Neurocognitive Disorders Archive

Early Evaluation for Epilepsy Surgery May Lead to Improved Cognitive Outcomes

Early Evaluation for Epilepsy Surgery May Lead to Improved Cognitive Outcomes

In order to maximize cognitive benefits in patients with epilepsy, early consideration of and evaluation for epilepsy surgery is key.

Patients With Excessive Daytime Sleepiness May Benefit From Sodium Oxybate

Patients With Excessive Daytime Sleepiness May Benefit From Sodium Oxybate

Sodium oxybate seems to be well tolerated in patients with Parkinson's disease and excessive daytime sleepiness.

Subjective Cognitive Decline Linked to Alzheimer Biomarker

Subjective Cognitive Decline Linked to Alzheimer Biomarker

There were associations found between SCD and region-specific tauopathy.

Is Hypertension Linked to an Increased Risk of Dementia?

Is Hypertension Linked to an Increased Risk of Dementia?

A recently published study reports that women who develop high blood pressure in their 40s could be at a higher risk for developing dementia later in life.

Cognitive Decline in Parkinson's Disease Accurately Predicted by Algorithm

Cognitive Decline in Parkinson's Disease Accurately Predicted by Algorithm

A new analytic model can now predict cognitive decline within 10 years of onset PD.

Families Shoulder Majority of Dementia Care Costs

Families Shoulder Majority of Dementia Care Costs

For individuals with dementia, lifetime care costs are increased.

Better Diagnostics Needed for Milder Neurocognitive Disorders Linked to HIV

Better Diagnostics Needed for Milder Neurocognitive Disorders Linked to HIV

New data were presented at the IAS Conference, pertaining to predictive factors and cognitive screening for HIV-associated neurocognitive disorders.

Opioid Receptors May Affect Later Pain Processing

Opioid Receptors May Affect Later Pain Processing

This study suggests a link between high reward receptor responses in the striatal cortex and expression of pain complaints 2 years later.

CNS Symptoms Apparent After Head Impacts in Soccer

CNS Symptoms Apparent After Head Impacts in Soccer

Head impacts in soccer are independently associated with moderate to very severe central nervous system (CNS) symptoms.

NfL Biomarker Assists With Parkinsonian Disorder Differentiation

NfL Biomarker Assists With Parkinsonian Disorder Differentiation

More specific biomarkers will be needed to differentiate between atypical parkinsonian disorders.

Methylphenidate & CBT Benefits TBI Patients with Cognitive Problems

Methylphenidate & CBT Benefits TBI Patients with Cognitive Problems

These preliminary findings suggest that combined treatment with MAAT and methylphenidate can improve attention, episodic and working memory, and executive functioning following traumatic brain injury.

Exploring Possible Causes of Decreasing Dementia Rates In the US

Exploring Possible Causes of Decreasing Dementia Rates In the US

Better management of cardiovascular risk factors and higher levels of education may have contributed to this improvement.

Midlife Hypertension and Late-life Neurocognitive Status

Midlife Hypertension and Late-life Neurocognitive Status

The American Heart Association issues a scientific statement on the possible link between chronic arterial hypertension and cognitive impairment.

Inhaled Levodopa for 'Off' Periods in Parkinson Disease

Inhaled Levodopa for 'Off' Periods in Parkinson Disease

Levodopa pill can wear off, but a powdered version can help patients during off periods.

Gender-dependent Differences in Alzheimer Disease Diagnosis

Gender-dependent Differences in Alzheimer Disease Diagnosis

In 2016, an estimated 5.4 million US adults have Alzheimer disease.

T2D and Cognition: Role of Ghrelin System

T2D and Cognition: Role of Ghrelin System

Serum ghrelin levels may serve as a biomarker of executive function in patients with type 2 diabetes.

Investigating Superagers' Neuroanatomy, Memory Abilities

Investigating Superagers' Neuroanatomy, Memory Abilities

Most aging humans will develop some degree of decline in cognitive capacity.

