Mood Disorders Archive

Epigenetic Modifications Associated with Low SES May Influence Depression Risk

Epigenetic Modifications Associated with Low SES May Influence Depression Risk

Socioeconomic status was the only environmental stressor that predicted an increase in SLC6A4 proximal promoter methylation.

Meta-Analysis Indicates Antidepressants Ineffective in Children, Teens

Meta-Analysis Indicates Antidepressants Ineffective in Children, Teens

A systematic review showed that most antidepressants are ineffective, and sometimes risky, for children and teens.

Genetic Variants May Account for Poorer ECT Response in Treatment-Resistant Patients

Genetic Variants May Account for Poorer ECT Response in Treatment-Resistant Patients

Polymorphisms of the GRIK4 gene modulate the response to electroconvulsive therapy.

Abnormal Habenula Activation Profile in Major Depression

Abnormal Habenula Activation Profile in Major Depression

Aversive conditioned stimulus-elicited habenula response decreased in individuals diagnosed with major depression.

Stress-Induced Depressive-Like Symptoms Controlled by Networks of Genes

Stress-Induced Depressive-Like Symptoms Controlled by Networks of Genes

Manipulating gene networks across distinct brain regions in mice affects susceptibility or resilience to depression-like behavior.

Brain Cortical Thinning and Surface Area Reductions in Major Depressive Disorder

Brain Cortical Thinning and Surface Area Reductions in Major Depressive Disorder

Age-dependent structural brain abnormalities identified in adolescents and adults with major depressive disorder.

Prolonged Antidepressant Effects of Whole-body Hyperthermia Treatment

Prolonged Antidepressant Effects of Whole-body Hyperthermia Treatment

A single session of whole-body hyperthermia treatment reduced depressive symptoms.

Patients on Lithium Are Significantly Less Likely to Harm Themselves

Patients on Lithium Are Significantly Less Likely to Harm Themselves

Patients with bipolar disorder taking lithium have lower rates of self-injury.

Depressive Symptoms in Caregivers of Ventilator-Dependent ICU Patients

Depressive Symptoms in Caregivers of Ventilator-Dependent ICU Patients

Study reports that most caregivers of ICU patients on ventilators describe high levels of depressive symptoms.

Homosexual Status as a Contributing Factor to Depression and Anxiety in Young Men

Homosexual Status as a Contributing Factor to Depression and Anxiety in Young Men

Research found increased incidence of mental health issues in young gay and bisexual men.

Restricting Calories Improves Health and Mood in Non-Obese

Restricting Calories Improves Health and Mood in Non-Obese

Those in the calorie cutting group said their sleep and relationships also improved.

Depression, Stress May Affect HPV-related Health Problems

Depression, Stress May Affect HPV-related Health Problems

Planned future studies will examine whether cervical inflammatory markers are associated with stress.

Importance of Perceived Control in Treating Pain, Depression

Importance of Perceived Control in Treating Pain, Depression

Clinicians should focus on treating patients' pain and psychological conditions together.

Increasing Depressive Symptoms Associated with Dementia Risk

Increasing Depressive Symptoms Associated with Dementia Risk

The trajectory of increasing depressive symptoms was associated with a higher risk of dementia.

Mindfulness-Based Cognitive Behavioral Therapy Curbs Depression Relapse

Mindfulness-Based Cognitive Behavioral Therapy Curbs Depression Relapse

At least 50% of patients who recover from an initial episode of major depressive disorder experience at least 1 subsequent episode.

Antidepressant Bupropion Linked To Less Weight Gain

Antidepressant Bupropion Linked To Less Weight Gain

Having more information on the long-term impact of antidepressants on weight could reduce the risk of weight-related morbidity for a large population of adults with depression.

Depression May Affect Migraine Treatment Response

Depression May Affect Migraine Treatment Response

Depression is one of many factors that can predict an inadequate treatment response in patients with episodic migraine.

Diabetes Weight Loss Diets Improve Mood, Depression

Diabetes Weight Loss Diets Improve Mood, Depression

How does a high carbohydrate or low carbohydrate weight loss diet affect depression in type 2 diabetes?

Increased Incidence of Comorbid Bipolar Disorder and Asthma

Increased Incidence of Comorbid Bipolar Disorder and Asthma

Research identifies high comorbidity rates between these 2 distinct diseases with underlying inflammation dysfunction.

