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METOZOLV ODT
Hyperacidity, GERD, and ulcers
Nausea
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Drug Name:

METOZOLV ODT Rx

Generic Name and Formulations:
Metoclopramide (as HCl) 5mg; orally-disintegrating tabs; mint flavor.

Company:
Salix Pharmaceuticals, Inc.

Therapeutic Use:

Indications for METOZOLV ODT:

Short-term (4–12 weeks) therapy for symptomatic refractory GERD.

Adult:

Allow tablet to dissolve on tongue. 10–15mg 4 times daily 30mins before meals and at bedtime. Intermittent symptoms: up to 20mg prior to provoking situation; max 12 weeks per therapeutic course. Renal impairment: reduce dose.

Children:

Not established.

Contraindications:

When stimulation of GI motility may be dangerous (eg, obstruction, perforation, or hemorrhage). Pheochromocytoma. Epilepsy. Concomitant drugs which may cause extrapyramidal reactions (eg, antidepressants, antipsychotics, neuroleptics).

Warnings/Precautions:

Discontinue if signs/symptoms of tardive dyskinesia develop; risk increases with duration of treatment and total cumulative dose. Parkinsonism. History of depression. Hypertension. CHF. Arrhythmia. Elderly. Pregnancy (Cat.B). Nursing mothers.

Interactions:

Hypertensive crisis with MAOIs. Additive sedation with alcohol, other CNS depressants. Antagonized by anticholinergics and narcotics. Monitor insulin use; may diminish gastric and accelerate intestinal absorption of drugs or food.

Pharmacological Class:

Prokinetic.

Adverse Reactions:

Headache, nausea, vomiting, fatigue, somnolence, dizziness, extrapyramidal effects, parkinsonism, tardive dyskinesia, neuroleptic malignant syndrome, hypertension.

How Supplied:

Tabs—10 x 10 (blister packs)

Indications for METOZOLV ODT:

To relieve symptoms associated with acute and recurrent diabetic gastroparesis.

Adult:

Allow tablet to dissolve on tongue. 10mg 4 times daily 30mins before meals and at bedtime for 2–8 weeks. Renal impairment: reduce dose.

Children:

Not established.

Contraindications:

When stimulation of GI motility may be dangerous (eg, obstruction, perforation, or hemorrhage). Pheochromocytoma. Epilepsy. Concomitant drugs which may cause extrapyramidal reactions (eg, antidepressants, antipsychotics, neuroleptics).

Warnings/Precautions:

Discontinue if signs/symptoms of tardive dyskinesia develop; risk increases with duration of treatment and total cumulative dose. Parkinsonism. History of depression. Hypertension. CHF. Arrhythmia. Elderly. Pregnancy (Cat.B). Nursing mothers.

Interactions:

Hypertensive crisis with MAOIs. Additive sedation with alcohol, other CNS depressants. Antagonized by anticholinergics and narcotics. Monitor insulin use; may diminish gastric and accelerate intestinal absorption of drugs or food.

Pharmacological Class:

Antidopaminergic.

Adverse Reactions:

Headache, nausea, vomiting, fatigue, somnolence, dizziness, extrapyramidal effects, parkinsonism, tardive dyskinesia, neuroleptic malignant syndrome, hypertension.

How Supplied:

Tabs—10 x 10 (blister packs)

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