Is there a causal relationship between depressive disorders and late-life neurodegenerative diseases? Or, is their co-occurrence due to confounding or common risk factors, such as aging?
Systolic orthostatic hypotension and variability in visit-to-visit seated systolic blood pressure postural change are associated with greater dementia risk.
MRI-based cerebrovascular reactivity is associated with cognitive function independent of Alzheimer disease pathology.
The FDA has accepted for Priority Review the Biologics License Application for aducanumab (Biogen) for the treatment of Alzheimer disease.
Years of education and the ε4 risk allele at APOE influence β-amyloid pathology in asymptomatic individuals with a parental history of sporadic Alzheimer disease, while only years of education influence β-amyloid pathology in presymptomatic autosomal dominant AD mutation carriers.
Plasma tau phosphorylated at threonine 217 (P-tau217) shows promise as a biomarker for Alzheimer disease.
Older adults with both hearing and visual impairments — dual sensory impairment — are at a significantly increased risk for dementia.
At AAIC 2020, 2 presentations separately discussed observing a reduced risk of AD in patients who received the influenza and pneumonia vaccines.
Researchers conducted a randomized clinical trial to assess whether 24 weeks of treatment with rotigotine can modify cognitive functions in patients with mild to moderate Alzheimer disease.
Older adults who have surgery with general anesthesia may experience a modest cortical thinning in the brain, but it does not appear to be tied to Alzheimer disease.