Theory of Mind Decoding Impairment Associated With Mania in Bipolar Disorder

Theory of Mind Decoding Impairment Associated With Mania in Bipolar Disorder

Theory of Mind refers to the ability to assign mental states to oneself and others based on social cues such as tone of voice and facial expressions.

Can Effectively Treating Depression Reduce Cardiovascular Risk?

Can Effectively Treating Depression Reduce Cardiovascular Risk?

The risk of cardiovascular disease as a person's depression improves or worsens has largely remained unknown.

Ankylosing Spondylitis Increases Risk of Depressive Disorders

Ankylosing Spondylitis Increases Risk of Depressive Disorders

Research has found that patients with AS have an increased risk of developing certain depressive disorders following their diagnosis.

Oxytocin Predicts Postpartum Depression Symptoms

Oxytocin Predicts Postpartum Depression Symptoms

Oxytocin levels predicted the severity of postpartum depression symptoms among women with a history of depression.

SSRIs Found Not To Increase Risk of Cardiac Events in Depression

SSRIs Found Not To Increase Risk of Cardiac Events in Depression

Neither a specific antidepressant class nor individual drugs had any influence on the risk of stroke or transient ischemic attack over all of follow-up.

Coffee, Caffeine May Be Linked With Decreased Depression Risk

Coffee, Caffeine May Be Linked With Decreased Depression Risk

Although researchers are not certain about the mechanisms driving the link between depression and coffee or caffeine consumption, several potential explanations have emerged.

Ketamine May Provide Lasting Relief From Depression

Ketamine May Provide Lasting Relief From Depression

Treatment gives infusions of ketamine no more than once per week.

Obesity Linked to Greater Depression Odds in College-Educated Women

Obesity Linked to Greater Depression Odds in College-Educated Women

Modestly obese women who were educated were almost twice as likely to have depression than their normal-weight peers.

Depression Risk Elevated in TBI Patients with High Cholesterol

Depression Risk Elevated in TBI Patients with High Cholesterol

Study suggests statins may play a role in the development of new-onset depression.

Genetic Discovery Could Lead to Development of New Bipolar Meds

Genetic Discovery Could Lead to Development of New Bipolar Meds

Abnormal variations in the gene PDE10A19 might impact signaling of a messaging pathway responsible for learning, memory.

Better Diet, Exercise Can Lead to Behavioral Improvements

Better Diet, Exercise Can Lead to Behavioral Improvements

Feasible opportunities for healthy diet and activity linked to intentions, behaviors, and BMI.

Psychotic and Bipolar Disorder Most Predict Suicide After Prior Self-Harm

Psychotic and Bipolar Disorder Most Predict Suicide After Prior Self-Harm

Individuals with bipolar disorder or psychosis were 6 times more likely to die by suicide after prior self-harm.

Pediatricians Miss Opportunities for Maternal Depression Screenings

Pediatricians Miss Opportunities for Maternal Depression Screenings

Only 44% of pediatricians ask mothers during child visits about maternal depression.

Botox Helps Ease Anxiety, Depression in Patients With Skin Condition

Botox Helps Ease Anxiety, Depression in Patients With Skin Condition

Reductions in sweat-related health problems, anxiety and depression, symptom severity.

Significant Treatment Gaps Exist for Depression Patients

Significant Treatment Gaps Exist for Depression Patients

Results from a new survey suggest that significant gaps exist in the treatment for adults in the US with major depressive disorder.

Can New Class of Mood Disorder Drugs Also Treat Chronic Pain?

Can New Class of Mood Disorder Drugs Also Treat Chronic Pain?

New research suggests that a group of drugs being developed for mood disorders could also relieve chronic pain.

Antidepressants May Double Risk of Suicide, Aggression In Adolescents

Antidepressants May Double Risk of Suicide, Aggression In Adolescents

The odds ratios for children and adolescents were 2.39 for suicidality, 2.79 for aggression, and 2.15 for akathisia.

SSRI Use Associated With Higher Risk of Postpartum Hemorrhage

SSRI Use Associated With Higher Risk of Postpartum Hemorrhage

Risk up with exposure to serotonin-norepinephrine reuptake inhibitors in late pregnancy.

CBT, Medication Have Same Efficacy for Treating Depression

CBT, Medication Have Same Efficacy for Treating Depression

For adults, similar efficacy for cognitive behavioral therapy and antidepressants.

Stress Hormone Lowering Drug Doesn't Benefit Depression

Stress Hormone Lowering Drug Doesn't Benefit Depression

New research questions the efficacy of metyrapone as an adjunctive treatment for treatment-resistant depression.

