This study examines whether the genetic variation near the apolipoprotein E gene (APOE) is associated with risk of Alzheimer disease independently of the ε2/ε3/ε4 genotype.
Researchers found in an observational cohort study that pre-existing Alzheimer disease and dementia are top risk factors for severe COVID-19 based on their association with positive tests for the coronavirus in England’s hospitals in spring 2020.
Exposure to air pollution is associated with an increased risk for neurological disorders in older adults.
In patients with dementia, pain is a correlate or prodromal symptom rather than a direct cause of dementia.
To evaluate the period prevalence, demographics, symptoms, management, and survival outcomes of COVID-19 in psychiatric inpatients, data from 344 patients in 5 London mental health NHS Trusts who were ≥65 years of age or had dementia were analyzed.
Rural Medicare beneficiaries with Alzheimer disease and related dementia spend more time in nursing homes, receive less home health care, and have shorter survival than their urban counterparts.
While the most common recent approach in Alzheimer disease drug discovery is to directly target the β-amyloid pathway, the high prevalence of apolipoprotein E ε4 in Alzheimer disease and the ease of identifying ε4 carriers make the APOE genotype and its corresponding protein an appealing therapeutic target to slow Aβ accumulation.
More daytime noise exposure may increase the risk for poorer late-life cognition and risk for dementia.
The comorbidity of depressive disorders and late-life neurodegenerative diseases including Alzheimer disease has been widely reported. This study looks into whether there is a causal relationship existing between both or, if their co-occurrence is due to confounding or common risk factors, such as aging.
Apathy is associated with an increased risk for developing probable dementia for community-dwelling older adults.