Statins May Be Protective Against Parkinson's in Diabetes

Statins May Be Protective Against Parkinson's in Diabetes

The study suggests that statins may serve a greater purpose beyond control of lipids and cardiovascular events.

Active Music Therapy May Be Beneficial in Parkinson's

Active Music Therapy May Be Beneficial in Parkinson's

Researchers saw a beneficial effect in tests examining frontal lobe function and improvement in memory.

Dopaminergic Control of Striatal Cholinergic Interneurons May Cause Antipsychotic-Associated Parkinsonism

Dopaminergic Control of Striatal Cholinergic Interneurons May Cause Antipsychotic-Associated Parkinsonism

Research examines the underlying mechanisms for the disabling adverse effects associated with antipsychotic medications.

CSF Biomarkers Improve Diagnosis in Patients with Psychiatric Disorders & Cognitive Symptoms

CSF Biomarkers Improve Diagnosis in Patients with Psychiatric Disorders & Cognitive Symptoms

Distinguishing between psychiatric disorders and AD is crucial because of the differing prognosis and management of the two.

Urinary Biomarker of Parkinson Disease Identified

Urinary Biomarker of Parkinson Disease Identified

To date, there are no validated biomarkers to independently assess Parkinson Disease diagnosis and prognosis, or to measure disease severity.

Parkinson Disease Incidence On The Rise Among American Men

Parkinson Disease Incidence On The Rise Among American Men

Declining smoking rates could be associated with higher incidence of parkinsonism and PD.

Acute HIV Infection Linked to Mild Neurologic Signs and Symptoms

Acute HIV Infection Linked to Mild Neurologic Signs and Symptoms

Neurologic symptoms resolved after 1 month of antiviral treatment in 90% of study participants.

FDA Approves Nuplazid for Parkinson's Disease Psychosis

FDA Approves Nuplazid for Parkinson's Disease Psychosis

The drug is the first of its kind to address PD psychosis without having an ill effect on motor symptoms.

Psychosomatic Symptoms Linked to Longer Recovery Period for Concussions

Psychosomatic Symptoms Linked to Longer Recovery Period for Concussions

Athletes presenting with psychosomatic symptoms before a concussion may have a longer recovery period.

Physical Activity Level Affects Rate of Cognitive Decline

Physical Activity Level Affects Rate of Cognitive Decline

Declines in processing sleep and episodic memory were observed in those with low levels of activity.

Possibly From Placebo Effect, Acupuncture Improves Fatigue in Parkinson's

Possibly From Placebo Effect, Acupuncture Improves Fatigue in Parkinson's

The researchers observed between-group differences between real and sham acupuncture treatment.

Antipsychotics May Boost Early Death Risk in Parkinson's

Antipsychotics May Boost Early Death Risk in Parkinson's

Unclear whether the medications or the disease are the key factor; study only shows an association.

Rosacea May Increase Risk of Parkinson's

Rosacea May Increase Risk of Parkinson's

Research found an association, but no cause-and-effect relationship, between rosacea and Parkinson's.

Cognitive Decline Has Greater Impact on Speech in Parkinson's

Cognitive Decline Has Greater Impact on Speech in Parkinson's

Those with cognitive difficulties struggle to follow conversations or recall words.

Cognitive Reserve May Influence Mild Cognitive Impairment

Cognitive Reserve May Influence Mild Cognitive Impairment

Researchers sought to understand sex differences in verbal memory deficits and its relationship to hippocampal volume.

SSRI May Improve Neurocognitive Disorder in HIV Patients

SSRI May Improve Neurocognitive Disorder in HIV Patients

Paroxetine use improved cognitive impairment and reduced inflammation in HIV patients.

Metabolic Syndrome Associated with Risk of Mild Cognitive Impairment and Dementia

Metabolic Syndrome Associated with Risk of Mild Cognitive Impairment and Dementia

Metabolic syndrome was linked to increased incidence of mild cognitive impairment and progression to dementia.

