Major Depressive Disorder

Cytokine Levels May Predict SSRI Response in Children and Adolescents

Cytokine Levels May Predict SSRI Response in Children and Adolescents

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Elevated cytokine levels could help to identify children who are unlikely to respond to treatment with fluoxetine.

Depression May Accelerate Brain Aging

Depression May Accelerate Brain Aging

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Greater age-related decreases in volume of the putamen were observed in participants diagnosed with major depressive disorder compared with those of healthy controls.

Executive Dysfunction in Idiopathic Depression vs Epilepsy-associated Depression

Executive Dysfunction in Idiopathic Depression vs Epilepsy-associated Depression

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Individuals suffering from depression, as well as persons diagnosed with temporal lobe epilepsy, present with dysfunction across several cognitive domains.

Cigarette Smoking Predicts Development of Depression

Cigarette Smoking Predicts Development of Depression

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Cigarette smoking prevalence among persons with severe mental illness is approximately 3 times greater than the rate observed in the general population.

The Comorbidity of Depression in Type 2 Diabetes

The Comorbidity of Depression in Type 2 Diabetes

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It has been reported previously that symptoms of depression are associated with nonadherence to diabetes self-care.

Relationship Between Depression and Stable Angina Outcomes

Relationship Between Depression and Stable Angina Outcomes

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The strongest predictor of depression in patients with chronic stable angina was an episode of depression within the past 10 years.

Depressive Symptoms Linked to Shorter Survival With Lung Cancer

Depressive Symptoms Linked to Shorter Survival With Lung Cancer

Depression symptoms at baseline correlated with increased mortality among participants with early- but not late-stage disease.

Gene Sets Altered Across Brain Regions in Schizophrenia, Bipolar Disorder & MDD

Gene Sets Altered Across Brain Regions in Schizophrenia, Bipolar Disorder & MDD

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Until now, the majority of postmortem research that has examined functionally related gene sets has been limited to a single disorder or region of the brain.

Pupillometric Analysis For Assessment of Depression Recurrence

Pupillometric Analysis For Assessment of Depression Recurrence

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Pupillary reactivity to emotional stimuli has been investigated to provide objective information about the risk for recurrence of depressive symptoms in women.

Cognition in Depression: A Critical Domain for Health Outcomes, Measurement, and Treatment

Cognition in Depression: A Critical Domain for Health Outcomes, Measurement, and Treatment

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Dr. Roger McIntyre suggests that the clinical relevance of cognitive dysfunction for any individual patient can only be adjudicated on a case-by-case basis.

Association Between Polymorphisms in the FKBP5 Gene and MDD

Association Between Polymorphisms in the FKBP5 Gene and MDD

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It is hypothesized that multiple single nucleotide polymorphisms (SNPs) work together to influence risk of complex neuropsychiatric disorders such as depression.

Evidence for a Role of Neuropeptide Y Receptor Variant in Depression

Evidence for a Role of Neuropeptide Y Receptor Variant in Depression

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Genetic variation can increase the predisposition to major depressive disorder.

The Neuroanatomy of, and Cognitive Deficits in, Depression: A Brief Overview

The Neuroanatomy of, and Cognitive Deficits in, Depression: A Brief Overview

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Atrophy of numerous structures within the central nervous system has been observed in persons suffering from depression.

Investigating Risk Factors for Postpartum Depression

Investigating Risk Factors for Postpartum Depression

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The First Baby Study at Penn State College of Medicine includes more than 3 000 women in Pennsylvania having their first baby.

Associations Between Comorbid Cigarette, Alcohol, and Marijuana Use and Psychopathology

Associations Between Comorbid Cigarette, Alcohol, and Marijuana Use and Psychopathology

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Understanding distinct patterns of comorbid substance use may be more relevant to prevention and treatment than focusing on one individual substance.

Cognitive Function in Depression: The Role of Melancholic Features

Cognitive Function in Depression: The Role of Melancholic Features

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Individuals diagnosed with melancholic major depressive disorder presented with more severe symptoms of depression compared with persons with non-melancholic depression.

ACC Activation to Reward Predicts Response to Psychotherapy for MDD

ACC Activation to Reward Predicts Response to Psychotherapy for MDD

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Sustained anterior cingulate cortex activation during rewarding events predicted better treatment response to Behavioral Activation Treatment for Depression.

Meta-Analysis: Depression Common in Patients Discharged From ICU

Meta-Analysis: Depression Common in Patients Discharged From ICU

Risk highest among patients with psych symptoms pre-ICU/psych distress symptoms while in ICU

Psychosocial and Demographic Predictors of Depression Among Individuals With Bipolar Disorder and Schizophrenia

Psychosocial and Demographic Predictors of Depression Among Individuals With Bipolar Disorder and Schizophrenia

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Bipolar disorder and schizophrenia are characterized by significant genetic overlap, as well as significant clinical presentation overlap.

Intergenerational Transmission of Risk for Depression

Intergenerational Transmission of Risk for Depression

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Grandchildren with both a depressed parent and depressed grandparent were at highest risk for MDD.

Identifying Depression: How Accurate is the PHQ-2?

Identifying Depression: How Accurate is the PHQ-2?

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The accuracy of the PHQ-2 in identifying major depression is lower than originally thought.

Following an Episode of Mania, Adults With Bipolar Disorder at Equal Risk for Depression or Anxiety

Following an Episode of Mania, Adults With Bipolar Disorder at Equal Risk for Depression or Anxiety

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Bipolar disorder (BD) is typically characterized by recurrent episodes of mania and depression, but the connection between BD and anxiety needs to be considered.

The Long-Term Mental Health Outcomes of Adolescent Chronic Pain

The Long-Term Mental Health Outcomes of Adolescent Chronic Pain

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Adolescents who experience chronic pain have higher prevalence of anxiety and depressive symptoms in adulthood.

What Neuroimaging Can Teach us About Depression

What Neuroimaging Can Teach us About Depression

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Neuroimaging studies have shown several neurophysiological substrates for depression: An overview by Theodore Henderson, MD, PhD.

Do Adjunctive Neutraceuticals Help Relieve Depression?

Do Adjunctive Neutraceuticals Help Relieve Depression?

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Augmentation and combination approaches with pharmaceuticals are often used in clinical practice.

Updated Depression Screening Recommendations for Adults

Updated Depression Screening Recommendations for Adults

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Screening of all adults is recommended regardless of risk factors.

Peripheral Inflammatory Markers Are Associated With Psychomotor Retardation in Major Depressive Disorder

Peripheral Inflammatory Markers Are Associated With Psychomotor Retardation in Major Depressive Disorder

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Psychomotor retardation is associated with poor response to antidepressant treatment.

Pathological Grief Disorder - Diagnostic Criteria

Pathological Grief Disorder - Diagnostic Criteria

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Dr Nicola Davies explores how diagnostic recognition could facilitate the diagnosis and treatment of this serious condition.

Epigenetic Modifications Associated with Low SES May Influence Depression Risk

Epigenetic Modifications Associated with Low SES May Influence Depression Risk

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Socioeconomic status was the only environmental stressor that predicted an increase in SLC6A4 proximal promoter methylation.

Enduring Depression Linked to Increased Coronary Artery Calcification Among Women

Enduring Depression Linked to Increased Coronary Artery Calcification Among Women

Major depressive disorder is a highly disabling condition that affects nearly 15 million American adults in a given year.

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