Neurocognitive Disorders Archive
New data were presented at the IAS Conference, pertaining to predictive factors and cognitive screening for HIV-associated neurocognitive disorders.
This study suggests a link between high reward receptor responses in the striatal cortex and expression of pain complaints 2 years later.
Head impacts in soccer are independently associated with moderate to very severe central nervous system (CNS) symptoms.
More specific biomarkers will be needed to differentiate between atypical parkinsonian disorders.
These preliminary findings suggest that combined treatment with MAAT and methylphenidate can improve attention, episodic and working memory, and executive functioning following traumatic brain injury.
Better management of cardiovascular risk factors and higher levels of education may have contributed to this improvement.
The American Heart Association issues a scientific statement on the possible link between chronic arterial hypertension and cognitive impairment.
Levodopa pill can wear off, but a powdered version can help patients during off periods.
In 2016, an estimated 5.4 million US adults have Alzheimer disease.
Serum ghrelin levels may serve as a biomarker of executive function in patients with type 2 diabetes.
Most aging humans will develop some degree of decline in cognitive capacity.
The study suggests that statins may serve a greater purpose beyond control of lipids and cardiovascular events.
Researchers saw a beneficial effect in tests examining frontal lobe function and improvement in memory.
Dopaminergic Control of Striatal Cholinergic Interneurons May Cause Antipsychotic-Associated Parkinsonism
Research examines the underlying mechanisms for the disabling adverse effects associated with antipsychotic medications.
Distinguishing between psychiatric disorders and AD is crucial because of the differing prognosis and management of the two.
To date, there are no validated biomarkers to independently assess Parkinson Disease diagnosis and prognosis, or to measure disease severity.
Declining smoking rates could be associated with higher incidence of parkinsonism and PD.
Neurologic symptoms resolved after 1 month of antiviral treatment in 90% of study participants.
The drug is the first of its kind to address PD psychosis without having an ill effect on motor symptoms.
Athletes presenting with psychosomatic symptoms before a concussion may have a longer recovery period.
Declines in processing sleep and episodic memory were observed in those with low levels of activity.
The researchers observed between-group differences between real and sham acupuncture treatment.
Unclear whether the medications or the disease are the key factor; study only shows an association.
Research found an association, but no cause-and-effect relationship, between rosacea and Parkinson's.
Those with cognitive difficulties struggle to follow conversations or recall words.
Researchers sought to understand sex differences in verbal memory deficits and its relationship to hippocampal volume.
Paroxetine use improved cognitive impairment and reduced inflammation in HIV patients.
Metabolic syndrome was linked to increased incidence of mild cognitive impairment and progression to dementia.
Poorer CV fitness, greater exercise BP in midlife linked to smaller brain volume 20 years later.
Avoiding the common prescription and OTC gastrointestinal drugs may help prevent development of dementia.
Of adults aged 45 years and older reporting recent check-up, only 25.2% reported SMCs.
Increasing weight loss, BMI from midlife to late life may be marker for mild cognitive impairment.
For adults, mild cognitive issues that may develop over time are unrelated, researchers say.
However, results should be interpreted with attention to the study details, Mayo doc says.
Men with higher urate concentrations had a lower future risk of developing Parkinson's, suggesting that urate could have a protective factor.
Those who took rivastigmine in study were 45% less likely to have an accident.
Results from a recent multiple sclerosis trial with simvastatin indicate that it could be an effective treatment to slow progression of Parkinson's.
Lumos Labs, the creators of Lumosity, will pay $2 million to settle Federal Trade Commission charges.
Exercise-induced alterations in microbiota produce extensive neural and metabolic benefits.
There was no difference in cognition between Parkinson's patients taking a high and lower level of anticholinergic medications.
Patients with hepatitis C were 2.5 times more likely to develop Parkinson's before adjustments.
In a mouse model of Parkinson's, LBT-3727 was able to protect dopamine-producing cells.
After performing brain autopsies, researchers found pesticide residue in 90% of the participants.
Study may be the first evidence associating white matter abnormalities with reduced cognitive ability in children with early-onset epilepsy.
Based on visual responses of fruit flies, the ones with mutations toward Parkinson's had increase neuronal activity to stimulation.
Researchers identified two genes with potentially damaging genetic variants that could affect familial Parkinson's susceptibility.
The test uses a device that produces visual flickers to measure visual processing speed.
The new criteria emphasizes that Parkinson's is more than a motor disorder, emphasizing the early stages of the disease.
In study involving female twins, the sibling with the greater leg strength maintained her mental abilities better and had fewer age-related brain changes.
Inconsistent conclusion among studies looking at the association may be the result of retrospective assessments, definition of drinkers.
Mice that engaged in regular exercise saw less structural deterioration in the brain.
The researchers observed significant increases in gait speed, step length, floor reaction force, and cadence after acupuncture.
Scientists may have discovered a way to stop the formation of Lewy bodies, protein clumps found in the brains of those with Parkinson's.
