Sex Change Hormones May Alter Depression Risk
the Psychiatry Advisor take:
Individuals that undergo a sex change operation may have an increase risk of a depression as a result of the hormone treatments given during gender reassignment.
The study conducted by Rupert Lanzenberger, MD, Medical University of Vienna, Austria, and colleagues sought to evaluate depression in people going through gender reassignment surgery. Hormone treatments significantly alter the recipient’s physical appearance to match that of the opposite sex, and include changes in voice, muscle tone, complexion and body shape.
Receiving the male hormone testosterone in female-to-male transsexuals raised brain levels of SERT, the protein that transports the chemical messenger serotonin into nerve cells, the researchers reported in the journal Biological Chemistry. However, male-to-female transsexuals who received a testosterone blocker and the female hormone estrogen showed decreased levels of SERT.
SERT plays an important function in the treatment of mood and anxiety disorders as many antidepressants work to block its activity by inhibiting serotonin uptake. And some studies have indicated that high levels of SERT may boost resilience to stress and mitigate risk for mood disorders.
The findings seem to suggest that when people switch from female to male, their biology changes in a way that is consistent with a reduced risk for mood and anxiety disorders, but the reverse happens when males switch to females.
When people switch from female to male, their biology changes in a way that is consistent with a reduced risk for mood and anxiety disorders.
Hormonal treatments given as part of the sex reassignment process alters an individual's brain chemistry, increasing the risk of depression in male-to-female transsexuals and lowering the risk in female-to-males, according to a new study published in the journal Biological Psychiatry. The process aligns the transsexual's risk of depression with the established risk of their desired gender.
Researchers and doctors have long known and documented the bodily effects of gender reassignment hormonal treatments. These hormones greatly alter the secondary sexual characteristics of the adult body, shifting a recipient's physical appearance to that of the opposite sex. Changes occur involving hair growth and texture, voice, muscle tone, complexion, and overall body shape.
Psychiatry Advisor Articles
- Early Detection Markers of Alzheimer's Disease Possibly Identified
- Transcranial Direct Current Stimulation Inferior to Escitalopram
- Illicit Cannabis Use Among Adults Up Due to Medical Marijuana Laws
- Memory Training Opportunities Exist for Patients With Schizophrenia
- APA: Medical Discrimination Based on Size Psychologically, Physically Harms Patients
- Criteria For Identification of Smartphone Addiction
- Bipolar Disorder: Childhood Trauma Modulates Impact on Amygdala, Hippocampus
- Psychiatric Evaluations: Questions on Suicide Need to Be Rephrased
- Subsequent Suicide Attempts May Be Reduced by Emergency Department Interventions
- Elevated Levels of Childhood Adversity in Patients with Fibromyalgia and Chronic Widespread Pain
- Prescription Opioid Misuse Remains a Persistent Problem
- Revised Treatment Guidelines for Pediatric Acute Onset Neuropsychiatric Syndrome
- Long-term Response to Prophylactic Mood Stabilizers in Bipolar Disorder
- Medically Supervised Withdrawal, an Option for Pregnant Women Addicted to Opioids
- Navigating the Thin Line Between Identification & Intimacy With Patients