased in association with metabolic syndrome (MetS), according to a study published in JAMA Neurology.

Tze Pin Ng, MD, from the National University of Singapore, and colleagues examined the correlation for MetS and its component cardiovascular risk factors with the incidence of MCI and its progression to dementia in a prospective longitudinal study. Participants were a population-based sample of 1519 cognitively normal adults aged 55 years and older (mean age, 64.9 years; 64.8% female).

 

The researchers found that the risk of incident MCI was increased in association with baseline characteristics of MetS (hazard ratio [HR], 1.46), central obesity (HR: 1.41), diabetes mellitus (HR: 2.84), dyslipidemia (HR: 1.48), and 3 or more component cardiovascular risk factors (HR: 1.58). The risk of MCI progression to dementia was increased in association with baseline characteristics of MetS (HR: 4.25), diabetes mellitus (HR: 2.47), and 3 or more component cardiovascular risk factors (HR: 4.92).

"The MetS was associated with an increased incidence of MCI and progression to dementia," the authors write. "Identifying individuals with diabetes mellitus or the MetS with or without MCI is a promising approach in early interventions to prevent or slow progression to dementia."

Reference

  1. Ng TP, Feng L, Nyunt MSZ, et al. Metabolic Syndrome and the Risk of Mild Cognitive Impairment and Progression to Dementia: Follow-up of the Singapore Longitudinal Ageing Study Cohort. JAMA Neurol. 2016; doi: 10.1001/jamaneurol.2015.4899.
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