Nilotinib (Tasigna) improved cognition and motor skills in patients with Parkinson's and Lewy body dementia.
The drug, RGFP966, is thought to make neurons more plastic, allowing them to make connections and thus changes that can enhance memory.
Action-oriented video games may help to improve cognitive function.
PDP patients treated with antipsychotics were four times as likely to died following three to six months of treatment than those not on the meds.
A non-threatening virus was delivered a genetic "switch" to cholinergic neurons in the brains of rat cells, followed by a drug to activate the "switch."
Parkinson's disease patients who received transcranial direct current stimulation saw a 25% improvement in motor symptoms.
Highest risk of subsequent Parkinson's was with asthma patients with more frequent hospital admissions.
Discovery could potentially lead to new treatments.
Compounds that inhibit the enzymes that cause the deposits are being tested as obesity treatments, but could have potential for Alzheimer's too.
Researchers say eating a more healthy diet may have more of an effect.
Biomarker may provide a way of detecting patients at risk of developing Alzheimer's at earlier stage than currently available.
Higher salivary cortisol levels in the evening was tied to lower brain volume and worse cognitive function.
In people with PD, high neurofilament light chain protein, low Aβ1-42, and high heart fatty acid-binding protein was associate with PD dementia.
Participation in strenuous physical activity correlated with smaller T2 lesion volumes and lower annualized relapse rate.
The FDA has accepted Teva's New Drug Application for deutetrabenazine to treat chorea associated with Huntington's disease.
Sleeping on one's side may be the best position for removal of waste from the brain, based on study in rodents.
It's not clear whether the brain deposits are harmful or have long-term health effects.
Patients who used glitazones were 28% less likely to be diagnosed with Parkinson's than those who never took one of the medications.
Rats with Parkinson's symptoms given chloroquine and amodiaquine, two popular antimalaria drugs, showed improvements in movement.
Stopping the buildup of beta-2-microglobulin (B2M) protein in the blood and brain may prevent or reverse memory problems.
Researchers find narcolepsy symptoms the most severe in patients taking dopamine agonists, so clinicians should be cautious in using them.
Improved communication and information between Parkinson's researchers and patients could lead to greater success in Parkinson's clinical trials.
Parkinson's patients who took any antipsychotic were more than twice as likely to die within 180 days than those not on one.
Juice from a variety of New Zealand blackcurrants led to improvements in mood, attention and mental fatigue in patients.
Mice given diets high in sugar and fat demonstrated diminished cognitive functioning compared with mice on regular diets.
Apomorphine that is injected was shown to work faster than oral levodopa to treat morning akinesia in Parkinson's disease patients.
Parkinson's disease patients who were given the inhaled levodopa showed rapid improvement in motor symptoms and a reduction in "off" hours daily.
Taiwanese study shows that Parkinson's disease was associated with a higher risk of 16 types of cancer, including lung and brain tumors.
Men who consumed more trans fats daily were able to remember fewer words in a memory test than others who ate fewer such fats.
The Brio Neurostimulation System continuously delivers low-intensity electrical pulses to the brain to treat Parkinson's and essential tremor.
Opicapone, a COMT inhibitor added to levodopa, reduced absolute off-time by two hours compared to placebo in Parkinson's patients.
More than one-third of early Parkinson's patients, whether or not taking medication, reported severe fatigue, memory difficulties and urinary urgency.
Individuals with type 'O' blood had more grey matter, thought to stave off cognitive decline, in their brains than other blood types.
Patients with mild-to-moderate Alzheimer's and Parkinson's tended to experience more pain, yet those with other forms of cognitive impairment had less.
MRI imaging indicates that in Parkinson's patients, the brain's substania nigra changes as the disease progresses.
Only 1.1% of those with depression eventually developed Parkinson's, compared with 0.4% without a history of depression.
However, the blood pressure medication candesartan and an experimental drug both reduced the immune response.
Adding olive oil or nuts to a Mediterranean diet improved memory and cognition better than those on a low-fat diet.
Study involving more than 28,000 people in 40 countries finds those who scored highest on "healthy eating" index less likely to have memory decline.
Almost 30% of patients who received a left ventricular assist device had significant decline in cognitive functioning a year after getting implant.
Seniors who worked at jobs that involved challenging tasks had a slower rate of memory loss and cognitive decline.
The Movement Disorders Journal app can document slowness, tremor, and gait/balance and export data to clinicians.
The Oculus Rift headset, normally used to provide a 3D gaming experience, lets clinicians experience hallucinations and delusions.
Patients who were switched from oral carbidopa-levodopa to CLES (Duopa) showed improvements in motor system functioning.
However, treatment with a CPAP machine in patients with sleep apnea delayed onset of cognitive impairment.
Parkinson's patients who learned the Argentine tango saw improvement in balance and functional mobility.
RNA signatures identified that correlate with mutations in the LRRK2 gene, a known risk factor for Parkinson's.
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