Abnormal Platelet Aggregation Studies
Acquired causes of platelet dysfunction:
Ingestion of aspirin or aspirin-like compounds or NSAIDs
Impaired renal function
Exposure to cardiopulmonary bypass
Presence of a paraprotein
Congenital causes of platelet dysfunction:
Storage pool disease
Disorders of thromboxane production or action
Suggested Additional Lab Testing
Platelet aggregation studies with characteristic response patterns for the different agonists help identify Glanzmann thrombasthenia, Bernard-Soulier disease, aspirin ingestion, and defects in thromboxane production or action.
Plasma or serum BUN and creatinine and urinalysis to assess renal function should be ordered.
If aspirin ingestion is suspected but denied by patient, measurement of salicylates (metabolites of aspirin) may prove useful.
Bone marrow biopsy may be useful if myeloproliferative disease is suspected.
Serum protein electrophoresis can reveal a paraprotein. To identify platelet granule storage pool disease, assays for the granular contents of platelets can be performed, but these are complex, costly, and rarely performed.
Copyright © 2017, 2013 Decision Support in Medicine, LLC. All rights reserved.
No sponsor or advertiser has participated in, approved or paid for the content provided by Decision Support in Medicine LLC. The Licensed Content is the property of and copyrighted by DSM.
Psychiatry Advisor Articles
- Early Detection Markers of Alzheimer's Disease Possibly Identified
- Transcranial Direct Current Stimulation Inferior to Escitalopram
- Illicit Cannabis Use Among Adults Up Due to Medical Marijuana Laws
- Memory Training Opportunities Exist for Patients With Schizophrenia
- APA: Medical Discrimination Based on Size Psychologically, Physically Harms Patients
- Criteria For Identification of Smartphone Addiction
- Bipolar Disorder: Childhood Trauma Modulates Impact on Amygdala, Hippocampus
- Psychiatric Evaluations: Questions on Suicide Need to Be Rephrased
- Subsequent Suicide Attempts May Be Reduced by Emergency Department Interventions
- Elevated Levels of Childhood Adversity in Patients with Fibromyalgia and Chronic Widespread Pain
- Prescription Opioid Misuse Remains a Persistent Problem
- Revised Treatment Guidelines for Pediatric Acute Onset Neuropsychiatric Syndrome
- Long-term Response to Prophylactic Mood Stabilizers in Bipolar Disorder
- Medically Supervised Withdrawal, an Option for Pregnant Women Addicted to Opioids
- Navigating the Thin Line Between Identification & Intimacy With Patients