Poor Cardiovascular Fitness Linked to Decline in Brain Volume

Poor Cardiovascular Fitness Linked to Decline in Brain Volume

Poorer CV fitness, greater exercise BP in midlife linked to smaller brain volume 20 years later.

Proton Pump Inhibitors May Boost Dementia Risk

Proton Pump Inhibitors May Boost Dementia Risk

Avoiding the common prescription and OTC gastrointestinal drugs may help prevent development of dementia.

Subjective Memory Complaints Rarely Discussed With Docs

Subjective Memory Complaints Rarely Discussed With Docs

Of adults aged 45 years and older reporting recent check-up, only 25.2% reported SMCs.

Significant Weight Loss From Mid-Life Can Increase MCI Risk

Significant Weight Loss From Mid-Life Can Increase MCI Risk

Increasing weight loss, BMI from midlife to late life may be marker for mild cognitive impairment.

No Link Between Anesthesia in Middle Age and Mild Cognitive Impairment

No Link Between Anesthesia in Middle Age and Mild Cognitive Impairment

For adults, mild cognitive issues that may develop over time are unrelated, researchers say.

Physical Therapy May Not Help Parkinson's Patients

Physical Therapy May Not Help Parkinson's Patients

However, results should be interpreted with attention to the study details, Mayo doc says.

Lower Risk of Parkinson's In Men With Higher Uric Acid Concentration

Lower Risk of Parkinson's In Men With Higher Uric Acid Concentration

Men with higher urate concentrations had a lower future risk of developing Parkinson's, suggesting that urate could have a protective factor.

Dementia Med Lowers Risk of Falls in Parkinson's Patients

Dementia Med Lowers Risk of Falls in Parkinson's Patients

Those who took rivastigmine in study were 45% less likely to have an accident.

Could Cholesterol-Lowering Drug Simvastatin Treat Parkinson's?

Could Cholesterol-Lowering Drug Simvastatin Treat Parkinson's?

Results from a recent multiple sclerosis trial with simvastatin indicate that it could be an effective treatment to slow progression of Parkinson's.

Maker of Brain Games Lumosity Settles FTC Charges

Maker of Brain Games Lumosity Settles FTC Charges

Lumos Labs, the creators of Lumosity, will pay $2 million to settle Federal Trade Commission charges.

Exercise in Childhood Boosts Brain Function Later in Life

Exercise in Childhood Boosts Brain Function Later in Life

Exercise-induced alterations in microbiota produce extensive neural and metabolic benefits.

Anticholinergic Drugs Not Harmful to Parkinson's Patients

Anticholinergic Drugs Not Harmful to Parkinson's Patients

There was no difference in cognition between Parkinson's patients taking a high and lower level of anticholinergic medications.

Hepatitis C a Possible Risk Factor for Parkinson's Disease

Hepatitis C a Possible Risk Factor for Parkinson's Disease

Patients with hepatitis C were 2.5 times more likely to develop Parkinson's before adjustments.

Drug That Protects Dopamine Cells Eyed as Parkinson's Treatment

Drug That Protects Dopamine Cells Eyed as Parkinson's Treatment

In a mouse model of Parkinson's, LBT-3727 was able to protect dopamine-producing cells.

Pesticide-Contaminated Milk May Be Linked to Parkinson's Disease

Pesticide-Contaminated Milk May Be Linked to Parkinson's Disease

After performing brain autopsies, researchers found pesticide residue in 90% of the participants.

Children With Epilepsy Face Cognitive Impairment

Children With Epilepsy Face Cognitive Impairment

Study may be the first evidence associating white matter abnormalities with reduced cognitive ability in children with early-onset epilepsy.

Visual Response Test Could Be Biomarker for Early Parkinson's

Visual Response Test Could Be Biomarker for Early Parkinson's

Based on visual responses of fruit flies, the ones with mutations toward Parkinson's had increase neuronal activity to stimulation.