Depression May Increase Risk of Heart Disease, Stroke In Older Adults

Depression May Increase Risk of Heart Disease, Stroke In Older Adults

Adults 65 years and older who had high levels of depression at least one time had a greater risk of experiencing heart disease or stroke.

Mood Stabilizer May Inhibit Coagulation

Mood Stabilizer May Inhibit Coagulation

Carbamazepine co-treatment linked to subtherapeutic anticoagulative effect of warfarin.

Review Explores Potential Harms of Antidepressant Treatment

Review Explores Potential Harms of Antidepressant Treatment

No significant risks were found in adults; the risk of suicidality and aggression doubled in children and teens.

Depressive Symptoms Associated with Coronary Artery Calcium

Depressive Symptoms Associated with Coronary Artery Calcium

Depressive symptoms have a gender-specific, cross-sectional association with CAC but no statistically significant associations with CAC progression.

USPSTF Presents Updated Guidelines For Depression Screening In Adults

USPSTF Presents Updated Guidelines For Depression Screening In Adults

In an update of their 2009 guidelines, the US Preventive Services Task Force has provided updated recommendations for screening for depression in adults.

Paroxetine Use in Pregnancy Linked to Defects

Paroxetine Use in Pregnancy Linked to Defects

Increased risk of any major congenital malformations, major cardiac malformations.

Later Menopause Linked to Reduced Postmenopausal Depression Risk

Later Menopause Linked to Reduced Postmenopausal Depression Risk

For every two years older women were at menopause, they had 2% reduced odds of later depression based on 13 of the studies.

Mood Induction Significantly Impacts IL-18 in Depressed Patients

Mood Induction Significantly Impacts IL-18 in Depressed Patients

Changes in IL-18 levels were more pronounced in depressed volunteers.

Scientists a Step Closer to Treating Depression with Ketamine

Scientists a Step Closer to Treating Depression with Ketamine

The activation of a brain pathway mimicked an antidepressant-like response to ketamine in mice.

Novel Antidepressant Shows Promise in Phase 1

Novel Antidepressant Shows Promise in Phase 1

NSI-189 has demonstrated the ability to produce new brain cells and has been effective in early stage trials.

Chronic Inflammation Can Worsen Depression

Chronic Inflammation Can Worsen Depression

In those suffering from clinical depression, two inflammatory markers, CRP and IL-6, were found to be elevated by up to 50%.

Antidepressant Treatment May Increase Mania, Bipolar Risk

Antidepressant Treatment May Increase Mania, Bipolar Risk

Significant association seen in SSRIs and venlafaxine in unipolar depression.

Gene Variant Linked to Psychotic Symptoms of Bipolar Disorder

Gene Variant Linked to Psychotic Symptoms of Bipolar Disorder

A team of researchers have linked a genetic variant of the SNX7 gene with both elevated levels of kynurenic acid and the disease symptoms of bipolar disorder.

'Rescued' Drug Could Be Safer Treatment for Bipolar Disorder

'Rescued' Drug Could Be Safer Treatment for Bipolar Disorder

An abandoned drug for stroke treatment may provide a safer treatment than lithium in treating bipolar disorder.

Antidepressant Exposure in Pregnancy Increases Child's Autism Risk

Antidepressant Exposure in Pregnancy Increases Child's Autism Risk

Women who took antidepressants during the second and/or third trimester were 87% more likely to have a child diagnosed with autism than those who did not take antidepressants during pregnancy.

No Difference Between Antidepressants, CBT for Severe Depression

No Difference Between Antidepressants, CBT for Severe Depression

There was no statistically significant differences in effectiveness between second-generation antidepressants and CBT for response or remission.

Depression in Interns and Residents on the Rise

Depression in Interns and Residents on the Rise

Almost 30% of medical residents reported having depression or depressive symptoms.

Proteins Could be Potential Bipolar Disorder Biomarkers

Proteins Could be Potential Bipolar Disorder Biomarkers

There was a significant difference in six proteins in those with bipolar I depression compared to the control group.

Antidepressants May Thwart Brain Inflammation

Antidepressants May Thwart Brain Inflammation

Depressed patients who took the SSRI escitalopram also saw declines in two neurotoxic compounds associated with inflammation.

FDA Committee Looks Unfavorably on Antidepressant Gepirone

FDA Committee Looks Unfavorably on Antidepressant Gepirone

The FDA's Psychopharmacologic Drugs Advisory Committee voted 9-4 that gepirone did not demonstrate substantial effectiveness.

