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IMITREX INJECTION
Migraine and headache
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Drug Name:

IMITREX INJECTION Rx

Generic Name and Formulations:
Sumatriptan (as succinate) 4mg/0.5mL, 6mg/0.5mL; for SC inj.

Company:
GlaxoSmithKline

Therapeutic Use:

Indications for IMITREX INJECTION:

Acute treatment of migraine or cluster headaches.

Adult:

≥18yrs: 6mg SC (may start at lower dose if 6mg not tolerated). Reevaluate if no response. May repeat after 1 hour; max two 6mg doses in 24 hours.

Children:

<18yrs: not recommended.

Contraindications:

Do not give intravenously. History, symptoms, or signs of ischemic cardiac (eg, MI, angina pectoris, silent myocardial ischemia), cerebrovascular (eg, stroke, TIA), or peripheral vascular (eg, ischemic bowel disease) syndromes. Vasospastic coronary artery disease. Uncontrolled hypertension. Basilar or hemiplegic migraine. Severe hepatic impairment. Within 24 hours of ergot-type drugs (eg, methysergide, dihydroergotamine), or other 5-HT1 agonists. During or within 2 weeks after discontinuing MAO-A inhibitors (MAOI type A).

Warnings/Precautions:

Confirm diagnosis. Avoid excessive use. Exclude underlying cardiovascular disease, supervise 1st dose, and consider monitoring ECG in patients with likelihood of unrecognized coronary artery disease (eg, postmenopausal women, hypercholesterolemia, men over age 40, hypertension, obesity, diabetes, smokers, strong family history). Monitor cardiovascular function in long-term intermittent use. Instruct patient on use of autoinjector. Peripheral vascular or colonic ischemia following other 5-HT1 agonists. Hepatic or renal dysfunction. Seizure risk. Elderly: not recommended. Pregnancy (Cat.C). Nursing mothers (avoid nursing for 12 hours after treatment).

Interactions:

Ergotamines, other 5-HT1 agonists, MAOIs: see Contraindications. Serotonin syndrome with SSRIs (eg, citalopram, escitalopram, fluoxetine, fluvoxamine, paroxetine, sertraline) or SNRIs (eg, duloxetine, venlafaxine).

See Also:

IMITREX TABLETS

IMITREX NASAL SPRAY

Pharmacological Class:

Selective 5-HT1B/1D receptor agonist.

Adverse Reactions:

Tingling, hot sensation, flushing; chest/neck/sinus/jaw discomfort; dizziness, muscle pain/weakness, fatigue, drowsiness, anxiety, sweating, local reactions, seizures, colonic ischemia, drug overuse headache (discontinue if occurs); rare: serious cardiac and cerebrovascular events (including fatalities), vision loss. Nasal spray: also dysgeusia.

Note:

Register pregnant patients exposed to sumatriptan by calling (800) 336-2176.

How Supplied:

Inj kit (2 prefilled cartridges + 1 Pen)—1; Refills (2 prefilled cartridges)—1; Single-dose vials (6mg/0.5mL)—5; Tabs—9; Nasal spray (single dose)—6

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