Rare Genetic Variants Linked to Familial Parkinson's Disease Risk

Rare Genetic Variants Linked to Familial Parkinson's Disease Risk

Researchers identified two genes with potentially damaging genetic variants that could affect familial Parkinson's susceptibility.

Visual Test Can Help Identify Early Signs of Cognitive Impairment

Visual Test Can Help Identify Early Signs of Cognitive Impairment

The test uses a device that produces visual flickers to measure visual processing speed.

New Criteria Developed to Better Diagnose, Treat Parkinson's

New Criteria Developed to Better Diagnose, Treat Parkinson's

The new criteria emphasizes that Parkinson's is more than a motor disorder, emphasizing the early stages of the disease.

Exercise Helps Ease Brain Aging

Exercise Helps Ease Brain Aging

In study involving female twins, the sibling with the greater leg strength maintained her mental abilities better and had fewer age-related brain changes.

No Conclusive Link Between Alcohol Consumption and Parkinson's

No Conclusive Link Between Alcohol Consumption and Parkinson's

Inconsistent conclusion among studies looking at the association may be the result of retrospective assessments, definition of drinkers.

Exercise May Mitigate Brain Aging

Exercise May Mitigate Brain Aging

Mice that engaged in regular exercise saw less structural deterioration in the brain.

Acupuncture Improves Walking in Parkinson's Patients

Acupuncture Improves Walking in Parkinson's Patients

The researchers observed significant increases in gait speed, step length, floor reaction force, and cadence after acupuncture.

Mechanism to Stop Lewy Body Formation Has Parkinson's Treatment Promise

Mechanism to Stop Lewy Body Formation Has Parkinson's Treatment Promise

Scientists may have discovered a way to stop the formation of Lewy bodies, protein clumps found in the brains of those with Parkinson's.

Cancer Drug Improves Parkinson's Symptoms and Progression

Cancer Drug Improves Parkinson's Symptoms and Progression

Nilotinib (Tasigna) improved cognition and motor skills in patients with Parkinson's and Lewy body dementia.

Cancer Drug May Improve Memory in Dementia, Alzheimer's

Cancer Drug May Improve Memory in Dementia, Alzheimer's

The drug, RGFP966, is thought to make neurons more plastic, allowing them to make connections and thus changes that can enhance memory.

Action Video Games May Improve Cognitive Function

Action Video Games May Improve Cognitive Function

Action-oriented video games may help to improve cognitive function.

Treating Parkinson's Psychosis With Antipsychotics May Boost Death Risk

Treating Parkinson's Psychosis With Antipsychotics May Boost Death Risk

PDP patients treated with antipsychotics were four times as likely to died following three to six months of treatment than those not on the meds.

Noninvasive Way to Target Brain Cells Impacted by Parkinson's Found

Noninvasive Way to Target Brain Cells Impacted by Parkinson's Found

A non-threatening virus was delivered a genetic "switch" to cholinergic neurons in the brains of rat cells, followed by a drug to activate the "switch."

Brain Stimulation Can Improve Motor Function in Parkinson's

Brain Stimulation Can Improve Motor Function in Parkinson's

Parkinson's disease patients who received transcranial direct current stimulation saw a 25% improvement in motor symptoms.

Asthma May Increase Risk of Developing Parkinson's

Asthma May Increase Risk of Developing Parkinson's

Highest risk of subsequent Parkinson's was with asthma patients with more frequent hospital admissions.

'Brain Cell Burnout' May Be at Root of Parkinson's

'Brain Cell Burnout' May Be at Root of Parkinson's

Discovery could potentially lead to new treatments.

Fat Build-Up in Brain May Accelerate Alzheimer's

Fat Build-Up in Brain May Accelerate Alzheimer's

Compounds that inhibit the enzymes that cause the deposits are being tested as obesity treatments, but could have potential for Alzheimer's too.

