Dysfunction in Brain's Attention Network May Increase Schizophrenia, Bipolar Risk
the Psychiatry Advisor take:
A new study suggests that brain network interactions between regions that support attention are dysfunctional in children and adolescents at genetic risk for developing schizophrenia and bipolar disorder.
The study is significant because the estimated lifetime incidence of schizophrenia or bipolar disorder in the groups studied is approximately 10 to 20 times what is generally observed.
"We believe that genetic risk may confer vulnerability for dysfunctional brain network communication. This abnormal network communication in turn might amplify risk for psychiatric illnesses. By identifying markers of network dysfunction we believe we can elucidate these mechanisms of risk. This knowledge may in turn increase focus on possible premeditative intervention strategies," Vaibhav Diwadkar, associate professor of psychiatry and behavioral neurosciences at Wayne State University, said.
The study involved 46 children and adolescents aged 8 to 20 years, half of whom were at genetic risk for schizophrenia or bipolar disorder due to having one or both parents with either illness. Participants were asked to complete tasks that required sustained attention while undergoing 20 minutes of functional magnetic resonance imaging (fMRI).
Among participants in the genetic risk group, interactions between the dorsal anterior cingulate and the basal ganglia were highly dysfunctional compared with the control group, the researchers found.
"Emergent patterns of regional dysfunction and dysconnection in cortical–striatal pathways may provide functional biological signatures in the adolescent risk-state for psychiatric illness," they wrote.
Brain networks supporting attention do not communicate correctly in children at risk for bipolar dis
Attention deficits are central to psychiatric disorders such as schizophrenia or bipolar disorder, and are thought to precede the presentation of the illnesses.
Study findings published in Frontiers in Psychiatry suggest that the brain network interactions between regions that support attention are dysfunctional in children and adolescents at genetic risk for developing schizophrenia and bipolar disorder.
Sign Up for Free e-newsletters
Psychiatry Advisor Articles
- Efficacy of Drugs for Psychosis, Relapse Prevention for Bipolar Depression, Mania
- Cost-Effectiveness of Atomoxetine for Treating Children with ADHD
- No Evidence of Cognitive Impairment With Lisdexamfetamine Dimesylate in ADHD
- Differential Testosterone Levels in Men, Women With Schizophrenia
- Plasma Autoantibodies Possible Biomarker for Schizophrenia
- Substance-Induced Psychosis Associated With Development of Schizophrenia, Bipolar Disorder
- Neuropsychiatric Events May Be Linked to Nitrated Nucleosome Levels in Lupus
- New APA Guideline Recommendation for Treatment of Alcohol Use Disorder
- Reducing PTSD Symptoms: Propranolol Before Reactivation Therapy
- Cannabis Use Associated With Subsequent Psychotic Experiences in Adolescents
- Intervention Improves Quality of Life, Agitation in Nursing Home Patients With Dementia
- Cognitive Enhancement Therapy Beneficial for Neurocognitive Function in Autism
- The Crisis of Physician Suicides: Past and Present
- Affective Temperaments in Bipolar Have a Significant Impact on Functional, Clinical Outcomes of Mania
- Ketamine: A Promising Agent for Managing Treatment-Resistant Depression