Generic Name and Formulations:
Cevimeline HCl 30mg; caps.
Indications for EVOXAC:
Dry mouth associated with Sjogren's syndrome.
30mg three times daily.
Uncontrolled asthma. When miosis is undesirable (eg, acute iritis, narrow-angle glaucoma).
History of cardiovascular disease. Controlled asthma. Chronic bronchitis. COPD. History of nephrolithiasis or cholelithiasis. CYP2D6 deficiency. Pregnancy (Cat.C). Nursing mothers: not recommended.
Potentiated by CYP2D6 and CYP3A3/4 inhibitors. Possible conduction disturbances with β-adrenergic antagonists. Additive effects with parasympathomimetics. May interfere with antimuscarinics.
Excessive sweating (dehydration may develop; drink extra water), rhinitis, excessive salivation, UTI, cough, arthralgia, fatigue, insomnia, hot flushes, GI upset, visual disturbances (eg, blurring, decreased visual acuity), others.
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