Exercise, Omega-3 Doesn't Help Cognition in Elderly

Exercise, Omega-3 Doesn't Help Cognition in Elderly

Researchers say eating a more healthy diet may have more of an effect.

Eye Pigment Levels May Provide Biomarker of Cognitive Function

Eye Pigment Levels May Provide Biomarker of Cognitive Function

Biomarker may provide a way of detecting patients at risk of developing Alzheimer's at earlier stage than currently available.

'Stress Hormone' Levels in Seniors Could Determine Cognitive Decline

'Stress Hormone' Levels in Seniors Could Determine Cognitive Decline

Higher salivary cortisol levels in the evening was tied to lower brain volume and worse cognitive function.

Biomarkers May Predict Dementia in Parkinson's Disease

Biomarkers May Predict Dementia in Parkinson's Disease

In people with PD, high neurofilament light chain protein, low Aβ1-42, and high heart fatty acid-binding protein was associate with PD dementia.

Physical Activity Tied to Fewer Symptoms in Kids with Multiple Sclerosis

Physical Activity Tied to Fewer Symptoms in Kids with Multiple Sclerosis

Participation in strenuous physical activity correlated with smaller T2 lesion volumes and lower annualized relapse rate.

New Huntington's Disease Treatment to Be Reviewed by FDA

New Huntington's Disease Treatment to Be Reviewed by FDA

The FDA has accepted Teva's New Drug Application for deutetrabenazine to treat chorea associated with Huntington's disease.

Side Sleeping Best for Clearing Brain of Beta Amyloid

Side Sleeping Best for Clearing Brain of Beta Amyloid

Sleeping on one's side may be the best position for removal of waste from the brain, based on study in rodents.

MRI Gadolinium Deposits in Brain Being Investigated

MRI Gadolinium Deposits in Brain Being Investigated

It's not clear whether the brain deposits are harmful or have long-term health effects.

Common Diabetes Drugs May Reduce Risk of Parkinson's

Common Diabetes Drugs May Reduce Risk of Parkinson's

Patients who used glitazones were 28% less likely to be diagnosed with Parkinson's than those who never took one of the medications.

Malaria Drugs Examined As Potential Parkinson's Treatment

Malaria Drugs Examined As Potential Parkinson's Treatment

Rats with Parkinson's symptoms given chloroquine and amodiaquine, two popular antimalaria drugs, showed improvements in movement.

Protein That Builds Up With Age Linked to Memory Problems

Protein That Builds Up With Age Linked to Memory Problems

Stopping the buildup of beta-2-microglobulin (B2M) protein in the blood and brain may prevent or reverse memory problems.

Excessive Sleepiness Worsens in Parkinson's As Disease Progresses

Excessive Sleepiness Worsens in Parkinson's As Disease Progresses

Researchers find narcolepsy symptoms the most severe in patients taking dopamine agonists, so clinicians should be cautious in using them.

Inadequate Funding, Patient Fear Hinder Parkinson's Research

Inadequate Funding, Patient Fear Hinder Parkinson's Research

Improved communication and information between Parkinson's researchers and patients could lead to greater success in Parkinson's clinical trials.

Mortality Risk Increased for Parkinson's Patients on Antipsychotics

Mortality Risk Increased for Parkinson's Patients on Antipsychotics

Parkinson's patients who took any antipsychotic were more than twice as likely to die within 180 days than those not on one.

Blackcurrant Juice Could Reduce Depression, Parkinson's Symptoms

Blackcurrant Juice Could Reduce Depression, Parkinson's Symptoms

Juice from a variety of New Zealand blackcurrants led to improvements in mood, attention and mental fatigue in patients.

High Fat, Sugar Diets Can Impede Cognitive Functioning

High Fat, Sugar Diets Can Impede Cognitive Functioning

Mice given diets high in sugar and fat demonstrated diminished cognitive functioning compared with mice on regular diets.

