Generic Name and Formulations:
Mifepristone 200mg; tabs.
Indications for MIFEPREX:
Termination of intrauterine pregnancy through 70 days gestation, in a regimen with misoprostol.
Adults and Children:
Physician must sign and return Prescriber's Agreement; patient must read and sign Patient Agreement and read Medication Guide. Day 1: mifepristone 200mg as a single oral dose. Day 2 or 3: misoprostol 800mcg buccally within 24–48hrs after mifepristone dose. Day 7–14: confirm that complete termination of pregnancy has occurred by clinical exam or ultrasonographic scan.
Ectopic pregnancy or undiagnosed adnexal mass. IUD in place. Chronic adrenal failure. Prostaglandin allergy. Hemorrhagic disorders. Inherited porphyrias. Concurrent long-term corticosteroid or anticoagulant therapy.
Risk of serious infections or bleeding. To be given only by or under the supervision of physicians who have signed and returned the Prescriber's Agreement; are able to assess gestational age of embryo and diagnose ectopic pregnancy; who have access to facilities for emergency treatment of incomplete abortion, severe bleeding, or resuscitation; and who meet requirements for storage, dose tracking, etc. Do surgical termination if mifepristone and misoprostol fail. Exclude ectopic pregnancy before treatment in patients with an IUD. Procedures to prevent rhesus immunization must be used. Hemostatic disorders. Hypocoagulability. Severe anemia. Pregnancy: treatment failure may result in fetal malformation. Nursing mothers: see full labeling.
See Contraindications. May potentiate CYP3A4 substrates. May be potentiated by ketoconazole, itraconazole, erythromycin, grapefruit juice. May be antagonized by rifampin, dexamethasone, St. John's wort, phenytoin, phenobarbital, carbamazepine.
Nausea, weakness, fever/chills, vomiting, headache, diarrhea, dizziness; uterine bleeding (may be prolonged or severe), cramping; rare: serious bacterial infections, sepsis (may be fatal).
Report serious adverse events by calling (877) 432-7596.
Psychiatry Advisor Articles
- Continuing Research, Emerging Treatments Hold Promise for Treating Anorexia Nervosa
- ACOG Update: Marijuana Use Discouraged During Pregnancy, Breastfeeding
- Asenapine Prevents Recurrence of Mood Events in Bipolar Disorder
- Depression Profiles in Patients With Type 1 Diabetes vs Type 2 Diabetes
- Purpose, Questions of Social Interaction Lead Physicians to Delay Retirement
- CBT, Acceptance Commitment Therapy Helpful for Those With Chronic Pain
- Suicidal Behavior, Thoughts Associated With Perfectionist Tendencies
- Depression Reduced by Social Belonging, Feelings of Inclusion
- Sleep Disturbance May Be Causal Factor in Psychotic Experiences
- Is Antidepressant Use in Pregnancy Tied to Psychiatric Disorders in Offspring?
- Elevated Dopamine Synthesis Capacity Observed in Both Bipolar and Schizophrenia
- SSRI Use Associated With Increased Type 2 Diabetes Risk in Young Adults
- Specialty Physicians Experiencing Lack of Income Growth
- Improved Patient-Provider Communication Needed Following Urgent Care Visits
- Cardiovascular Risk Management May Slow Neurocognitive Decline in HIV