Depression Linked to Hospitalization for Preventable Illnesses

Depression Linked to Hospitalization for Preventable Illnesses

Subjects with depression were 2.35 times more likely to be hospitalized for a preventable illness than those without depression.

Black Box Warning Impacts SSRI Dosing in Youths

Black Box Warning Impacts SSRI Dosing in Youths

After the addition of the black box warning on suicidality in 2004, clinicians were more likely to start adolescents on a lower SSRI dose.

Market for Antidepressants, Anti-Anxiolytics to Decline

Market for Antidepressants, Anti-Anxiolytics to Decline

The global market for anxiety treatments and antidepressants will decline at a compound annual growth rate of 1.25% between 2014 and 2020.

Is the Fourth Time the Charm for This Antidepressant?

Is the Fourth Time the Charm for This Antidepressant?

An FDA advisory committee is considering the fate of gepirone, which was rejected by the agency in 2002, 2004, and 2007.

Discrimination Impacts Depression, Prosocial Behavior in Latino Youth

Discrimination Impacts Depression, Prosocial Behavior in Latino Youth

Discrimination can create a cycle of depression and fewer prosocial behaviors.

Omega-3 Link to Bipolar Disorder Opens Door for New Treatments

Omega-3 Link to Bipolar Disorder Opens Door for New Treatments

Lower levels of certain omega-3 acids were associated with more bipolar symptoms, such as mania and suicidal ideation.

Loneliness Linked to Brain Inflammation, Premature Death

Loneliness Linked to Brain Inflammation, Premature Death

Loneliness can negatively impact cells of the immune system, making one more susceptible to physical illnesses.

Inflammation Related to Muted Pleasure Feelings in Depression

Inflammation Related to Muted Pleasure Feelings in Depression

Depressed patients with high levels of an inflammatory marker in their blood were particularly susceptible to anhedonia.

Bright Light Therapy Not Just For Seasonal Affective Disorder

Bright Light Therapy Not Just For Seasonal Affective Disorder

Bright light treatment, a standard therapy for SAD, may also be useful for nonseasonal depression.

Daughters of Older Mothers May Have Higher Risk of Depression

Daughters of Older Mothers May Have Higher Risk of Depression

The age difference between older mothers and daughters or older mothers' health problems may be to blame.

Depression in African-Americans Boosts Coronary Risks

Depression in African-Americans Boosts Coronary Risks

African-Americans who exhibit symptoms of major depression have twice the risk of stroke and coronary heart disease.

Online CBT May Offer Little To No Benefit For Depression

Online CBT May Offer Little To No Benefit For Depression

The researchers note the poor outcomes of online CBT were primarily from low engagement and low adherence to treatment.

Internet-Based CBT Lowers Suicidal Ideation in Medical Interns

Internet-Based CBT Lowers Suicidal Ideation in Medical Interns

Interns who participated in Web-based CBT were less likely to endorse suicidal ideation compared with those assigned to attention-control group.

CBT Better Than Light Therapy for Seasonal Affective Disorder

CBT Better Than Light Therapy for Seasonal Affective Disorder

Light therapy may be better when it comes to acute episodes of SAD, but CBT may be more effective to prevent relapse.

No Proof Omega-3 Supplements Work For Depression

No Proof Omega-3 Supplements Work For Depression

Studies have found only small improvements in treating depression with Omega-3s and have been of low-quality.

Genetic Risk Marker Found for Depression

Genetic Risk Marker Found for Depression

The APOE ε4 allele correctly predicted future depression, even after excluding people who later developed dementia.

Depressive Thoughts Can Interfere With Memory

Depressive Thoughts Can Interfere With Memory

Negative thoughts last longer in people with depression and interfere with their memory.

Online CBT Beneficial for Depression, Anxiety

Online CBT Beneficial for Depression, Anxiety

Patients who participated in CBT via the internet had equal or better outcomes compared with those who participated in traditional in-person CBT.

Diminished Reward Processing Linked to Adolescent Depression

Diminished Reward Processing Linked to Adolescent Depression

Early life stress in some people may alter the brain's ability to experience enthusiasm or pleasure.

Brain Cells May Predict Bipolar Patients' Response to Lithium

Brain Cells May Predict Bipolar Patients' Response to Lithium

Brain cells from lithium responder patients showed weakened excitability after being treated with lithium.