Apomorphine Injection Rapidly Improves Morning Akinesia in Parkinson's

Apomorphine Injection Rapidly Improves Morning Akinesia in Parkinson's

Apomorphine that is injected was shown to work faster than oral levodopa to treat morning akinesia in Parkinson's disease patients.

Inhaled Levodopa Rapidly Enhances Motor Function in Parkinson's

Inhaled Levodopa Rapidly Enhances Motor Function in Parkinson's

Parkinson's disease patients who were given the inhaled levodopa showed rapid improvement in motor symptoms and a reduction in "off" hours daily.

Parkinson's Disease Associated With Higher Risk of Many Cancer Types

Parkinson's Disease Associated With Higher Risk of Many Cancer Types

Taiwanese study shows that Parkinson's disease was associated with a higher risk of 16 types of cancer, including lung and brain tumors.

Trans Fats in Diet May Adversely Affect Memory in Men

Trans Fats in Diet May Adversely Affect Memory in Men

Men who consumed more trans fats daily were able to remember fewer words in a memory test than others who ate fewer such fats.

Parkinson's Brain Stimulation Device Gains FDA Approval

Parkinson's Brain Stimulation Device Gains FDA Approval

The Brio Neurostimulation System continuously delivers low-intensity electrical pulses to the brain to treat Parkinson's and essential tremor.

Novel Parkinson's Drug Dosed Once Daily Significantly Reduces Off-Time

Novel Parkinson's Drug Dosed Once Daily Significantly Reduces Off-Time

Opicapone, a COMT inhibitor added to levodopa, reduced absolute off-time by two hours compared to placebo in Parkinson's patients.

Severe Nonmotor Symptoms Found in Many Early Parkinson's Patients

Severe Nonmotor Symptoms Found in Many Early Parkinson's Patients

More than one-third of early Parkinson's patients, whether or not taking medication, reported severe fatigue, memory difficulties and urinary urgency.

Blood Type May Influence Risk of Cognitive Decline, Alzheimer's

Blood Type May Influence Risk of Cognitive Decline, Alzheimer's

Individuals with type 'O' blood had more grey matter, thought to stave off cognitive decline, in their brains than other blood types.

Some Alzheimer's Patients Have Increased Pain Sensitivity

Some Alzheimer's Patients Have Increased Pain Sensitivity

Patients with mild-to-moderate Alzheimer's and Parkinson's tended to experience more pain, yet those with other forms of cognitive impairment had less.

New Parkinson's Biomarker Identified Through Changes in Brain Area

New Parkinson's Biomarker Identified Through Changes in Brain Area

MRI imaging indicates that in Parkinson's patients, the brain's substania nigra changes as the disease progresses.

History of Depression May Raise Parkinson's Risk

History of Depression May Raise Parkinson's Risk

Only 1.1% of those with depression eventually developed Parkinson's, compared with 0.4% without a history of depression.

Parkinson's Protein May Trigger Brain Inflammation

Parkinson's Protein May Trigger Brain Inflammation

However, the blood pressure medication candesartan and an experimental drug both reduced the immune response.

Mediterranean Diet Plus Nuts Improves Brain Function With Age

Mediterranean Diet Plus Nuts Improves Brain Function With Age

Adding olive oil or nuts to a Mediterranean diet improved memory and cognition better than those on a low-fat diet.

Healthy Eating Lowers Risk of Cognitive Decline

Healthy Eating Lowers Risk of Cognitive Decline

Study involving more than 28,000 people in 40 countries finds those who scored highest on "healthy eating" index less likely to have memory decline.

Heart Implant Linked to Decline in Cognitive Function

Heart Implant Linked to Decline in Cognitive Function

Almost 30% of patients who received a left ventricular assist device had significant decline in cognitive functioning a year after getting implant.

Challenging Jobs May Protect Against Memory Loss

Challenging Jobs May Protect Against Memory Loss

Seniors who worked at jobs that involved challenging tasks had a slower rate of memory loss and cognitive decline.

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