Generic Name and Formulations:
Fosinopril sodium, hydrochlorothiazide; 10mg/12.5mg, 20mg/12.5mg; tabs.
Various generic manufacturers
Indications for Fosinopril/Hydrochlorothiazide:
Hypertension. Not for initial therapy.
Give once daily. Usual range: fosinopril: 10–20mg; HCTZ: 12.5–50mg. Severe renal impairment (CrCl<30mL/min): not recommended.
Anuria. Hypersensitivity to ACE inhibitors, sulfonamide-derived drugs.
Discontinue if angioedema, laryngeal edema, jaundice, or markedly elevated liver enzymes occurs. Salt/volume depletion; correct before initiating therapy. Renal or hepatic impairment. CHF. Dialysis (esp. high-flux membrane). Renal artery stenosis. Surgery. Diabetes. Gout. SLE. Monitor WBCs in renal or collagen vascular disease. Monitor electrolytes, BUN (if high). Pregnancy (Cat.C in 1st trimester; Cat.D in 2nd and 3rd trimester). Nursing mothers: not recommended.
Potassium or K+-sparing diuretics may cause hyperkalemia. May increase lithium levels. Antagonized by NSAIDs. Separate antacid dosing by 2hrs. May cause false low serum digoxin measurements. May antagonize norepinephrine, methenamine. May potentiate nondepolarizing muscle relaxants. Adjust antidiabetic, antigout medications. ACTH, corticosteroids increase hypokalemia risk. May interfere with parathyroid tests. Nitritoid reactions with injectable gold.
ACE inhibitor + diuretic (thiazide).
Headache, cough, fatigue; hyperkalemia, orthostatic hypotension, angioedema (discontinue if occurs).
Formerly known under the brand name Monopril HCT.
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