Complete Resolution of Depressive Symptoms Drops Relapse Risk

Complete Resolution of Depressive Symptoms Drops Relapse Risk

Once depressed patients who were symptom free didn't relapse for four times longer than those who had lingering symptoms.

Study Questions Reliance on DSM for Depression Diagnosis

Study Questions Reliance on DSM for Depression Diagnosis

Depression is a complex system of interacting symptoms, some of which may be far more important than others, researchers say.

Faulty Brain Cells Implicated As Possible Depression Cause

Faulty Brain Cells Implicated As Possible Depression Cause

Malfunctioning microglia can cause depression, but drugs that restore the normal functioning of them can be as effective as antidepressants.

Increasing Antidepressant Doses May Not Produce More Effective Results

While increasing antidepressant doses may not be wrong, there isn't evidence supporting that it increases effectiveness.

Job Burnout Linked to Depression

Job Burnout Linked to Depression

Eighty-six percent of teachers polled who said they felt burned out by their job met criteria for depression.

Number of Pregnant Depressed Women May Be Underestimated

Number of Pregnant Depressed Women May Be Underestimated

Study from the UK finds finds that 30% of pregnant women had five or more characteristics of depression.

Many Mental Health Apps Are Not Evidence Backed

Many Mental Health Apps Are Not Evidence Backed

85% of mental health apps recommended by the UK's National Health Service have no evidence that they work.

After Heart Attack, Exercise, Quitting Smoking Eases Depression

After Heart Attack, Exercise, Quitting Smoking Eases Depression

Smoking cessation demonstrated the strongest association with improving depression after heart attack.

Lithium Safe and Effective For Children With Bipolar Disorder

Lithium Safe and Effective For Children With Bipolar Disorder

Children on lithium showed much more significant improvement in their symptoms over the study period compared to placebo patients.

Sex Change Hormones May Alter Depression Risk

Sex Change Hormones May Alter Depression Risk

When people switch from female to male, their biology changes in a way that is consistent with a reduced risk for mood and anxiety disorders.

Many Workers With Depression Don't Seek Treatment

Many Workers With Depression Don't Seek Treatment

More than 50% of workers who said they were experiencing depressive symptoms said they didn't feel the need to seek help.

Bariatric Surgery May Boost Suicide Risk

Bariatric Surgery May Boost Suicide Risk

A substitution of substance misuse for food and increased stress may affect the likelihood of depression and suicidal behavior.

MRI Scans Could Predict Likelihood of Depression Relapse

MRI Scans Could Predict Likelihood of Depression Relapse

Patients who went on to have another episode of depression had a higher connectedness between two parts of the brain.

Quality of Sibling Relationships Impacts Depression, Risky Behaviors

Quality of Sibling Relationships Impacts Depression, Risky Behaviors

Siblings with positive relationships showed fewer risky behaviors, whereas siblings with negative relationships engaged in more risky behaviors.

Efficacy of Psychotherapy for Depression 'Overstated'

Efficacy of Psychotherapy for Depression 'Overstated'

Researchers discovered unpublished studies on psychotherapy that found the benefit of it not as great as thought.

Deep Brain Stimulation May Trigger 'Depression Switch'

Deep Brain Stimulation May Trigger 'Depression Switch'

Unique connectivity patterns identify potential depression switch in treatment-resistant depression.

Psoriasis May Increase Risk of Developing Depression

Psoriasis May Increase Risk of Developing Depression

The risk of depression was not different in patients with limited vs. extensive psoriasis.

Depressed Patients' Placebo Response May Predict Response to Real Therapy

Depressed Patients' Placebo Response May Predict Response to Real Therapy

How a patient being treated for depression responds to a placebo may determine how well they will respond to real antidepressant therapy.

Better Screening, Fast-Acting Meds Could Prevent Suicides

Better Screening, Fast-Acting Meds Could Prevent Suicides

A new study aims to determine whether a nasally administered version of the anesthetic esketamine can treat acutely suicidal patients.

Antipsychotic Plus Antidepressant Helps Treatment-Resistant Depression

Antipsychotic Plus Antidepressant Helps Treatment-Resistant Depression

44% of depressed participants who received the antipsychotic aripiprazole in addition to an antispychotic achieved remission.

New Methodology Could Help To Better Treat Mood Disorders

New Methodology Could Help To Better Treat Mood Disorders

The aim is to group patients based on comprehensive data profiles, rather than DSM criteria, which could improve treatment decisions.

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