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Leuprolide acetate
Prostate and other male cancers
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Drug Name:

Leuprolide acetate Rx

Generic Name and Formulations:
Leuprolide acetate 5mg/mL; soln for SC inj; contains benzyl alcohol.

Company:
Various generic manufacturers

Therapeutic Use:

Indications for Leuprolide acetate :

Palliative treatment of advanced prostatic carcinoma.

Adult:

1mg SC daily. Rotate inj site.

Children:

Not applicable.

Contraindications:

Women. Pregnancy (Cat.X).

Warnings/Precautions:

Metastatic vertebral lesions. Urinary obstruction. Monitor serum testosterone, PSA, acid phosphatase. Increased risk of diabetes, MI, sudden cardiac death, stroke; monitor blood glucose, HbA1c, and for signs/symptoms of CVD during therapy. Risk of QT prolongation: long-term androgen deprivation therapy, congenital long QT syndrome, electrolyte abnormalities, or CHF, and concomitant Class IA or III antiarrhythmics. Instruct patient on correct self administration.

Interactions:

Concomitant Class IA (eg, quinidine, procainamide) or Class III (eg, amiodarone, sotalol) antiarrhythmics may prolong the QT interval.

Pharmacological Class:

GnRH analogue.

Adverse Reactions:

Hot flashes/sweats, inj site reaction, initial worsening of signs/symptoms (eg, bone pain, urinary tract obstruction, hematuria), edema, GI upset, pain, cardiovascular events, CNS and antiandrogenic effects, asthenia, spinal cord compression; hyperglycemia, anaphylactoid, photosensitivity.

How Supplied:

Contact supplier.

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